scholarly journals Deuterium atom loading of self-damaged tungsten at different sample temperatures

2017 ◽  
Vol 496 ◽  
pp. 1-8 ◽  
Author(s):  
Anže Založnik ◽  
Sabina Markelj ◽  
Thomas Schwarz-Selinger ◽  
Klaus Schmid
Keyword(s):  
Deuterium Atom

scholarly journals Mathematical Modeling of Open States in Double Stranded DNA Molecule Depending on 2H/1H Ratio

2019 ◽  
Vol 14 (2) ◽  
pp. 612-624 ◽  
Author(s):  
S.S. Dzhimak ◽  
M.I. Drobotenko ◽  
A.A. Basov ◽  
A.A. Svidlov ◽  
M.G. Baryshev
Keyword(s):  
Mathematical Modeling ◽  
Hydrogen Bond ◽  
Deuterium Atom ◽  
Living System ◽  
Dna Molecule ◽  
Dna Base Pair ◽  
A Chain ◽  
Time Required ◽  
Open States ◽  
Bond Disruption

The evaluation results of the possible deuterium atoms effect on the DNA base pair opening are presented in the article. The cause of these processes is the replacement of protium with deuterium atom due to the increase of energy required to break the hydrogen bond. These processes can be studied by method of mathematical modeling, with account of open states between base pairs being the key condition of the adequacy of the mathematical model of the DNA. The experiment data show that the presence of deuterium in a chain of nucleotides can cause - depending on the value of hydrogen bond disruption energy - both increase and decrease in probability of open states occurrence. For example: hydrogen bond disruption energy of 0.358·10-22 n·m, non-zero probability of open states occurrence is observed in case of the absence of deuterium in the molecule, and with hydrogen bond disruption energy of 0.359·10-22 n·m or more such probability equals zero. Also, when one deuterium atom is present in a molecule, non-zero probability is observed even with hydrogen bond disruption energy equal to 0.368·10-22 n·m (i.e. more than 0.358·10-22 n·m). Thus participation of deuterium atoms in the formation of hydrogen bonds of double helixes of a DNA molecule can cause the changes in the time required for transfer of genetic information, which can explain the effect of even minor deviations in deuterium concentration in a medium on metabolic processes in a living system.

Silver Salt Enabled H/D Exchange at β Position of Thiophene Rings: Synthesis of Fully Deuterated Thiophene derivatives

2022 ◽  
Author(s):  
Fei-fei Sheng ◽  
En-Ci Li ◽  
Jing-Wen Bai ◽  
Cai-Xia Wang ◽  
Guang-Qi Hu ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
Silver Salt ◽  
Deuterium Atom ◽  
Thiophene Derivatives

We disclose a silver catalyzed H/D exchange reaction, which can introduce deuterium atom at β position of thiophene rings without the assisstance of any coordinating groups. The advantages of this...

scholarly journals Inequality in the Frequency of the Open States Occurrence Depends on Single 2H/1H Replacement in DNA

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3753 ◽  
Author(s):  
Alexander Basov ◽  
Mikhail Drobotenko ◽  
Alexandr Svidlov ◽  
Eugeny Gerasimenko ◽  
Vadim Malyshko ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
False Negative ◽  
Deuterium Atom ◽  
Base Pairs ◽  
Gene Encoding ◽  
Negative Results ◽  
False Negative Results ◽  
Nitrogenous Base ◽  
Open States ◽  
Different Parts

In the present study, the effect of 2H/1H isotopic exchange in hydrogen bonds between nitrogenous base pairs on occurrence and open states zones dynamics is investigated. These processes are studied using mathematical modeling, taking into account the number of open states between base pairs. The calculations of the probability of occurrence of open states in different parts of the gene were done depending on the localization of the deuterium atom. The mathematical modeling study demonstrated significant inequality (dependent on single 2H/1H replacement in DNA) among three parts of the gene similar in length of the frequency of occurrence of the open states. In this paper, the new convenient approach of the analysis of the abnormal frequency of open states in different parts of the gene encoding interferon alpha 17 was presented, which took into account both rising and decreasing of them that allowed to make a prediction of the functional instability of the specific DNA regions. One advantage of the new algorithm is diminishing the number of both false positive and false negative results in data filtered by this approach compared to the pure fractile methods, such as deciles or quartiles.

scholarly journals Some Decomposition Routes in the Mass Spectra of Aromatic Carboxylic Acids

1965 ◽  
Vol 20 (7) ◽  
pp. 883-887 ◽  
Author(s):  
J. H. Beynon ◽  
B. E. Job ◽  
A. E. Williams
Keyword(s):  
Carboxylic Acid ◽  
Benzoic Acid ◽  
Terephthalic Acid ◽  
Phthalic Acid ◽  
Mass Spectra ◽  
Deuterium Atom ◽  
Acid Group ◽  
Isophthalic Acid ◽  
Carboxylic Acid Group ◽  
Hydrogen Atoms

The mass spectra of benzoic acid, phthalic acid, isophthalic acid and terephthalic acid, together with the analogues deuterated on the carboxylic acid group have been studied. Exchange of the deuterium atom with hydrogen atoms on the positions ortho to a carboxylic acid group on the aromatic ring has been studied using meta-stable peaks.

Isotopic Exchange Between Hydrogen and Water Vapor over Supported Metal Catalysts. Part I. Kinetics of the Exchange

1972 ◽  
Vol 50 (12) ◽  
pp. 1900-1906 ◽  
Author(s):  
J. H. Rolston ◽  
J. W. Goodale
Keyword(s):  
Water Vapor ◽  
Transfer Rate ◽  
Water Vapor Pressure ◽  
Adsorbed Water ◽  
Deuterium Atom ◽  
Supported Metal Catalysts ◽  
Vapor Pressures ◽  
Order Dependence ◽  
Rate Limiting ◽  
Kinetics Of

Some rate data for the transfer of a deuterium atom tracer between hydrogen and water vapor, catalyzed by platinum supported on γ-alumina, are reported. Above 100 °C the transfer rate measured at 1 atm total pressure is shown to be free of mass transfer effects, and obeys an initial first order dependence on water vapor for vapor pressures less than 10 Torr. A near zero order dependence is observed at higher water vapor pressures. At temperatures below 100 °C the transfer rate is essentially independent of water vapor pressure between 5 and 100 Torr suggesting that surface adsorbed water is involved in the rate limiting transfer step.

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