The role of oxidative stress on degeneration of rotator cuff enthesis-An analysis of the effect of an anti-oxidant treatment

Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the production and accumulation of ROS, thus protecting cells from oxidative damage. Since sestrin2 is reported to have anti-oxidant and anti-inflammatory properties, it may play a protective role against the progression of atherosclerosis and may be a potential therapeutic target for the amelioration of atherosclerosis. Regarding the association between blood sestrin2 levels and atherosclerotic disease, the blood sestrin2 levels in patients with CAD or carotid atherosclerosis were reported to be high. High blood sestrin2 levels in patients with such atherosclerotic disease may reflect a compensatory response to increased oxidative stress and may help protect against the progression of atherosclerosis. This review describes the protective role of sestrin2 against the progression of atherosclerotic and cardiac diseases.

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Curcumin and Endometriosis

International Journal of Molecular Sciences ◽

10.3390/ijms21072440 ◽

2020 ◽

Vol 21 (7) ◽

pp. 2440 ◽

Cited By ~ 1

Author(s):

Alexandre Vallée ◽

Yves Lecarpentier

Keyword(s):

Oxidative Stress ◽

Inflammatory Responses ◽

Uterine Cavity ◽

Main Role ◽

Oxygen Species ◽

Inflammatory Agent ◽

Gynecological Disorders ◽

Anti Oxidant ◽

Anti Inflammatory

Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

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Role of Anti-oxidants in the Treatment of Vitiligo

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v17i1.23132 ◽

2019 ◽

Vol 17 (1) ◽

pp. 49-57

Author(s):

Amit Kumar ◽

Sudha Agrawal ◽

Tapan Kumar Dhali ◽

Shankar Kumr Majhi

Keyword(s):

Oxidative Stress ◽

Placebo Group ◽

Vitamin E ◽

Primary Outcome ◽

Antioxidant Supplementation ◽

Significant Difference ◽

Anti Oxidant ◽

And Oxidative Stress

Introduction: The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies. Antioxidant supplementation has been reported to be useful in the treatment of vitiligo. Objective: To evaluate the role of oral antioxidants supplementation therapy in the treatment of vitiligo by assessing the onset of repigmentation and oxidative stress. Materials and Methods: A total of 80 cases of vitiligo randomized into two groups: antioxidant and placebo comprising 40 patients each and were followed up for 8 weeks for the assessment of onset of repigmentation of vitiliginous lesions as primary outcome. The activities of Malondialdehyde (MDA), Vitamin C, and Vitamin E in serum and of Catalase (CAT) in erythrocytes of patients at baseline and at end of eight weeks were also assessed by using the spectrophotometric assay. Results: The onset of repigmentation was noted significantly earlier among the anti-oxidant group as compared to the placebo group (p=0.015). At the baseline, between the two groups, no significant difference was found in the different biochemical parameters. However, at the end of 2 months the level of MDA (p<0.001) was found to be significantly lower and that of Vitamin E (p<0.001) and CAT (p=0.005) was significantly higher among the anti-oxidants group as compared to the placebo group. Conclusion: Antioxidant supplementation carried a better response in terms of early onset of repigmentation and significant decrease in the oxidative stress, in the short follow up of two months.

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The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum-Induced Peripheral Neurotoxicity

Current Cancer Drug Targets ◽

10.2174/156800910793605820 ◽

2010 ◽

Vol 10 (7) ◽

pp. 670-682 ◽

Cited By ~ 44

Author(s):

V. A. Carozzi ◽

P. Marmiroli ◽

G. Cavaletti

Keyword(s):

Oxidative Stress ◽

Peripheral Neurotoxicity ◽

Anti Oxidant

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Free fatty acid induce oxidative stress in HEPG2-cell. Protective role of anti-oxidant substances and adiponectin

Digestive and Liver Disease ◽

10.1016/j.dld.2007.12.094 ◽

2008 ◽

Vol 40 (5) ◽

pp. A37-A38

Author(s):

G. Soardo ◽

D. Donnini ◽

C. Pagano ◽

C. Milocco ◽

L. Domenis ◽

...

Keyword(s):

Oxidative Stress ◽

Fatty Acid ◽

Free Fatty Acid ◽

Hepg2 Cell ◽

Protective Role ◽

Anti Oxidant

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The role of oxidative stress on degeneration of rotator cuff enthesis

Journal of Shoulder and Elbow Surgery ◽

10.1016/j.jse.2012.10.004 ◽

2012 ◽

Vol 21 (12) ◽

pp. e25

Author(s):

Daichi Morikawa ◽

Yoshiaki Itoigawa ◽

Hidetoshi Nojiri ◽

Hirotaka Sano ◽

Eiji Itoi ◽

...

Keyword(s):

Oxidative Stress ◽

Rotator Cuff

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Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y00-120 ◽

2001 ◽

Vol 79 (3) ◽

pp. 266-282 ◽

Cited By ~ 28

Author(s):

Bernhard HJ Juurlink

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Therapeutic Effects ◽

Phase 2 ◽

Phase 2 Enzymes ◽

Anti Oxidant ◽

Inflammatory Component ◽

Enzyme Inducers

Many diseases associated with ageing have an underlying oxidative stress and accompanying inflammatory component, for example, Alzheimer's disease or atherosclerosis. Reviewed in this manuscript are: the role of oxidative stress in activating the transcription factor nuclear factor kappa B (NFκB), the role of NFκB in activating pro-inflammatory gene transcription, strong oxidants produced by cells, anti-oxidant defense systems, the central role of phase 2 enzymes in the anti-oxidant defense, dietary phase 2 enzyme inducers and evidence that dietary phase 2 enzymes decrease oxidative stress. It is likely that a diet containing phase 2 enzyme inducers may ameliorate or even prevent diseases that have a prominent inflammatory component to them. Research should be directed into the potential therapeutic effects of dietary phase 2 enzyme inducers in ameliorating diseases with an underlying oxidative stress and inflammatory component to them.Key words: Alzheimer's disease, atherosclerosis, diet, glutathione, inflammation, stroke.

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Role of oxidative stress and antioxidant supplementation in Male fertility

Current Molecular Medicine ◽

10.2174/1566524020999200831123553 ◽

2020 ◽

Vol 20 ◽

Cited By ~ 1

Author(s):

Zahra Beygi ◽

Sedighe Forouhari ◽

Elahe Mahmoudi ◽

Seyed Mohammad Gheibi Hayat ◽

Firoozeh Nourimand

Keyword(s):

Oxidative Stress ◽

Life Style ◽

Male Fertility ◽

Treatment Strategies ◽

Infertile Male ◽

Dna Damages ◽

Vitamins E And C ◽

Anti Oxidant ◽

Universal Health

: Nearly 15% of couples involve in infertility as a universal health issue. About 50% of infertility cases have been known to be associated with the male parameters. Oxidative stress (OS) represents an imbalance in the level of reactive ox-ygen species (ROS) and anti-oxidant. In fact, OS has been considered as one of the popular pathologies reported in about 50% of all infertile male. Therefore, the increased level of ROS may result in infertility via DNA damages or lipid peroxida-tion (LPO) as well as the enzymes inactivation and proteins oxidation in spermatozoa. Basically, OS results from the life-style variables. As the absence of antioxidant and the respective deficiencies in the semen cause OS, variations in the life-style and anti-oxidant regimes may be advantageous to treatment strategies for resolving such an issue. Actually, anti-oxidants like vitamins E and C, glutathione, coenzyme-Q10, carnitines, selenium, N-acetylcysteine, carotenoids, zinc, and pentoxifylline decline the OS-induced sperm damages.Therefore, the present review overviews the oxidative bio-chemistry associated with the sperm health and identifies which men would be most at risk of the oxidative infertility. Hence, the re-view would show the techniques provided to diagnose OS and diverse therapeutic options.

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OXIDATIVE STRESS MODULATES HEME LEVELS and INDUCES PEROXIREDOXIN-2 IN β THALASSEMIC ERYTHROPOIESIS as NOVEL CYTOPROTECTIVE RESPONSE

Blood ◽

10.1182/blood.v116.21.4266.4266 ◽

2010 ◽

Vol 116 (21) ◽

pp. 4266-4266

Author(s):

Lucia De Franceschi ◽

Mariarita Bertoldi ◽

Maria Domenica Cappellini ◽

Luigia De Falco ◽

Sara Santos Franco ◽

...

Keyword(s):

Oxidative Stress ◽

Conflicts Of Interest ◽

Late Phase ◽

Erythroid Cell ◽

Beta Thalassemia ◽

Heme Oxygenase 1 ◽

Heme Binding ◽

Peroxiredoxin 2 ◽

Anti Oxidant

Abstract Abstract 4266 Beta thalassemia (β-thal) syndromes are worldwide distributed congenital red cell disorders. Increased levels of reactive-oxygen-species (ROS) have been reported to contribute to anemia in β-thal but the mechanism(s) involved in cell protection against ROS damage has only partially investigated. Here, we studied in vitro normal and β-thal erythropoiesis in erythroid cell cultures from CD34+ cells isolated from peripheral blood from adult normal volunteers and from homozygous (bcod39) b-thalassemia patients. We showed increased ROS production in β-thal erythropoiesis and we evaluated the effects of ROS on normal and β-thal erythropoiesis. We carried out a proteomic comparative study, validated by coupling Quantitative-Real time PCR and immunoblot analysis of the differently expressed proteins. We found down-regulation in expression of enzymes involved in heme catabolism such as biliverdin reductase (BVR) and heme-oxygenase-1 (HO-1) and up-regulation of two new cytoprotective cysteine-based-systems: peroxiredoxin-2 (Prx2) and heat-shock-protein-27 (HSP27), while catalase was similarly expressed in both cell models, suggesting a specific pattern of Px2 and HSP27 in β-thal erythroid precursors. We then measured heme levels and during b-thal-erythropoiesis and found that the synthesis of heme was biphasic displaying an increase of heme levels in early phase followed by a decrease in late phase in comparison to controls. Since heme synthesis depends on the erythroid δ-aminolevulinate-synthase isoform (ALAS-2), we evaluated ALAS-2 expression that resulted similar in normal and β-thal erythroid cells. We then showed that ALAS-2 activity was inhibited by both ROS and hemin, suggesting a possible role of heme and ROS levels in regulation of heme biosynthesis in β-thal cells. Since it has been reported that oxidative stress can up-regulate Prx2 expression and that genetically modified cells over-expressing Prx2 are generally more protected from severe oxidative stress (Phalen TJ et al 2006; Rabilloud T et al 2002; Kang SW et al 1998; Zhang P et al 1997), we have hypothesized a cytoprotective role of Prx2 in b-thal-erythropoiesis. We determined that the anti-oxidant Prx2 specifically binds hemin with high and affinity, most likely involving Prx2 cysteine residues. In order to look for the structural determinants to the binding, we noted that both ALAS-2 and Prx2 possess one and two cys-pro motifs, respectively. This motif is generally considered a heme sensor for many proteins able to bind heme and we propose that it could be responsible for heme binding in both enzymes. These data suggest a wider role of Prx2 as both anti-oxidant and heme-binding protein in protective stress-response-systems in β-thal erythropoiesis. Disclosures: No relevant conflicts of interest to declare.

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