Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats

2014 ◽  
Vol 23 (6) ◽  
pp. 1429-1439 ◽  
Author(s):  
Ken Uekawa ◽  
Yu Hasegawa ◽  
Mingjie Ma ◽  
Takashi Nakagawa ◽  
Tetsuji Katayama ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Nuclear Factor Kappa B ◽  
Early Brain Injury ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Superoxide Formation

scholarly journals Progesterone Prevents Traumatic Brain Injury-Induced Intestinal Nuclear Factor kappa B Activation and Proinflammatory Cytokines Expression in Male Rats

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Gang Chen ◽  
Jinxin Shi ◽  
Yasuo Ding ◽  
Hongxia Yin ◽  
Chunhua Hang
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Proinflammatory Cytokines ◽  
Nuclear Factor Kappa B ◽  
Mucosal Injury ◽  
Therapeutic Benefit ◽  
Binding Activity ◽  
Male Rats ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

We have previously shown that traumatic brain injury (TBI) can induce an upregulation of nuclear factor kappa B (NF-κB) and proinflammatory cytokines in the gut, which play an important role in the pathogenesis of acute gut mucosal injury mediated by inflammation. In this work, we investigated whether progesterone administration modulated intestinal NF-κB activity and proinflammatory cytokines expression after TBI in male rats. As a result, we found that administration of progesterone following TBI could decrease NF-κB binding activity, NF-κB p65 protein expression, and concentrations of interleukin-1β(IL-1β), and tumor necrosis factor-α(TNF-α) in the gut. TBI-induced damages of gut structure were ameliorated after progesterone injections. The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-κB activation and proinflammatory cytokines expression.

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