The Relationship between Functional Outcome and Prehospital Time Interval in Patients with Cerebral Infarction

2017 ◽  
Vol 26 (12) ◽  
pp. 2800-2805 ◽  
Author(s):  
Soichiro Seno ◽  
Satoshi Tomura ◽  
Kenichiro Ono ◽  
Shinji Akitomi ◽  
Yasumasa Sekine ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Functional Outcome ◽  
Time Interval ◽  
Prehospital Time ◽  
The Relationship

scholarly journals Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Shuhong Yu ◽  
Yi Luo ◽  
Tan Zhang ◽  
Chenrong Huang ◽  
Yu Fu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Outcome ◽  
Odds Ratio ◽  
Poor Outcome ◽  
Net Reclassification Improvement ◽  
Potential Biomarker ◽  
The Impact ◽  
The Relationship ◽  
Integrated Discrimination Improvement

Abstract Background It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS patients remains unclear. We aimed to determine the relationship between EMR on admission and 3-month poor functional outcome in AIS patients. Methods A total of 521 consecutive patients admitted to our hospital within 24 h after onset of AIS were prospectively enrolled and categorized in terms of quartiles of EMR on admission between August 2016 and September 2018. The endpoint was the poor outcome defined as modified Rankin Scale score of 3 to 6 at month 3 after admission. Results As EMR decreased, the risk of poor outcome increased (p < 0.001). Logistic regression analysis revealed that EMR was independently associated with poor outcome after adjusting potential confounders (odds ratio, 0.09; 95% CI 0.03–0.34; p = 0.0003), which is consistent with the result of EMR (quartile) as a categorical variable (odds ratio, 0.23; 95% CI 0.10–0.52; ptrend < 0.0001). A non-linear relationship was detected between EMR and poor outcome, whose point was 0.28. Subgroup analyses further confirmed these associations. The addition of EMR to conventional risk factors improved the predictive power for poor outcome (net reclassification improvement: 2.61%, p = 0.382; integrated discrimination improvement: 2.41%, p < 0.001). Conclusions EMR on admission was independently correlated with poor outcome in AIS patients, suggesting that EMR may be a potential prognostic biomarker for AIS.

scholarly journals Impact of diet on the immunological microenvironment of the pregnant uterus and its relationship to allergic disease in the offspring: a review of the recent literature

2006 ◽  
Vol 124 (5) ◽  
pp. 298-303 ◽  
Author(s):  
Daniella Campelo Batalha Cox Moore ◽  
Pedro Xavier Elsas ◽  
Elisabeth Santos Maximiano ◽  
Maria Ignez Capella Gaspar Elsas
Keyword(s):  
Allergic Disease ◽  
Allergic Diseases ◽  
Perinatal Period ◽  
Time Interval ◽  
Industrialized Countries ◽  
Pregnant Uterus ◽  
Medical Progress ◽  
Immunological Profile ◽  
Dietary Content ◽  
The Relationship

Medical progress has reduced the mortality from infectious diseases in most countries, but allergic diseases have become more prevalent worldwide over the same period, especially in industrialized countries. This has prompted speculation that modern lifestyles have altered the relationship between heredity and environment so as to promote development of an atopic phenotype when exposure to infection decreases. A healthy uterine microenvironment is known to favor Th2 lymphocyte development. However, some evidence suggests that persistence of the Th2 pattern of immunity directs the developing organism's immune response towards a long-lasting atopic phenotype. Even though the outcome also depends on other factors (such as infection, functional state of the intestinal microflora, and exposure to environmental allergens at times critical to development), it seems that the immune system during the perinatal period is responsive to interventions that are no longer effective in adulthood. We have reviewed the literature accessible through Medline to identify recent advances in the prevention of allergic disease through interventions in the fetal-maternal relationship. Diet seems to have a significant impact on the immunological profile of the pregnant uterus, as well as on the postnatal development of allergic disease in the offspring, as suggested by the effects of probiotic bacteria and by manipulations of the dietary content of polyunsaturated fatty acids and antioxidants. This highlights the need for further studies, in order to define the best intervention methods, the most appropriate time interval and the individuals who will most likely benefit from them.

scholarly journals Impact of infarct location on functional outcome following endovascular therapy for stroke

2018 ◽  
Vol 90 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Charlotte Rosso ◽  
Raphael Blanc ◽  
Julien Ly ◽  
Yves Samson ◽  
Stéphane Lehéricy ◽  
...  
Keyword(s):  
Decision Making ◽  
Functional Outcome ◽  
Internal Capsule ◽  
Brain Regions ◽  
Stepwise Logistic Regression ◽  
Independent Variables ◽  
Good Outcome ◽  
Registration Number ◽  
Independent Variable ◽  
The Relationship

ObjectivesThe relationship between stroke topography (ie, the regions damaged by the infarct) and functional outcome can aid clinicians in their decision-making at the acute and later stages. However, the side (left or right) of the stroke may also influence the identification of clinically relevant regions. We sought to determine which brain regions are associated with good functional outcome at 3 months in patients with left-sided and right-sided stroke treated by endovascular treatment using the diffusion-weighted imaging-Alberta Stroke Program Early CT Score (DWI-ASPECTS).MethodsPatients with ischaemic stroke (n = 405) were included from the ASTER trial and Pitié-Salpêtrière registry. Blinded readers rated ASPECTS on day 1 DWI. Stepwise logistic regression analyses were performed to identify the regions related to 3-month outcome in left (n = 190) and right (n = 215) sided strokes with the modified Rankin scale (0–2) as a binary independent variable and with the 10 regions-of-interest of the DWI-ASPECTS as independent variables.ResultsMedian National Institute of Health Stroke Scale (NIHSS) at baseline was 17 (IQR: 12–20), median age was 70 years (IQR: 58–80) and median day-one NIHSS 9 (IQR: 4–18). Not all brain regions have the same weight in predicting good outcome at 3 months; moreover, these regions depend on the affected hemisphere. In left-sided strokes, the multivariate analysis revealed that preservation of the caudate nucleus, the internal capsule and the cortical M5 region were independent predictors of good outcome. In right-sided strokes, the cortical M3 and M6 regions were found to be clinically relevant.ConclusionCortical non-motors areas related to outcome differed between left-sided and right-sided strokes. This difference might reflect the specialisation of the dominant and non-dominant hemispheres for language and attention, respectively. These results may influence decision-making at the acute and later stages.Trial registration numberNCT02523261.

scholarly journals Hubungan Perilaku Perdagangan Investor Dengan Volume Perdagangan Di Bursa Efek Indonesia

2009 ◽  
Vol 2 (1) ◽  
Author(s):  
Ghazali Syamni
Keyword(s):  
Trading Volume ◽  
Stock Exchange ◽  
Time Interval ◽  
Time Intervals ◽  
Using Data ◽  
Changes Over Time ◽  
Relationship Of ◽  
The Relationship ◽  
Order Pattern ◽  
Over Time

This paper examines the relationship of behavior trading investor using data detailed transaction history-corporate edition demand and order history in Indonesia Stock Exchange during period of March, April and May 2005. Peculiarly, behavior placing of investor order at trading volume. The result of this paper indicates that trading volume order pattern to have pattern U shape. The pattern happened that investors have strong desires to places order at the opening and close of compared to in trading periods. While the largest orders are of market at the opening indicates that investor is more conservatively when opening, where many orders when opening has not happened transaction to match. In placing order both of investor does similar strategy. By definition, informed investors’ orders more large than uninformed investors. If comparison of order examined hence both investors behavior relatively changes over time. But, statistically shows there is not ratio significant. This implies behavior trading of informed investors and uninformed investors stable relative over time. The result from regression analysis indicates that informed investors to correlate at trading volume in all time intervals, but not all uninformed investors correlates in every time interval. This imply investor order inform is more can explain trading volume pattern compared to uninformed investor order in Indonesia Stock Exchange. Finally, result of regression also finds that order status match has greater role determines trading volume pattern intraday especially informed buy match and informed sale match. While amend, open and withdraw unable to have role to determine intraday trading volume pattern.

scholarly journals Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations

2021 ◽  
Vol 11 ◽  
pp. 204512532110371
Author(s):  
Amir Krivoy ◽  
Eromona Whiskey ◽  
Henrietta Webb-Wilson ◽  
Dan Joyce ◽  
Derek K. Tracy ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Clinical Symptom ◽  
Clinical Improvement ◽  
Clinical Symptoms ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Symptom Improvement ◽  
Blood Concentrations ◽  
Treatment Refractory ◽  
The Relationship

Background: Clozapine is the only medication licenced for treating patients with treatment-refractory schizophrenia. However, there are no evidence-based guidelines as to the optimal plasma level of clozapine to aim for, and their association with clinical and functional outcome. Objective: We assessed the relationship between clinical and functional outcome measures and blood concentrations of clozapine among patients with treatment-refractory psychosis. Methods: Data were reviewed in 82 patients with treatment-refractory psychosis admitted to a specialised tertiary-level service and treated with clozapine. Analysis focussed on the relationship between clozapine and norclozapine plasma concentrations and the patient’s clinical symptoms and functional status. Results: Clinical symptom improvement was positively correlated with norclozapine plasma concentrations and inversely correlated with clozapine to norclozapine plasma concentrations ratio. Clozapine concentrations showed a bimodal association with clinical improvement (peaks around 350 and 660 ng/ml). Clinical symptom improvement correlated with functional outcomes, although there was no significant correlation between the latter and clozapine or norclozapine plasma concentrations. Conclusion: Clozapine treatment was associated with optimal clinical improvement at two different peak plasma concentrations around 350 and 650 ng/ml. Clinical improvement was associated with functional outcome; however, functionality was not directly associated with clozapine concentrations. A subset of patients may require higher clozapine plasma concentrations to achieve clinical improvement.

Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction

2012 ◽  
Vol 224 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Jinkwon Kim ◽  
Dong Hyun Lee ◽  
Myoung-Jin Cha ◽  
Tae-Jin Song ◽  
Ji Hye Park ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Functional Outcome ◽  
Independent Predictor ◽  
Ankle Brachial Index ◽  
Acute Cerebral Infarction ◽  
Poor Functional Outcome

Abstract W P225: The Relationship between Leukocytosis and Time to Neurodeterioration

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Amelia K Boehme ◽  
James E Siegler ◽  
Karen C Albright ◽  
Alexander J George ◽  
Dominique Monlezun ◽  
...  
Keyword(s):  
Functional Outcome ◽  
Functional Outcomes ◽  
Stroke Severity ◽  
Modified Rankin Scale ◽  
Poor Functional Outcome ◽  
Improve Outcome ◽  
Future Studies ◽  
Point Increase ◽  
Stroke Center ◽  
The Relationship

Background: Previous research has illustrated how leukocytosis after acute ischemic stoke (AIS) is related to poor functional outcome. A main predictor of poor functional outcome is neurodeterioration (ND). We sought to explore the relationship between leukocytosis and time to ND to identify a risk factor for a process that predicts poor functional outcome. Methods: Patients admitted to our stroke center (07/08-06/12) were retrospectively assessed. Leukocytosis was defined as WBC >11,000, ND was characterized as ≥ 2 point increase in NIHSS scale and poor functional outcome was classified as modified Rankin Scale (mRS) of 3-6. Patients were grouped into 2 categories: (1) the leukocytosis group- those who developed leukocytosis ≥24 hours after admission and those who presented with leukocytosis and remained at 24 hours and, (2) the non-leukocytosis group- those that did not have leukocytosis and those where the leukocytosis resolved within 24 hours of admission. Results: A cohort of AIS patients (N=476) with median age 64 years, 43% female and 69% Black were assessed. Of the patients with ND (27%), median time to ND was 43 hours. In the leukocytosis group (N=84), 42 (50.6%) of them developed ND. In the non-leukocytosis group (N=312), 75 (24.5%) developed ND. Leukocytosis within 24 hours of admission is predictive of earlier time to ND (p<0.0001; Figure 1). Adjusting for age, stroke severity, glucose, tPA and infection, the leukocytosis group had a 2 times greater risk for developing ND (HR 2.49, 95%CI 1.61-3.84, p<0.0001). Conclusion: Having leukocytosis persist from admission to 24 hours or developing leukocytosis within 24 hours of admission is a significant predictor of early ND, which often results in poor functional outcome. Identifying such a predictor can enable physicians to identify those at risk for ND and subsequent poor functional outcomes. Future studies are needed to identify if interventions targeting leukocytosis may improve outcome after stroke.

A Method for Controlling Arrival Time to Prevent Late Arrival by Manipulating Vehicle Timetable Information

2020 ◽  
Vol 1 (1) ◽  
pp. 1-17
Author(s):  
Kyosuke Futami ◽  
Tsutomu Terada ◽  
Masahiko Tsukamoto
Keyword(s):  
Public Transportation ◽  
Psychological Factors ◽  
Arrival Time ◽  
Time Interval ◽  
Prototype System ◽  
Time Intervals ◽  
Target Vehicle ◽  
Late Arrival ◽  
Departure Time ◽  
The Relationship

Although it is socially and ethically important not to be late for a specified arrival time, late arrivals sometimes happen to people using public transportation. Although many methods aim to smooth a user's movement by providing useful information, there are few approaches to prevent late arrivals due to psychological factors. In this research, to make a user's arrival time earlier and thus prevent late arrival, we propose a method that manipulates time allowance by presenting information based on a psychological and cognitive tendency. We apply this method to a vehicle timetable system for the purpose of preventing public transit users from arriving after a target vehicle's departure time. Our proposed timetable system manipulates the time intervals between a user's target vehicle and other vehicles by introducing fictional elements such as hidden vehicles and inserted fictional vehicles. This method uses the relationship between the time allowance and the departure time interval, and it can make a user desire and accept arriving at a station earlier. We implemented a prototype system and conducted four experiments. The evaluation results confirmed that our proposed method is effective for changing a user's time allowance and actual arrival time.

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