scholarly journals MP66-18 INTAKE OF ROYAL JELLY PREVENTS SUNITINIB-INDUCED APPETITE LOSS IN PATIENTS WITH RENAL CELL CARCINOMA: CORRELATION WITH SERUM LEVELS OF TRANSFORMING GROWTH FACTOR-β AND MACROPHAGE COLONY-STIMULATING FACTOR

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
kojiro ohba ◽  
Yasuyoshi Miyata ◽  
Yuichiro Nakamura ◽  
Kyohei Araki ◽  
Takuji Yasuda ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Royal Jelly ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Serum Levels ◽  
Colony Stimulating Factor ◽  
Appetite Loss ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

scholarly journals Early Cytokine and Chemokine Gene Expression duringPseudomonas aeruginosa Corneal Infection in Mice

1998 ◽  
Vol 66 (1) ◽  
pp. 376-379 ◽  
Author(s):  
Karen A. Kernacki ◽  
Dennis J. Goebel ◽  
Michael S. Poosch ◽  
Linda D. Hazlett
Keyword(s):  
Transforming Growth Factor ◽  
Rnase Protection Assay ◽  
Colony Stimulating Factor ◽  
Necrosis Factor Alpha ◽  
Rnase Protection ◽  
Corneal Infection ◽  
Cytokines And Chemokines ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

ABSTRACT Using a multiprobe RNase protection assay, we examined cytokine and chemokine mRNAs that were expressed after corneal infection withPseudomonas aeruginosa in mice. Cytokines that were upregulated included interleukin-1α (IL-1α) and -1β, IL-1 receptor antagonist, IL-6, IL-11, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, stem cell factor, lymphotoxin β, transforming growth factor β1, and tumor necrosis factor alpha. Chemokine transcripts that were upregulated included Eotaxin; gamma-interferon-inducible protein 10; monocyte chemoattractant protein 1; macrophage inflammatory proteins 1α, 1β, and 2; and RANTES. Peak expression of these cytokines and chemokines was observed between 1 and 3 days after infection. These responses returned to or approached baseline preinfection levels by 7 days after ocular challenge. Identification of the various cytokines and chemokines upregulated during corneal infection provides important information relevant to unraveling the pathogenesis induced by this bacterium and provides hope that specific molecules can be targeted for therapy.

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