scholarly journals PMD25 - RISK FACTORS ASSOCIATED WITH PCO FOLLOWING CATARACT SURGERY: REAL-WORLD OUTCOMES STUDY IN THE UNITED KINGDOM (UK)

2018 ◽  
Vol 21 ◽  
pp. S247
Author(s):  
M. Dhariwal ◽  
D. O'Boyle ◽  
C. Bouchet ◽  
J. Khan ◽  
A. Venerus ◽  
...  
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Cataract Surgery ◽  
Real World ◽  
Factors Associated ◽  
The United Kingdom ◽  
Outcomes Study

scholarly journals Clinical, geographical, and temporal risk factors associated with presentation and outcome of vivax malaria imported into the United Kingdom over 27 years: observational study

BMJ ◽  
2015 ◽  
Vol 350 (apr16 13) ◽  
pp. h1703-h1703 ◽  
Author(s):  
C. Broderick ◽  
B. Nadjm ◽  
V. Smith ◽  
M. Blaze ◽  
A. Checkley ◽  
...  
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Observational Study ◽  
Vivax Malaria ◽  
Factors Associated ◽  
The United Kingdom

scholarly journals Trends in multidrug-resistant tuberculosis in Scotland, 2000-7

2009 ◽  
Vol 14 (11) ◽  
Author(s):  
L F Anderson ◽  
I F Laurenson ◽  
O Blatchford ◽  
E Shakir ◽  
J McMenamin ◽  
...  
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Treatment Outcome ◽  
Multidrug Resistant ◽  
Control Measures ◽  
Self Report ◽  
Factors Associated ◽  
The United Kingdom ◽  
Mdr Tb

Overall numbers of multidrug-resistant (MDR) tuberculosis (TB) rose sharply in the United Kingdom and Scotland in 2007. Risk factors associated with MDR TB in the United Kingdom have been identified but there has been no previous report on risk factors associated with MDR TB in Scotland. Enhanced Surveillance of Mycobacterial Infections (ESMI) data were used to examine demographic and clinical characteristics and treatment outcome of MDR TB cases notified in Scotland between 2000-7. There was a total of 11 culture-positive cases of MDR TB, five of which were notified in 2007. The majority of patients were female, 15-44 years old and unemployed. All were born outside the United Kingdom and most had arrived within the past year from or frequently travelled to their home countries in China, the Indian subcontinent or Africa. Except for one individual, our patients did not self report a history of previous diagnosis of TB which was previously identified as a risk factor for MDR TB in the United Kingdom. Only three patients received directly observed treatment (DOT). Only two patients had completed treatment at 12 months, partially due to the inadequate length of follow-up under the current ESMI system. Our results suggest that most patients had primary resistance due to transmission of MDR TB in high incidence countries and thus point to the importance of international efforts to control MDR TB in these countries. In Scotland, national efforts should be made to increase the number of MDR TB patients receiving DOT and to extend follow-up to improve monitoring of treatment outcome. It is important to identify high risk groups for MDR TB infection in order to deliver effective community-based disease control measures.

scholarly journals Augmented renal clearance: a retrospective, cohort study of urinary creatinine clearance in critically ill patients in the United Kingdom

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110155
Author(s):  
Brian W Johnston ◽  
David Perry ◽  
Martyn Habgood ◽  
Miland Joshi ◽  
Anton Krige
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Creatinine Clearance ◽  
Renal Clearance ◽  
Repeated Measures ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Augmented Renal Clearance ◽  
Urinary Creatinine ◽  
The United Kingdom

Objective Augmented renal clearance (ARC) is associated with sub-therapeutic antibiotic, anti-epileptic, and anticoagulant serum concentrations leading to adverse patient outcomes. We aimed to describe the prevalence and associated risk factors for ARC development in a large, single-centre cohort in the United Kingdom. Methods We conducted a retrospective observational study of critically unwell patients admitted to intensive care between 2014 and 2016. Urinary creatinine clearance was used to determine the ARC prevalence during the first 7 days of admission. Repeated measures logistic regression was used to determine risk factors for ARC development. Results The ARC prevalence was 47.0% (95% confidence interval [95%CI]: 44.3%–49.7%). Age, sex, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and sepsis diagnosis were significantly associated with ARC. ARC was more prevalent in younger vs. older (odds ratio [OR] 0.95 [95%CI: 0.94–0.96]), male vs. female (OR 0.32 [95%CI: 0.26–0.40]) patients with lower vs. higher APACHE II scores (OR 0.94 [95%CI: 0.92–0.96]). Conclusions This patient group probably remains unknown to many clinicians because measuring urinary creatinine clearance is not usually indicated in this group. Clinicians should be aware of the ARC risk in this group and consider measurement of urinary creatinine clearance.

scholarly journals Sacubitril/Valsartan for Heart Failure: Exciting Times but Are Doctors Informed and Ready?

2018 ◽  
Vol 12 ◽  
Author(s):  
Prithwish Banerjee
Keyword(s):  
Heart Failure ◽  
United Kingdom ◽  
Real World ◽  
Technology Appraisal ◽  
The United Kingdom

Sacubitril/Valsartan in now being prescribed by heart failure/cardiology teams across the United Kingdom following the publication of the NICE technology appraisal guidance but is everyone ready for it? This article discusses the practical aspects of what to do and not to do in relation to the drug  based on real world experience from our centre. 

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