scholarly journals PRO1 TREATMENT OPTIONS FOR PATIENTS WITH RETT SYNDROME: A SYSTEMATIC LITERATURE REVIEW

2019 ◽  
Vol 22 ◽  
pp. S335
Author(s):  
O. Dabbous ◽  
J. Chorazy ◽  
K. Borkowska ◽  
V. Georgieva ◽  
V. Taieb ◽  
...  
Keyword(s):  
Literature Review ◽  
Rett Syndrome ◽  
Systematic Literature Review ◽  
Treatment Options

scholarly journals Non-lesional treatment options for tremor in idiopathic Parkinson syndrome: a protocol for a systematic literature review

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e048367
Author(s):  
Anna Julia Pedrosa Carrasco ◽  
Felicitas Mügge ◽  
David José Pedrosa
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Treatment Options ◽  
Inclusion Criteria ◽  
Parkinson Syndrome ◽  
Registration Number ◽  
Future Publication ◽  
Rich Data ◽  
Improve Patient

IntroductionIdiopathic Parkinson syndrome (iPS) is one of the most common neurodegenerative disorders characterised by the triad of bradykinesia, rigidity and tremor. Tremor at rest predominantly at one side is often perceived by patients as severely disabling and yet ranges among the most difficult symptoms to treat. In medically refractory cases, lesional approaches have proven to be effective alternatives. However, to date, there is no comprehensive analysis of non-surgical therapies to manage iPS-patients’ tremor. We therefore present a detailed study protocol for a systematic literature review assessing efficacy/effectiveness and safety of non-lesional treatments for tremor in iPS.Methods and analysisWe will search three electronic databases (MEDLINE, EMBASE and PsycINFO) using a combination of title/abstract keywords. Additionally, hand-searched reference and citation lists of key reviews identified through the search strategy will be screened. Eligible studies should investigate the efficacy/effectiveness and safety of therapeutic options for tremor in iPS excluding lesional interventions. Publications will be independently assessed for inclusion criteria by two investigators and study information summarised using a standardised template including quality assessment according to the QualSyst tool. We will provide a narrative synthesis of results and conduct a meta-analysis whenever possible.Ethics and disseminationWe commit to present contemporary evidence on the efficacy/effectiveness and safety of non-lesional interventions for tremor in iPS in a future publication. We aim to compile rich data of published studies to inform healthcare professionals in order to ultimately improve patient outcomes.PROSPERO registration numberCRD42020202911).

scholarly journals PRO35 ECONOMIC BURDEN OF CARE IMPOSED ON PATIENTS WITH RETT SYNDROME: A SYSTEMATIC LITERATURE REVIEW

2019 ◽  
Vol 22 ◽  
pp. S341
Author(s):  
R. Arjunji ◽  
V. Taieb ◽  
E. Abdennadher ◽  
M. Bouchemi ◽  
K. Borkowska ◽  
...  
Keyword(s):  
Literature Review ◽  
Rett Syndrome ◽  
Systematic Literature Review ◽  
Economic Burden ◽  
Burden Of Care

An Insight into Peri-Implantitis: A Systematic Literature Review

2013 ◽  
Vol 2 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Victoria Wilson
Keyword(s):  
Literature Review ◽  
Periodontal Disease ◽  
Systematic Literature Review ◽  
Oral Hygiene ◽  
English Language ◽  
Treatment Options ◽  
Signs And Symptoms ◽  
Radiographic Findings ◽  
Implant Surgery ◽  
Definition Of

Aim This systematic literature review was performed to establish a definition of peri-implantitis, what makes a patient more susceptible to peri-implantitis, the signs and symptoms of peri-implantitis (including radiographic findings), treatment options for peri-implantitis, and to investigate what constitutes a suitable oral hygiene regime. Method A systematic literature review and analysis of publications included in PubMed (articles published between 1998 and 2003; English language; search terms “peri-implantitis”; “mucositis”; “partially edentulous”; “preventative maintenance”; “peri-implantitis and plaque control”; “tissue augmentation”; “diet maintenance of peri-implantitis”; “oral hygiene instruction for implants”) was performed to identify papers providing information about peri-implantitis. Separately sourced publications with peri-implantitis related titles and abstracts were reviewed and analysed. The set criteria for inclusion were peer-reviewed articles. Of 53 papers identified, 23 were included for systematic review. Results Analysis of the papers revealed that patients with implants are more susceptible to developing peri-implantitis than are patients with natural teeth to developing periodontal disease. This is due to the varied peri-implant tissue that surrounds the implant in comparison with the tissue that surrounds a natural tooth. If active periodontal disease is present, peri-implantitis may also develop; however, other secondary factors may also need to be present for this to occur. Conclusion A comprehensive periodontal examination should be carried out prior to implant surgery. The patient should be informed of the necessity of regular maintenance following implant surgery and the prerequisite of maintaining a comprehensive oral hygiene regime to avoid peri-implantitis.

Comparative efficacy and safety of dabrafenib in combination with trametinib versus competing adjuvant therapies for high-risk melanoma

2019 ◽  
Vol 8 (16) ◽  
pp. 1349-1363 ◽  
Author(s):  
Rohini Sharma ◽  
Roy Koruth ◽  
Steve Kanters ◽  
Eric Druyts ◽  
Ahmad Tarhini
Keyword(s):  
High Risk ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Distant Metastasis ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Comparable Efficacy ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Distant Metastasis Free Survival

Aim To conduct a systematic literature review of high-risk resectable cutaneous melanoma adjuvant therapeutics and compare safety and efficacy. Methods: The systematic literature review included randomized controlled trials investigating: dabrafenib plus trametinib (DAB + TRAM), nivolumab, pembrolizumab, ipilimumab, vemurafenib, chemotherapy and interferons. Outcomes included overall survival (OS), relapse-free survival, distant metastasis-free survival and safety. All outcomes were synthesized using Bayesian network meta-analysis. Results: Across relapse-free survival, distant metastasis-free survival and OS, DAB + TRAM had the lowest estimated hazards of respective events relative to all other treatments (exception relative to nivolumab in OS). Differences were significant relative to placebo, chemotherapy, interferons and ipilimumab. Conclusion: DAB + TRAM has improved efficacy over historical treatment options (ipilimumab, interferons and chemotherapy) and comparable efficacy with other targeted and immune checkpoint inhibitors.

scholarly journals Therapeutic Plasma Exchange in Myasthenia Gravis: A Systematic Literature Review and Meta-Analysis of Comparative Evidence

2021 ◽  
Vol 12 ◽  
Author(s):  
Tina S. Ipe ◽  
Adeola R. Davis ◽  
Jay S. Raval
Keyword(s):  
Literature Review ◽  
Myasthenia Gravis ◽  
Plasma Exchange ◽  
Systematic Literature Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Treatment Options ◽  
Therapeutic Plasma Exchange ◽  
Cochrane Library ◽  
Pubmed Database

Background: Patients with Myasthenia Gravis (MG) can be treated acutely with therapeutic plasma exchange (TPE) or intravenous immune globulin (IVIG). To date, there is no definitive understanding of which of the two treatments is more effective and safer. The purpose of this study was to systematically review the literature on the comparative efficacy and safety of TPE to other available treatments for MG.Methods: A systematic literature search for studies published between 1997 and 2017 was performed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using two database sources, MEDLINE (through the PubMed database) and Cochrane Library.Results: The search strategy resulted in 535 articles whose abstracts were reviewed. Among these, 165 full texts articles were reviewed for eligibility and 101 articles were excluded. Of the 165 articles, 64 articles were included for a systematic literature and 11 articles for a meta-analysis.Conclusions: This systematic literature review and meta-analysis of treatment options showed that there was a higher response rate with TPE than IVIG in acute MG patients and patients undergoing thymectomy. There was no difference in mortality between the two treatment options. Our findings highlight the need for additional randomized clinical trials in these patients with MG.

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