High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia

2013 ◽  
Vol 37 (8) ◽  
pp. 922-927 ◽  
Author(s):  
Qitian Mu ◽  
Yungui Wang ◽  
Bing Chen ◽  
Wenbin Qian ◽  
Haitao Meng ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Poor Prognosis ◽  
Lymphoblastic Leukemia ◽  
High Expression ◽  
Cell Acute Lymphoblastic Leukemia

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations

Blood ◽  
2021 ◽  
Author(s):  
Takahiko Yasuda ◽  
Masashi Sanada ◽  
Masahito Kawazu ◽  
Shinya Kojima ◽  
Shinobu Tsuzuki ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
High Expression ◽  
Sequencing Analysis ◽  
Chromosome 1Q ◽  
Disease Outcomes ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Disease Stratification

The genetic basis of leukemogenesis in adults with B-cell acute lymphoblastic leukemia (B-ALL) is largely unclear and its clinical outcome remains unsatisfactory. This study aimed to advance the understanding of biological characteristics, improve disease stratification, and identify molecular targets of adult B-ALL. Adolescents and young adults (AYA; 15-39 years old, n = 193) and adults (40-64 years old, n = 161) with Philadelphia chromosome-negative B-ALL were included in this study. Integrated transcriptomic and genetic analyses were used to classify the cohort into defined subtypes. Of the 323 cases included in the RNA sequencing analysis, 278 (86.1%) were classified into 18 subtypes. The ZNF384 subtype (22.6%) was the most prevalent, with two novel subtypes (CDX2-high and IDH1/2-mut) identified among cases not assigned to the established subtypes. The CDX2-high subtype (3.4%) was characterized by high expression of CDX2 and recurrent gain of chromosome 1q. The IDH1/2-mut subtype (1.9%) was defined by IDH1 R132C or IDH2 R140Q mutations with specific transcriptional and high-methylation profiles. Both subtypes showed poor prognosis and were considered inferior prognostic factors independent of clinical parameters. Comparison with a previously reported pediatric B-ALL cohort (n = 1003) showed that the frequencies of these subtypes were significantly higher in AYA/adults than in children. We delineated the genetic and transcriptomic landscape of adult B-ALL and identified two novel subtypes that predict poor disease outcomes. Our findings highlight the age-dependent distribution of subtypes, which partially accounts for the prognostic differences between adult and pediatric B-ALL.

scholarly journals RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia

2019 ◽  
Vol 10 (16) ◽  
pp. 3842-3850 ◽  
Author(s):  
Qi Han ◽  
Jinlong Ma ◽  
Yan Gu ◽  
Huihui Song ◽  
Malika Kapadia ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
High Expression ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals High expression of LMO2 predicts a favorable outcome in adult patients with BCR/ABL negative B-cell acute lymphoblastic leukemia

2016 ◽  
Vol 11 (3) ◽  
pp. 1917-1922
Author(s):  
RABAB M. ALY ◽  
MONA M. TAALAB ◽  
EMAN M. ABDSALAM ◽  
OMAR H. ELYAMANY ◽  
OMAR E. HASAN
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Adult Patients ◽  
Favorable Outcome ◽  
High Expression ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

2020 ◽  
Vol 19 ◽  
pp. 153303382092843
Author(s):  
Gerardo Juárez-Avendaño ◽  
Nuria Citlalli Luna-Silva ◽  
Euler Chargoy-Vivaldo ◽  
Laura Alicia Juárez-Martínez ◽  
Mayra Noemí Martínez-Rangel ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Lymphoblastic Leukemia ◽  
Acute Leukemia ◽  
B Cell ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Lymphoblastic Leukemia ◽  
Acute Leukemias ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Acute Myeloid

Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico. Material and Methods: Descriptive, cross-sectional and retrospective study, conducted from 2014 to 2018 in which profiles of molecular and immunophenotypic aberrations were investigated in children and adolescents diagnosed with acute leukemia, by evaluating 28 molecular abnormalities by HemaVision-Q28 multiplex RT-PCR kit and standardized EuroFlow Immunophenotyping of bone marrow cells. Results: We included 218 patients, with 82.5% younger than 14 years and 17.5% adolescents. The median age was 9 years and a main peak of incidence was recorded at age of 4 to 5 years. B-cell acute lymphoblastic leukemia was diagnosed in 70.64% of all cases, acute myeloid leukemia was in 22.48%, T-cell acute lymphoblastic leukemia in 6.42%, and mixed lineage acute leukemia in 0.46% of cases. Overall, chromosomal translocations were positive in 29.82% of cases. While 65.31% of patients with acute myeloid leukemia reported aberrancies, only in 18.83% of B-cell acute lymphoblastic leukemia cases genetic abnormalities were obvious. Surprisingly, most prevalent translocations in B-cell acute lymphoblastic leukemia were t(9;22) in 20.7%, followed by t(4;11) in 17.2% and t(6;11) in 13.8%, whereas patients with acute myeloid leukemia showed t(15;17) in 40.6% and t(8;21) in 21.9%. In contrast, an homogeneous expression of t(3;21) and t(6;11) was recorded for T-cell acute lymphoblastic leukemia and mixed lineage acute leukemia cases, respectively. Except for t(1;19), expressed only by pre-B cells, there was no association of any of the studied translocations with differentiation stages of the B-leukemic developmental pathway. Conclusion: Our findings identify near 50% of patients with acute lymphoblastic leukemia at debut with high-risk translocations and poor prognosis in B-cell acute lymphoblastic leukemia as well as an unexpected increase of acute myeloid leukemia cases in young children, suggesting a molecular shift that support a higher incidence of poor prognosis cases in Oaxaca.

Sign in / Sign up

Export Citation Format

Share Document