On-treatment C-reactive protein and HDL cholesterol levels in patients at intermediate cardiovascular risk: Impact on carotid intima-media thickness

The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients.Methods. Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied. All groups were assessed for atherogenic index of plasma (AIP) and cIMT. Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA).Results. The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative (P<0.001). Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNFαand IL-6 (P<0.01), and lower levels of high density lipoprotein cholesterol (HDL-c) (P=0.02). The cIMT correlated with levels of anti-CCP (r=0.513,P=0.001), CRP (r=0.799,P<0.001), TNFα(r=0.642,P=0.001), and IL-6 (r=0.751,P<0.001). In multiple regression analysis, cIMT was associated with CRP (P<0.001) and anti-CCP levels (P=0.03).Conclusions. Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.

Download Full-text

Chronic Carbon Monoxide Exposure Is Associated with the Increases in Carotid Intima-Media Thickness and C-Reactive Protein Level

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.219.201 ◽

2009 ◽

Vol 219 (3) ◽

pp. 201-206 ◽

Cited By ~ 12

Author(s):

Vedat Davutoglu ◽

Suat Zengin ◽

Ibrahim Sari ◽

Cuma Yildirim ◽

Behcet Al ◽

...

Keyword(s):

Carbon Monoxide ◽

Protein Level ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

C Reactive Protein ◽

Reactive Protein ◽

Media Thickness

Download Full-text

Bilirubin Levels and Their Association with Carotid Intima Media Thickness and High-Sensitivity C-reactive Protein in Patients with Psoriasis Vulgaris

American Journal of Clinical Dermatology ◽

10.1007/s40257-014-0069-5 ◽

2014 ◽

Vol 15 (2) ◽

pp. 137-142 ◽

Cited By ~ 18

Author(s):

Sevket Balta ◽

Ilknur Balta ◽

Dimitri P. Mikhailidis ◽

Cengiz Ozturk ◽

Sait Demirkol ◽

...

Keyword(s):

Psoriasis Vulgaris ◽

High Sensitivity ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

C Reactive Protein ◽

Reactive Protein ◽

Media Thickness

Download Full-text

High-Sensitivity C-Reactive Protein and Carotid Intima Media Thickness as Markers of Subclinical Inflammation and Atherosclerosis in Pediatric Patients with Hypercholesterolemia

Molecules ◽

10.3390/molecules25215118 ◽

2020 ◽

Vol 25 (21) ◽

pp. 5118

Author(s):

Lana Blinc ◽

Matej Mlinaric ◽

Tadej Battelino ◽

Urh Groselj

Keyword(s):

Subclinical Atherosclerosis ◽

Elevated Serum ◽

High Sensitivity ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Low Grade ◽

C Reactive Protein ◽

Atherosclerosis Progression ◽

Reactive Protein ◽

Media Thickness

Hypercholesterolemia is a major cause of atherosclerosis development and premature cardiovascular disease (CVD). It leads to inflammation, which further accelerates atherosclerosis progression. Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated serum LDL-c from birth, due to a disease-causing variant in one of the causative genes (LDLR, APOB, PCSK9). In polygenic hypercholesterolemia (PH), the disease-causing genetic variant is absent; it is likely the cumulative result of multiple single nucleotide polymorphisms in LDL metabolism-related genes and other factors, such as lifestyle and environment. In high risk groups, such as patients with FH, an effective primary prevention of CVD must begin in childhood. High-sensitivity C-reactive protein (hsCRP) and carotid intima media thickness (cIMT) are two potential minimally invasive correlates of inflammation and subclinical atherosclerosis progression. hsCRP and cIMT have been shown to be significantly increased in patients with FH and PH relative to healthy controls, with some studies yielding conflicting results. In this review, we aim to summarize current knowledge and recent findings regarding the applicability of hsCRP and cIMT as markers of low-grade inflammation and subclinical atherosclerosis, focusing especially on children and adolescents with hypercholesterolemia.

Download Full-text