McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis

Life Sciences ◽  
2021 ◽  
Vol 272 ◽  
pp. 119194
Author(s):  
Diva de Aguiar Magalhães ◽  
Jalles Arruda Batista ◽  
Stefany Guimarães Sousa ◽  
Jayro dos Santos Ferreira ◽  
Lauanda da Rocha Rodrigues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Experimental Model ◽  
Muscarinic Agonist ◽  
And Oxidative Stress

Carvedilol Attenuates Inflammatory Biomarkers and Oxidative Stress in a Rat Model of Ulcerative Colitis

2015 ◽  
Vol 76 (4) ◽  
pp. 204-214 ◽  
Author(s):  
Amal J. Fatani ◽  
Khaled A. Al-Hosaini ◽  
Mohammed M. Ahmed ◽  
Hatem M. Abuohashish ◽  
Mihir Y. Parmar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Rat Model ◽  
Inflammatory Biomarkers ◽  
And Oxidative Stress

Anti-Ulcerative Effect of Curcumin-Galactomannoside Complex on Acetic Acid-Induced Experimental Model by Inhibiting Inflammation and Oxidative Stress

Inflammation ◽  
2020 ◽  
Vol 43 (4) ◽  
pp. 1411-1422
Author(s):  
S. Sheethal ◽  
M. Ratheesh ◽  
Svenia P. Jose ◽  
S. Asha ◽  
I. M. Krishnakumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acetic Acid ◽  
Experimental Model ◽  
And Oxidative Stress

scholarly journals Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS

2018 ◽  
Vol 8 ◽  
Author(s):  
Leandro do Nascimento Camargo ◽  
Renato Fraga Righetti ◽  
Luciana Ritha de Cássia Rolim Barbosa Aristóteles ◽  
Tabata Maruyama dos Santos ◽  
Flávia Castro Ribas de Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Model ◽  
And Oxidative Stress

Catalase gene rs1001179 polymorphism and oxidative stress in patients with chronic hepatitis C and ulcerative colitis

2015 ◽  
Vol 87 (2) ◽  
pp. 49 ◽  
Author(s):  
I. A. Bulatova ◽  
Yu. I. Tretyakova ◽  
V. V. Shchekotov ◽  
A. P. Shchekotova ◽  
P. V. Ulitina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Catalase Gene ◽  
And Oxidative Stress

scholarly journals Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
N. F. Renna ◽  
C. Lembo ◽  
E. Diez ◽  
R. M. Miatello
Keyword(s):  
Oxidative Stress ◽  
Experimental Model ◽  
Chronic Treatment ◽  
Vascular Tissue ◽  
Vascular Inflammation ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Creation ◽  
And Oxidative Stress

(1) This study aims to demonstrate the causal involvement of renin angiotensin system (RAS) and oxidative stress (OS) on vascular inflammation in an experimental model of metabolic syndrome (MS) achieved by fructose administration to spontaneously hypertensive rats (FFHR) during 12 weeks. (2) Chronic treatment with candesartan (C) (10 mg/kg per day for the last 6 weeks) or 4OH-Tempol (T) (10−3 mmol/L in drinking water for the last 6 weeks) reversed the increment in metabolic variables and systolic blood pressure. In addition, chronic C treatment reverted cardiovascular remodeling but not T. (3) Furthermore, chronic treatment with C was able to completely reverse the expression of NF-κB and VCAM-1, but T only reduced the expression. C reduced the expression of proatherogenic cytokines as CINC2, CINC3, VEGF, Leptin, TNF-alpha, and MCP-1 and also significantly reduced MIP-3, beta-NGF, and INF-gamma in vascular tissue in this experimental model. T was not able to substantially modify the expression of these cytokines. (4) The data suggest the involvement of RAS in the expression of inflammatory proteins at different vascular levels, allowing the creation of a microenvironment suitable for the creation, perpetuation, growth, and destabilization of vascular injury.

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