Comparative therapeutic efficacy of procaine penicillin, Phyllanthus emblica fruit extract and Cocos nucifera oil against subclinical mastitis

The article presents the results of our own research on the therapeutic effectiveness of the use of FORTICEPT UDDER FORTE for post-milk treatment of cows with subclinical mastitis.As is known, one of the reasons for the emergence of mastitis of cows is the lack of proper sanitary-hygienic treatment of breast milk after milking. Taking into consideration the fact after milking, according to various authors, remains open for 30 minutes to 2 hours, it leads to the infection of the mammary gland with the microflora causing its inflammation.The study of the effectiveness of using FORTICEPT UDDER FORTE after milking treatment of cow's doses was performed in comparison with other existing agents: on the basis of chlorhexidine and iodine.The use of FORTICEPT UDDER FORTE for post-milking treatment of cow's dug reduces their incidence by subclinical mastitis by 30–40%.The therapeutic efficacy of using FORTICEPT UDDER FORTE in cows in the first experimental group was 20.1% higher than the other animals (chlorhexidine-based agent) and 13% in the third group (iodine-based).

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Therapeutic efficacy of Enroflon gel in the treatment of clinical and subclinical mastitis in cattle

Agrarian science ◽

10.32634/0869-8155-2020-342-10-18-21 ◽

2020 ◽

pp. 18-21

Author(s):

R. V. Rogov ◽

E. A. Lyusin

Keyword(s):

Therapeutic Effect ◽

Clinical Condition ◽

Therapeutic Efficacy ◽

Hematological Parameters ◽

Animal Health ◽

Live Weight ◽

Subclinical Mastitis ◽

Black And White ◽

Animal Reproduction ◽

White Breed

Relevance. The work is devoted to the study of the therapeutic effect of the drug Enroflon gel on cows of the Holstein black-and-white breed during the period of intensive lactation. Due to the fact that drugs for intracisternal administration based on enrofloxacin and ketoprofen were not used at domestic livestock enterprises, the goal was to study the therapeutic efficacy of the drug in the treatment of clinical and subclinical mastitis of bacterial etiology.Methods. The production experience was carried out in the conditions of the economy of LLC “Babaevo”, with. Babaevo, Sobinsky District, Vladimir Region. Two experimental groups of Holsteinized black-and-white cows with live weight of 500–600 kg with a milk yield of 6000–7000 l/year were formed. When determining the number of somatic cells in milk samples, we used the Kenotest system and the Somatos-V-2K milk analyzer. The presence of a residual amount of antibiotic in milk was determined by inhibitory microbiological tests. Hematological parameters in cows were carried out at the Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction of the Moscow State Academy of Medical Sciences K.I. Scriabin. The drug Enroflon gel was injected intracisternally into the inflamed udder lobe in clinical and subclinical mastitis in cows during lactation. For 15 days, the clinical condition of the cows was monitored. The investigated drug was manufactured at LLC “VIC-Animal Health”.Results. In the treatment of clinical and subclinical mastitis of bacterial etiology in cows during the period of intensive milk production with the use of Enroflon gel, a high therapeutic effect was obtained: 80 and 100%, respectively. The clinical condition of cows during production experiments without deviations from the physiological norm.

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Antimicrobial activity and therapeutic efficacy of thiacycline in subclinical mastitisin sheep

Agrarian science ◽

10.32634/0869-8155-2020-338-5-15-17 ◽

2020 ◽

pp. 5-17

Author(s):

A. Yu. Aliev ◽

B. B. Bulathanov

Keyword(s):

Antimicrobial Activity ◽

Therapeutic Efficacy ◽

Wide Spectrum ◽

Antimicrobial Effect ◽

Subclinical Mastitis ◽

Farm Animals ◽

Control Group ◽

Antibacterial Drug ◽

Combination Drug ◽

Causative Agents

Relevance. The work is devoted to the results of studying of the antimicrobial and therapeutic efficacy of the drug thiacycline in subclinical mastitis in sheep. The aim of our research еsеwas to study the antimicrobial activity and therapeutic efficacy of thiacycline in subclinical mastitis in lactating ewes.Methods. The study of antimicrobial activity was carried out by the method of serial dilutions in a liquid nutrient medium, on the basis of the Caspian zonal NIVI in the laboratory on the study of diseases of non-infectious etiology of farm animals. The therapeutic efficacy of thiacycline was studied in the SEC "Bukhti" of the Gunib district of Dagestan Republic on ewes of the Dagestan rock, aged from 3 to 5 years, with subclinical mastitis, in the amount of 51 heads. Animals on the basis of analogues were divided into two groups: experience (n = 26), control (n = 25). The animals of the experimental group were treated with thiacycline, the drug was administered intramuscularly, once a day, in dose 0.1 ml/kg. The test combination drug thiacycline developed by VIC. The control group was treated with bicillin-3, in dose 600,000 units per head, with an interval 72 hours.Results. The complex antibacterial drug thiacycline has a wide spectrum and high antimicrobial effect against museum strains and potential causative agents of sheep mastitis. The therapeutic efficacy of thiacycline in the treatment of subclinical mastitis in sheep – 97.0%, which is on 13.0% higher compared to bicillin-3. On the 7th day after the last administratin of preparation all the physicochemical parameters of milk corresponded to the physiological norm.

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Therapeutic efficacy of Phyllanthus emblica-coated iron oxide nanoparticles in A549 lung cancer cell line

Nanomedicine ◽

10.2217/nnm-2019-0111 ◽

2019 ◽

Vol 14 (17) ◽

pp. 2355-2371 ◽

Cited By ~ 1

Author(s):

Shivani Thoidingjam ◽

Ashu Bhan Tiku

Keyword(s):

Lung Cancer ◽

Iron Oxide ◽

Cancer Cells ◽

Cell Line ◽

Therapeutic Efficacy ◽

Cancer Cell Line ◽

Lung Cancer Cell Line ◽

Oxide Nanoparticles ◽

Phyllanthus Emblica ◽

Lung Cancer Cell

Aim: Present work was undertaken to fabricate iron oxide nanoparticles (IONPs) using a green approach for increased therapeutic efficacy. Materials & methods: Two types of IONPs were synthesized, one without any coating (IONPUC) and other coated with Phyllanthus emblica (Amla) fruit extract (IONPA). Both the IONPs were characterized using different techniques and therapeutic efficacy was evaluated in A549 human lung cancer cell line. Results: IONPA were smaller in size with better dispersibility compared with IONPUC. They induced increased reactive oxygen species production, higher DNA damage and apoptosis, which resulted in increased toxicity to cancer cells in comparison to IONPUC. Conclusion: Higher uptake of IONPA and active components coating the surface, may be responsible for the increased therapeutic efficacy in cancer cells.

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Potential Protective Effects of Balakka Fruit Extract (Phyllanthus emblica L.) Against Doxorubicin-Induced Pancreatic Toxicity in Rats

Jurnal Aisyah Jurnal Ilmu Kesehatan ◽

10.30604/jika.v5i1.756 ◽

2020 ◽

Vol 5 (1) ◽

pp. 119-127

Author(s):

Viora Rezky Harahap ◽

Refi Ikhtiari ◽

Chrismis Novalinda Ginting ◽

Martinus Ahmad Raif

Keyword(s):

Phyllanthus Emblica ◽

Protective Effects ◽

Fruit Extract ◽

Pancreatic Toxicity

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