Polydopamine/keratin complexes as gatekeepers of mesoporous silica nanoparticles for pH and GSH dual responsive drug delivery

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

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Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

Journal of Materials Chemistry B ◽

10.1039/c7tb02429k ◽

2017 ◽

Vol 5 (48) ◽

pp. 9497-9501 ◽

Cited By ~ 14

Author(s):

Mingyang Hei ◽

Jun Wang ◽

Kelly Wang ◽

Weiping Zhu ◽

Peter X. Ma

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Disulfide Bonds ◽

Mesoporous Silica Nanoparticles ◽

Solution Temperature ◽

Critical Solution Temperature ◽

Dual Responsive ◽

Intracellular Drug Delivery ◽

Upper Critical Solution Temperature

A novel, dual responsive and intracellular delivery system was developed by grafting UCST-type polymers onto the surface of mesoporous silica nanoparticles through disulfide bonds.

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pH and Ultrasound Dual-Responsive Polydopamine-Coated Mesoporous Silica Nanoparticles for Controlled Drug Delivery

Langmuir ◽

10.1021/acs.langmuir.8b01091 ◽

2018 ◽

Vol 34 (34) ◽

pp. 9974-9981 ◽

Cited By ~ 30

Author(s):

Xiaochong Li ◽

Chuan Xie ◽

Hesheng Xia ◽

Zhanhua Wang

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Delivery ◽

Dual Responsive

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A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy

Journal of Materials Chemistry B ◽

10.1039/c8tb00989a ◽

2018 ◽

Vol 6 (28) ◽

pp. 4618-4629 ◽

Cited By ~ 26

Author(s):

Lin Huang ◽

Jia Liu ◽

Fan Gao ◽

Qian Cheng ◽

Bo Lu ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Dual Responsive ◽

Targeted Drug ◽

Hollow Mesoporous Silica ◽

Targeted Drug Delivery System

A novel enzyme and redox dual-responsive targeted drug delivery system based on hollow mesoporous silica nanoparticles was developed for cancer therapy.

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Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190904145355 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1001-1016

Author(s):

Sandra Ramírez-Rave ◽

María Josefa Bernad-Bernad ◽

Jesús Gracia-Mora ◽

Anatoly K. Yatsimirsky

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

High Surface ◽

Delivery Systems ◽

Surface Reactivity ◽

External Stimulus ◽

Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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