Analytical errors due to biotin interference

2021 ◽  
Vol 157 (2) ◽  
pp. 95-96
Author(s):  
Jesús Letosa-Gaudó ◽  
Francisca González-Rubio ◽  
Ignatios Ioakeim-Skoufa
Keyword(s):  
Author(s):  
Milton C. Weinstein

Cost-effectiveness analysis (CEA) is a method of economic evaluation that can be used to assess the efficiency with which health care technologies use limited resources to produce health outputs. However, inconsistencies in the way that such ratios are constructed often lead to misleading conclusions when CEAs are compared. Some of these inconsistencies, such as failure to discount or to calculate incremental ratios correctly, reflect analytical errors that, if corrected, would resolve the inconsistencies. Others reflect fundamental differences in the viewpoint of the analysis. The perspectives of different decision-making entities can properly lead to different items in the numerator and denominator of the cost-effectiveness (C/E) ratio. Producers and consumers of CEA need to be more conscious of the perspectives of analysis, so that C/E comparisons from a given perspective are based upon a common understanding of the elements that are properly included.


Author(s):  
Jesús Letosa-Gaudó ◽  
Francisca González-Rubio ◽  
Ignatios Ioakeim-Skoufa
Keyword(s):  

1966 ◽  
Vol 20 (3) ◽  
pp. 449-460 ◽  
Author(s):  
K. L. Blaxter ◽  
J. L. Clapperton ◽  
A. K. Martin

1. The results of over 500 determinations of the heat of combustion of the urine produced by cattle and sheep have been analysed statistically. 2. The analytical errors for nitrogen, carbon and heat of combustion were ±0.54, ±1.4 and ±2.2%. The error attached to an estimate of the heat of combustion of the urine produced by an individual sheep in 4 days was ± 10%.3. At the maintenance level of feeding, the heat of combustion of the urine (U kcal/ 100 kcal food) was related to the crude protein content of the diet (P%)by the equationU = 0.25P+1.6with a residual standard deviation of ±0.88 kcal/100 kcal.4. Regression analysis of the relation between the heat of combustion of urine and its N content showed significant differences with diet. The heat of combustion of the urine of sheep was 9.7 kcal/g C and of cattle 10.3 kcal/g C, and did not vary with diet. 5. It is shown that the variation in the heat of combustion of urine/g N and its relative constancy/g C arises largely from variation, from diet to diet, in the proportion of the N excreted as hippurate. 6. The results have been combined with the results of a similar analysis (Blaxter & Clapperton, 1965) of methane production by sheep to show that the ratio of metabolizable energy to digested energy varies very little from mean values of 0.82 for roughages, 0.85 for cereals and 0.79 for oilseed cakes and meals.


Author(s):  
Mitul Navinchandra Chhatriwala ◽  
Dharmik Savjibhai Patel ◽  
Divyal Patel ◽  
Hitesh N Shah

Introduction: Clinical laboratories are judged by its validity, reliability, genuineness or authenticity and its timeliness in reports generating. Repetitively, patients and physicians complain about the time taken by the laboratory for the investigation. The total Turn Around Time (TAT) for laboratory tests includes the entire interval from the order of the test to the awareness of the result by the clinicians. The evaluation and improvement of TAT is crucial for the management of laboratory quality and the satisfaction of patients. Aim: To observe the TAT of common biochemical investigations, to identify reasons for increased TAT and to formulate a plan to rectify increased TAT. Materials and Methods: A hospital based cross-sectional study was conducted at the Clinical Biochemistry Section of the Central Diagnostic Laboratory of Tertiary Care Hospital. TAT data from April 2014 to September 2015 were included in the study. The laboratory technicians and the resident doctors of biochemistry recorded the reasons for the delay of those specimens exceeding the TAT. Data were analysed with the help of statistical software Epi Info 7. Results: The total number of samples received in the biochemistry laboratory were 1,85,658. Out of this, Out Patient Department (OPD) samples were 1,35,022 and Intensive Care Unit (ICU) samples were 50,636. Pre-analytical errors were observed in 670 of ICU samples, which was 1.32% of total samples received and it was higher than the post-analytical errors. In the pre-analytical phase, the most common cause was inaccurate procedures of sample collection. Conclusion: This study demonstrates that the main culprit of increased TAT was delay in the sample transportation and Haemolysed samples. TAT minimisation is a constant procedure for any facility. Every laboratory needs to develop a decent approach for reducing the TAT.


1971 ◽  
Vol 17 (11) ◽  
pp. 1114-1122 ◽  
Author(s):  
C D Russell ◽  
E Cotlove

Abstract Rate equations and rate parameters are determined for the coupled-reaction assay for serum glutamic-oxaloacetic transaminase in which malic dehydrogenase is used. These are used to interpret observed curves of absorbance vs. time, to select optimum substrate concentrations, and to estimate nonrandom analytical errors. A simple, systematic, general approach is presented, which can readily be applied to other enzyme assays in which two or more reactions are coupled. It depends for its simplicity on access to an adequate computing facility.


2018 ◽  
Vol 35 (1) ◽  
pp. 32-42
Author(s):  
Preethi Loganathan ◽  
Sampath Kumar Gasper ◽  
Fathima Kader Afel ◽  
Selvakumar Kandaswamy

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