Cell death–inducing DNA fragmentation factor α–like effector A (CIDEA) gene V115F (G→T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men

Metabolism ◽  
2008 ◽  
Vol 57 (4) ◽  
pp. 502-505 ◽  
Author(s):  
Ling Zhang ◽  
Koichi Miyaki ◽  
Takeo Nakayama ◽  
Masaaki Muramatsu
Keyword(s):  
Metabolic Syndrome ◽  
Cell Death ◽  
Dna Fragmentation ◽  
Japanese Men ◽  
Factor Α

Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis

2012 ◽  
Vol 348 (1) ◽  
pp. 297-304 ◽  
Author(s):  
Naoki Omae ◽  
Minoru Ito ◽  
Syoko Hase ◽  
Michiaki Nagasawa ◽  
Junichi Ishiyama ◽  
...  
Keyword(s):  
Cell Death ◽  
Palmitic Acid ◽  
Dna Fragmentation ◽  
Β Cells ◽  
Induced Apoptosis ◽  
Factor Α

scholarly journals The effects of cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC) on milk lipid synthesis in mammary glands of dairy cows

2017 ◽  
Vol 100 (5) ◽  
pp. 4014-4024 ◽  
Author(s):  
Yang Yang ◽  
Ye Lin ◽  
Xiaoyu Duan ◽  
He Lv ◽  
Weinan Xing ◽  
...  
Keyword(s):  
Cell Death ◽  
Dairy Cows ◽  
Dna Fragmentation ◽  
Lipid Synthesis ◽  
Mammary Glands ◽  
Milk Lipid ◽  
Factor Α

scholarly journals Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, α-subunit-like effector A

2007 ◽  
Vol 196 (3) ◽  
pp. 547-557 ◽  
Author(s):  
Lovisa Lundholm ◽  
Milica Putnik ◽  
Michio Otsuki ◽  
Sandra Andersson ◽  
Claes Ohlsson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Adipose Tissue ◽  
Glutathione Peroxidase ◽  
Dna Fragmentation ◽  
Fat Mass ◽  
White Adipose Tissue ◽  
Α Subunit ◽  
Glutathione Peroxidase 3 ◽  
Factor Α

Obesity has become a major health problem in many parts of the world. Estrogens are known to reduce adipose tissue mass in both humans and animals but the molecular mechanisms are not well characterized. We used gene expression profiling to study long-term effects of estrogen on gene expression in mouse white adipose tissue and hypothalamus. Overall, the effects of estrogen on hypothalamic gene expression were much smaller than the corresponding effects on white adipose tissue gene expression. We characterize in detail estrogenic regulation of glutathione peroxidase 3 (GPX3). Our studies suggest that GPX3 is a direct estrogen receptor α target gene in white adipose tissue. Since obesity is correlated with oxidative stress, and GPX3 has been demonstrated to be lower in obesity and higher after weight loss, we hypothesize that GPX3 is one important mediator of effects of estrogen in relation to fat mass. Additional genes that were affected by estrogen in adipose tissue include cell death-inducing DNA fragmentation factor, α-subunit-like effector A (CIDEA), a gene shown to be related to body fat in mice. We conclude that estrogen has large effects on gene expression in white adipose tissue and hypothesize that GPX3 and CIDEA could be important mediators of the effects of estrogen on fat mass.

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