Testosterone, dihydrotestosterone, bone density, and hip fracture risk among older men: The Cardiovascular Health Study

Metabolism ◽  
2021 ◽  
Vol 114 ◽  
pp. 154399
Author(s):  
Emily A. Rosenberg ◽  
Petra Bůžková ◽  
Howard A. Fink ◽  
John A. Robbins ◽  
Molly M. Shores ◽  
...  
2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Elsa S. Strotmeyer ◽  
Aruna Kamineni ◽  
Jane A. Cauley ◽  
John A. Robbins ◽  
Linda F. Fried ◽  
...  

Type 2 diabetes is associated with higher fracture risk. Diabetes-related conditions may account for this risk. Cardiovascular Health Study participants (N=5641; 42.0% men; 15.5% black; 72.8±5.6 years) were followed 10.9±4.6 years. Diabetes was defined as hypoglycemic medication use or fasting glucose (FG)≥126 mg/dL. Peripheral artery disease (PAD) was defined as ankle-arm index <0.9. Incident hip fractures were from medical records. Crude hip fracture rates (/1000 person-years) were higher for diabetic vs. non-diabetic participants with BMI <25 (13.6, 95% CI: 8.9–20.2 versus 11.4, 95% CI: 10.1–12.9) and BMI≥25 to <30 (8.3, 95% CI: 5.7–11.9 versus 6.6, 95% CI: 5.6–7.7), but similar for BMI≥30. Adjusting for BMI, sex, race, and age, diabetes was related to fractures (HR = 1.34; 95% CI: 1.01–1.78). PAD (HR = 1.25 (95% CI: 0.92–1.57)) and longer walk time (HR = 1.07 (95% CI: 1.04–1.10)) modified the fracture risk in diabetes (HR = 1.17 (95% CI: 0.87–1.57)). Diabetes was associated with higher hip fracture risk after adjusting for BMI though this association was modified by diabetes-related conditions.


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Vol 29 (5) ◽  
pp. 1061-1066 ◽  
Author(s):  
Joshua I Barzilay ◽  
Petra Bůžková ◽  
Susan J Zieman ◽  
Jorge R Kizer ◽  
Luc Djoussé ◽  
...  

2013 ◽  
Vol 24 (12) ◽  
pp. 2993-3000 ◽  
Author(s):  
J. I. Barzilay ◽  
P. Bůžková ◽  
Z. Chen ◽  
I. H. de Boer ◽  
L. Carbone ◽  
...  

2012 ◽  
Vol 27 (11) ◽  
pp. 2314-2324 ◽  
Author(s):  
Lang Yang ◽  
Annabel C Burton ◽  
Mike Bradburn ◽  
Carrie M Nielson ◽  
Eric S Orwoll ◽  
...  

2007 ◽  
Vol 18 (5) ◽  
pp. 593-602 ◽  
Author(s):  
K. J. Mukamal ◽  
J. A. Robbins ◽  
J. A. Cauley ◽  
L. M. Kern ◽  
D. S. Siscovick

2019 ◽  
Vol 34 (4) ◽  
pp. 643-652 ◽  
Author(s):  
Laura D Carbone ◽  
Petra Bůžková ◽  
Howard A Fink ◽  
Mattie Raiford ◽  
Brian Le ◽  
...  

2016 ◽  
Vol 31 (8) ◽  
pp. 1550-1558 ◽  
Author(s):  
Jan Borggrefe ◽  
Timm de Buhr ◽  
Smriti Shrestha ◽  
Lynn M Marshall ◽  
Eric Orwoll ◽  
...  

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