Albuminuria is associated with hip fracture risk in older adults: the cardiovascular health study

Type 2 diabetes is associated with higher fracture risk. Diabetes-related conditions may account for this risk. Cardiovascular Health Study participants (N=5641; 42.0% men; 15.5% black; 72.8±5.6 years) were followed 10.9±4.6 years. Diabetes was defined as hypoglycemic medication use or fasting glucose (FG)≥126 mg/dL. Peripheral artery disease (PAD) was defined as ankle-arm index <0.9. Incident hip fractures were from medical records. Crude hip fracture rates (/1000 person-years) were higher for diabetic vs. non-diabetic participants with BMI <25 (13.6, 95% CI: 8.9–20.2 versus 11.4, 95% CI: 10.1–12.9) and BMI≥25 to <30 (8.3, 95% CI: 5.7–11.9 versus 6.6, 95% CI: 5.6–7.7), but similar for BMI≥30. Adjusting for BMI, sex, race, and age, diabetes was related to fractures (HR = 1.34; 95% CI: 1.01–1.78). PAD (HR = 1.25 (95% CI: 0.92–1.57)) and longer walk time (HR = 1.07 (95% CI: 1.04–1.10)) modified the fracture risk in diabetes (HR = 1.17 (95% CI: 0.87–1.57)). Diabetes was associated with higher hip fracture risk after adjusting for BMI though this association was modified by diabetes-related conditions.

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Circulating Levels of Carboxy-Methyl-Lysine (CML) Are Associated With Hip Fracture Risk: The Cardiovascular Health Study

Journal of Bone and Mineral Research ◽

10.1002/jbmr.2123 ◽

2014 ◽

Vol 29 (5) ◽

pp. 1061-1066 ◽

Cited By ~ 26

Author(s):

Joshua I Barzilay ◽

Petra Bůžková ◽

Susan J Zieman ◽

Jorge R Kizer ◽

Luc Djoussé ◽

...

Keyword(s):

Hip Fracture ◽

Fracture Risk ◽

Cardiovascular Health ◽

Health Study ◽

Cardiovascular Health Study ◽

Hip Fracture Risk ◽

Circulating Levels ◽

Carboxy Methyl

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Testosterone, dihydrotestosterone, bone density, and hip fracture risk among older men: The Cardiovascular Health Study

Metabolism ◽

10.1016/j.metabol.2020.154399 ◽

2021 ◽

Vol 114 ◽

pp. 154399

Author(s):

Emily A. Rosenberg ◽

Petra Bůžková ◽

Howard A. Fink ◽

John A. Robbins ◽

Molly M. Shores ◽

...

Keyword(s):

Hip Fracture ◽

Bone Density ◽

Fracture Risk ◽

Cardiovascular Health ◽

Older Men ◽

Health Study ◽

Cardiovascular Health Study ◽

Hip Fracture Risk

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Cardiovascular autonomic nervous system function and hip fracture risk: the Cardiovascular Health Study

Archives of Osteoporosis ◽

10.1007/s11657-021-01028-y ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Phyllis K. Stein ◽

Petra Buzkova ◽

Howard A. Fink ◽

John A. Robbins ◽

Kenneth J. Mukamal ◽

...

Keyword(s):

Nervous System ◽

Autonomic Nervous System ◽

Hip Fracture ◽

Fracture Risk ◽

Cardiovascular Health ◽

Health Study ◽

Cardiovascular Health Study ◽

System Function ◽

Autonomic Nervous System Function ◽

Nervous System Function

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Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-1152 ◽

2013 ◽

Vol 98 (8) ◽

pp. 3323-3331 ◽

Cited By ~ 29

Author(s):

Anna Jovanovich ◽

Petra Bùžková ◽

Michel Chonchol ◽

John Robbins ◽

Howard A. Fink ◽

...

Keyword(s):

Older Adults ◽

Hip Fracture ◽

Lumbar Spine ◽

Cardiovascular Health ◽

Fibroblast Growth Factor 23 ◽

Community Dwelling ◽

Health Study ◽

Cardiovascular Health Study ◽

Mineral Density ◽

Total Hip

Context: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that also inhibits calcitriol synthesis. Objective: Our objective was to evaluate the relationships of plasma FGF23 concentrations with bone mineral density (BMD) and hip fracture in community-dwelling older adults. Design and Setting: Linear regression and Cox proportional hazard models were used to examine the associations of plasma FGF23 concentrations with BMD and incident hip fracture, respectively. Analyses were also stratified by chronic kidney disease. Participants: Participants included 2008 women and 1329 men ≥65 years from the 1996 to 1997 Cardiovascular Health Study visit. Main Outcome Measures: Dual x-ray absorptiometry measured total hip (TH) and lumbar spine (LS) BMD in 1291 participants. Hip fracture incidence was assessed prospectively through June 30, 2008 by hospitalization records in all participants. Results: Women had higher plasma FGF23 concentrations than men (75 [56–107] vs 66 [interquartile range = 52–92] relative units/mL; P < .001). After adjustment, higher FGF23 concentrations were associated with greater total hip and lumbar spine BMD in men only (β per doubling of FGF23 = 0.02, with 95% confidence interval [CI] = 0.001–0.04 g/cm2, and 0.03 with 95% CI = 0.01–0.06 g/cm2). During 9.6 ± 5.1–11.0 years of follow-up, 328 hip fractures occurred. Higher FGF23 concentrations were not associated with hip fracture risk in women or men (adjusted hazard ratio = 0.95, with 95% CI = 0.78–1.15, and 1.09 with 95% CI = 0.82–1.46 per doubling of FGF23). Results did not differ by chronic kidney disease status (P > .4 for interactions). Conclusions: In this large prospective cohort of community-dwelling older adults, higher FGF23 concentrations were weakly associated with greater lumbar spine and total hip BMD but not with hip fracture risk.

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