Potential implications of lipid nanoparticles in the pathogenesis of myocarditis associated with the use of mRNA vaccines against SARS-CoV-2

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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Microfluidic-Enabled Seamless Manufacture of RNA-Lipid Nanoparticles from Discovery through Pre-Clinical Development

10.26226/morressier.57d6b2bfd462b8028d88cc7e ◽

2016 ◽

Author(s):

Andrea Armstead

Keyword(s):

Lipid Nanoparticles ◽

Clinical Development

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Optimization and evaluation of topical gel containing solid lipid nanoparticles loaded with luliconazole and its anti-fungal activity

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp2.169 ◽

2020 ◽

Vol 12 (sp2) ◽

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Topical Gel ◽

Solid Lipid ◽

Fungal Activity ◽

Anti Fungal

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Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.2.3 ◽

2009 ◽

Vol 2 (2) ◽

pp. 509-516

Author(s):

S. Pragati ◽

S. Kuldeep ◽

S. Ashok ◽

M. Satheesh

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Large Scale ◽

Colloidal Particles ◽

Scale Up ◽

Lipid Nanoparticles ◽

Scale Production ◽

Research Activity ◽

New Approach ◽

Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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Surface Modified Nanoparticulate Carriers for the Targeted Treatment of Breast Cancer

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.1.2 ◽

2015 ◽

Vol 8 (1) ◽

pp. 2698-2714

Author(s):

Neeraj Mishra ◽

Tejinder Singh ◽

Nidhi ◽

Supandeep Singh Hallan ◽

Veerpal Kaur

Keyword(s):

Breast Cancer ◽

Tumor Targeting ◽

Lipid Nanoparticles ◽

Targeted Treatment ◽

Therapeutic Effects ◽

Target Drug Delivery ◽

Target Drug ◽

Therapeutic Outcomes ◽

Lipid Nanocarriers ◽

Surface Modified

Breast cancer left overs one of the greatest common metastasis disease in females. Advanced diagnostic devices and better understanding of tumour biology can extend the better therapeutic outcomes. Nanotechnology is a tool that helps in cancer diagnosis and treatment therapy. Many nanocarriers such as solid lipid nanoparticles, magnetic nanoparticles, nanocrystals, nanogels, nano-lipid nanocarriers, biodegradable nanoparticles, liposomes, and dendrimers are introduced to improve the therapeutic efficacy of antineoplastic agents. Surface modified target drug delivery system has the potential to increase the therapeutic effects and also reduce the cytotoxicity of breast cancer. Different approaches have been explored for treatment of breast cancer. This review describes the recent advances in the development of nanocarriers used for the targeted treatment of breast cancer. It also focuses on etiology, risk factor and conventional therapy of breast cancer. KEYWORDS: Breast Cancer; Nano-carriers; Tumor Targeting; Ligands; Receptor.

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Preparation, Characterization and In-vitro release of Piroxicam-loaded Solid Lipid Nanoparticles

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2010.3.3.12 ◽

2010 ◽

Vol 3 (3) ◽

pp. 1136-1146

Author(s):

V K Verma ◽

Ram A

Keyword(s):

Electron Microscopy ◽

Particle Size ◽

Solid Lipid Nanoparticles ◽

In Vitro Release ◽

Entrapment Efficiency ◽

Lipid Nanoparticles ◽

Diffusion Method ◽

Solid Lipid ◽

Vitro Release

Solid lipid nanoparticles (SLNs) of piroxicam where produced by solvent emulsification diffusion method in a solvent saturated system. The SLNs where composed of tripamitin lipid, polyvinyl alcohol (PVAL) stabilizer, and solvent ethyl acetate. All the formulation were subjected to particle size analysis, zeta potential, drug entrapment efficiency, percent drug loading determination and in-vitro release studies. The SLNs formed were nano-size range with maximum entrapment efficiency. Formulation with 435nm in particle size and 85% drug entrapment was subjected to scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for surface morphology, differential scanning calorimetry (DSC) for thermal analysis and short term stability studies. SEM and TEM confirm that the SLNs are nanometric size and circular in shape. The drug release behavior from SLNs suspension exhibited biphasic pattern with an initial burst and prolong release over 24 h.

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