scholarly journals Is there any relationship between serum zinc levels and angiotensin-converting enzyme 2 gene expression in patients with coronavirus disease 2019?

Meta Gene ◽  
2021 ◽  
pp. 100991
Author(s):  
Zahra Bagheri-Hosseinabadi ◽  
Ali Pirsadeghi ◽  
Amir Rahnama ◽  
Fatemeh Bahrehmand ◽  
Mitra Abbasifard
Keyword(s):  
Gene Expression ◽  
Angiotensin Converting Enzyme ◽  
Serum Zinc ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Review: Pengaruh Tanaman Obat Yang Beraktivitas Hipertensi Terhadap Ekspresi Gen Reseptor ACE-1 dan ACE 2

2021 ◽  
Vol 7 (1) ◽  
pp. 9-31
Author(s):  
Nisa Nur Afifah ◽  
Yani Mulyani ◽  
Ari Yuniarto
Keyword(s):  
Gene Expression ◽  
Medicinal Plant ◽  
Angiotensin Converting Enzyme ◽  
Allium Cepa ◽  
Allium Sativum ◽  
Ace Inhibitor ◽  
Hibiscus Sabdariffa ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Plant Gene Expression

Hipertensi adalah salah satu penyakit dengan angka kesakitan dan kematian yang terus meningkat, termasuk di Indonesia. Dalam mengatasi hipertensi obat-obatan seperti ACE inhibitor berperan dalam menurunkan tekanan darah diastol dan sistol, namun tanaman obat seperti ekstrak buah hawthorn, buah zaitun (Olea europaea L.), Hibiscus Sabdariffa, Allium Sativum dan Allium Cepa juga memiliki efek sebagai antihipertensi dengan harga yang relatif murah, mudah didapat, efek samping yang lebih rendah dibandingkan dengan obat sintesis atau kimia lainnya. Review jurnal ini ditujukan untuk mengetahui berbagai tanaman obat yang memiliki aktivitas hipertensi dan berpengaruh terhadap ekspresi gen reseptor hipertensi ACE1 dan ACE2. Penelusuran referensi dilakukan melalui database PubMed, Science Direct, dan Google Scholar, dengan kata kunci “Medicinal Plant”, “Gene expression”, “Angiotensin Converting Enzyme 1”, “Angiotensin Converting Enzyme 2”, dan“Antihypertension”. Tanaman obat digunakan sebagai terapi alternatif penurun tekanan darah tinggi dan merupakan salah satu cara pengobatan non farmakologis hipertensi. Hal ini menunjukkan bahwa tanaman obat memiliki pengaruh dalam menurunkan tekanan darah tinggi karena kandungan senyawa yang ada dalam masing-masing tanaman sehingga mampu menghambat reseptor hipertensi ACE1 dan ACE2 dengan berbagai metode ekspresi gen. Banyak tanaman obat yang telah diteliti memiliki aktivitas sebagai antihipertensi. Dari 14 tanaman obat dengan aktivitas sebagai anti hipertensi, sebanyak 90% tanaman berpengaruh terhadap ekspresi gen Angiotensin Converting Enzyme 1 (ACE 1), dan sebanyak 10% tanaman memiliki pengaruh terhadap Angiotensin Converting Enzyme 2 (ACE 2). Tanaman obat yang telah ditemukan dan memiliki aktivitas terhadap ekspresi gen Angiotensin Converting Enzyme 1 (ACE 1) paling banyak merupakan tanaman obat dengan family Poaceae, Oleaceae, dan Zingiberaceae.

scholarly journals Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers With COVID-19Pneumonia

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 796
Author(s):  
Francesca Lunardi ◽  
Francesco Fortarezza ◽  
Luca Vedovelli ◽  
Federica Pezzuto ◽  
Annalisa Boscolo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Angiotensin Converting Enzyme ◽  
Lung Tissue ◽  
Smoking Habit ◽  
Critical Role ◽  
Case Series ◽  
Bayesian Regression ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Susceptibility To Infection

Angiotensin-converting enzyme 2 (ACE-2) is the main cell entry receptor for severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2), thus playing a critical role in causing Coronavirus disease 2019 (COVID-19). The role of smoking habit in the susceptibility to infection is still controversial. In this study we correlated lung ACE-2 gene expression with several clinical/pathological data to explore susceptibility to infection. This is a retrospective observational study on 29 consecutive COVID-19 autopsies. SARS-CoV-2 genome and ACE-2 mRNA expression were evaluated by real-time polymerase chain reaction in lung tissue samples and correlated with several data with focus on smoking habit. Smoking was less frequent in high than low ACE-2 expressors (p = 0.014). A Bayesian regression also including age, gender, hypertension, and virus quantity confirmed that smoking was the most probable risk factor associated with low ACE-2 expression in the model. A direct relation was found between viral quantity and ACE-2 expression (p = 0.028). Finally, high ACE-2 expressors more frequently showed a prevalent pattern of vascular injury than low expressors (p = 0.049). In conclusion, ACE-2 levels were decreased in the lung tissue of smokers with severe COVID-19 pneumonia. These results point out complex biological interactions between SARS-CoV-2 and ACE-2 particularly concerning the aspect of smoking habit and need larger prospective case series and translational studies.

scholarly journals Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

JAMA ◽  
2020 ◽  
Vol 323 (23) ◽  
pp. 2427 ◽  
Author(s):  
Supinda Bunyavanich ◽  
Anh Do ◽  
Alfin Vicencio
Keyword(s):  
Gene Expression ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2
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