Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19

Gene Expression Profile ◽

Expression Profile ◽

Human Lung ◽

Converting Enzyme ◽

Human Lung Tissue ◽

Human Male ◽

Ace2 Gene

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurs through binding and internalization of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell membrane. Pathological changes are caused by damage and failure of vital organs that express high levels of ACE2, including the lungs, the heart and the kidneys. The aim of this study was to investigate ACE2 gene expression in the human male urogenital tract using a public database. Methods A search of transcriptomic datasets from a database to investigate ACE2 gene expression in human urogenital tract tissue. Results The gene expression profile demonstrated that ACE2 gene expression was higher in human kidney cortex and testis than human lung tissue. The gene expression profile demonstrated that ACE2 gene expression in the human bladder and prostate was comparable to human lung tissue. Conclusions Male urogenital tissues are directly susceptible to SARS-CoV-2 infection through the expression of ACE2. Moreover, the SARS-Cov-2/ACE2 interaction may disturb the male genital and reproductive functions.

Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes

Circulation Journal ◽

10.1253/circj.72.1346 ◽

2008 ◽

Vol 72 (8) ◽

pp. 1346-1350 ◽

Cited By ~ 28

Author(s):

Megumi Yamamuro ◽

Michihiro Yoshimura ◽

Masafumi Nakayama ◽

Koji Abe ◽

Hitoshi Sumida ◽

...

Keyword(s):

Gene Expression ◽

Angiotensin Ii ◽

Neonatal Rat ◽

Converting Enzyme ◽

Rat Cardiomyocytes ◽

Expression Levels ◽

Neonatal Rat Cardiomyocytes ◽

Gene Expression Levels

Angiotensin-converting enzyme 2 (ACE2) gene and protein expression in diabetic patients without nephropathy

Kidney International ◽

10.1038/ki.2009.50 ◽

2009 ◽

Vol 75 (10) ◽

pp. 1118-1119 ◽

Cited By ~ 1

Author(s):

Olusegun L. Amao

Keyword(s):

Protein Expression ◽

Diabetic Patients ◽

Converting Enzyme ◽

Gene And Protein Expression ◽

Ace2 Gene

Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2017.00027 ◽

2017 ◽

Vol 4 ◽

Cited By ~ 38

Author(s):

Maria A. Zuriaga ◽

Jose J. Fuster ◽

Noyan Gokce ◽

Kenneth Walsh

Keyword(s):

Gene Expression ◽

Adipose Tissue ◽

White Adipose Tissue ◽

Subcutaneous White Adipose Tissue ◽

Adipose Tissue Depots

Olmesartan Blocks Advanced Glycation End Products-Induced VCAM-1 Gene Expression in Mesangial Cells by Restoring Angiotensin-Converting Enzyme 2 Level

Hormone and Metabolic Research ◽

10.1055/s-0033-1361114 ◽

2013 ◽

Vol 46 (06) ◽

pp. 379-383

Author(s):

Y. Ishibashi ◽

T. Matsui ◽

S. Yamagishi

Keyword(s):

Gene Expression ◽

Advanced Glycation End Products ◽

Mesangial Cells ◽

Converting Enzyme ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

Review: Pengaruh Tanaman Obat Yang Beraktivitas Hipertensi Terhadap Ekspresi Gen Reseptor ACE-1 dan ACE 2

Jurnal Mandala Pharmacon Indonesia ◽

10.35311/jmpi.v7i1.64 ◽

2021 ◽

Vol 7 (1) ◽

pp. 9-31

Author(s):

Nisa Nur Afifah ◽

Yani Mulyani ◽

Ari Yuniarto

Keyword(s):

Gene Expression ◽

Medicinal Plant ◽

Allium Cepa ◽

Allium Sativum ◽

Ace Inhibitor ◽

Hibiscus Sabdariffa ◽

Converting Enzyme ◽

Plant Gene Expression

Hipertensi adalah salah satu penyakit dengan angka kesakitan dan kematian yang terus meningkat, termasuk di Indonesia. Dalam mengatasi hipertensi obat-obatan seperti ACE inhibitor berperan dalam menurunkan tekanan darah diastol dan sistol, namun tanaman obat seperti ekstrak buah hawthorn, buah zaitun (Olea europaea L.), Hibiscus Sabdariffa, Allium Sativum dan Allium Cepa juga memiliki efek sebagai antihipertensi dengan harga yang relatif murah, mudah didapat, efek samping yang lebih rendah dibandingkan dengan obat sintesis atau kimia lainnya. Review jurnal ini ditujukan untuk mengetahui berbagai tanaman obat yang memiliki aktivitas hipertensi dan berpengaruh terhadap ekspresi gen reseptor hipertensi ACE1 dan ACE2. Penelusuran referensi dilakukan melalui database PubMed, Science Direct, dan Google Scholar, dengan kata kunci “Medicinal Plant”, “Gene expression”, “Angiotensin Converting Enzyme 1”, “Angiotensin Converting Enzyme 2”, dan“Antihypertension”. Tanaman obat digunakan sebagai terapi alternatif penurun tekanan darah tinggi dan merupakan salah satu cara pengobatan non farmakologis hipertensi. Hal ini menunjukkan bahwa tanaman obat memiliki pengaruh dalam menurunkan tekanan darah tinggi karena kandungan senyawa yang ada dalam masing-masing tanaman sehingga mampu menghambat reseptor hipertensi ACE1 dan ACE2 dengan berbagai metode ekspresi gen. Banyak tanaman obat yang telah diteliti memiliki aktivitas sebagai antihipertensi. Dari 14 tanaman obat dengan aktivitas sebagai anti hipertensi, sebanyak 90% tanaman berpengaruh terhadap ekspresi gen Angiotensin Converting Enzyme 1 (ACE 1), dan sebanyak 10% tanaman memiliki pengaruh terhadap Angiotensin Converting Enzyme 2 (ACE 2). Tanaman obat yang telah ditemukan dan memiliki aktivitas terhadap ekspresi gen Angiotensin Converting Enzyme 1 (ACE 1) paling banyak merupakan tanaman obat dengan family Poaceae, Oleaceae, dan Zingiberaceae.

Sex-Specific Changes in Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression and Enzyme Activity at Birth and Over the First Year of Life

Reproductive Sciences ◽

10.1177/1933719115597760 ◽

2015 ◽

Vol 23 (2) ◽

pp. 200-210 ◽

Cited By ~ 11

Author(s):

Kai Chen ◽

Jianli Bi ◽

Yixin Su ◽

Mark C. Chappell ◽

James C. Rose

Keyword(s):

Gene Expression ◽

Enzyme Activity ◽

First Year ◽

Converting Enzyme ◽

First Year Of Life

Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320311412809 ◽

2011 ◽

Vol 12 (4) ◽

pp. 456-461 ◽

Cited By ~ 20

Author(s):

Masanobu Yamazato ◽

Anderson J Ferreira ◽

Yoriko Yamazato ◽

Carlos Diez-Freire ◽

Lihui Yuan ◽

...

Keyword(s):

Heart Rate ◽

Gene Transfer ◽

Spontaneously Hypertensive Rats ◽

Nucleus Tractus Solitarius ◽

Converting Enzyme ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Ace2 Gene

The renin–angiotensin system (RAS) in the nucleus tractus solitarius (NTS) is an important modulator of the baroreceptor heart rate reflex. This study tested the hypothesis that angiotensin-converting enzyme 2 (ACE2) expression is decreased in the NTS of spontaneously hypertensive rats (SHRs) and that its gene transfer in this nucleus would lead to beneficial effects on baroreflex function since this enzyme is key in the regulation of the vasoprotective axis of the RAS. ACE2 protein levels and its activity were significantly decreased in the NTS of SHRs compared to normotensive Wistar-Kyoto (WKY) control rats. Rats instrumented with radio-telemetry transducers received NTS microinjection of either Lenti-ACE2 (Lentiviral vector-mediated gene transfer of ACE2) or lenti-GFP (green fluorescent protein). The ACE2 gene transfer into the NTS resulted in long-term overexpression of ACE2. This was associated with a 60% increase in heart rate baroreflex sensitivity in the lenti-ACE2 injected SHRs compared with the lenti-GFP injected control SHRs (0.27 ± 0.02 ms/mmHg in lenti-GFP rats vs. 0.44 ± 0.07 ms/mmHg in lenti-ACE2 rats). These observations demonstrate that ACE2 gene transfer overcomes its intrinsic decrease in the NTS of SHRs and improves baroreceptor heart rate reflex.