Effect of imidazolium-based ionic liquid on the antibacterial activity of an expired drug rifampicin

The synthesis of some 1,3-diazoles and thiazoles was realized in different conditions:a) In the presence of PTSA or sulfuric acid as catalyst we obtained only diazole products(4a-d).b) In basic medium such as DABCO or sodium hydroxide and ionic liquid afforded thiazoles.c) Both products, diazoles and thiazoles were collected when using methanol as catalyst and solvent.All structures were confirmed by IR, 1H NMR and 13C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against Escherichia Coli (ATCC: 25922) and Serratia marcescens (ATCC: 13880) as gram negative bacteria, Bacillus sabtilis (ATCC: 6633) and Staphylococcus aureus (ATCC: 6338) as gram positive bacteria. Some of these products exhibit good activities to significant antibacterial activity.

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Different Molecular Weight Chitosans Prepared via the Ionic Liquid Hydrolysis and their Antibacterial Activity

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.730.127 ◽

2017 ◽

Vol 730 ◽

pp. 127-134 ◽

Cited By ~ 1

Author(s):

Ran Ran Fu ◽

Xiu Jie Ji ◽

Yan Fei Ren ◽

Gang Wang ◽

Bo Wen Cheng

Keyword(s):

Molecular Weight ◽

Antibacterial Activity ◽

Ionic Liquid ◽

Antimicrobial Properties ◽

Aqueous System ◽

Titration Method ◽

Obvious Effect ◽

E Coli ◽

Hydrolysis Method ◽

Different Molecular Weight

The hydrolysis effect of ionic liquid glycine chloride [Gly]Cl aqueous system without any catalyst on the degradation for chitosan were studied. The molecular weight (Mw) and degree of deacetylation (DD) of degraded products were tested via the viscometric method and the titration method, respectively. The structure of the raw and degraded chitosans were assessed through Fourier transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). Besides, the antibacterial effects of different Mw chitosans to Escherichia coli and Staphylococcus aureus were evaluated. The results showed that [Gly]Cl aqueous solution was of good assistant degradation effect for chitosan and different molecular weight (300-800 kDa) chitosans were obtained with different processing time via the ionic liquid hydrolysis method. The DD of degraded chitosans tested from titration method was almost unchanged by the treatment. The FTIR and XRD results showed that the ionic liquid degradation had no obvious effect on the molecular structure of chitosan. Besides, the antibacterial activity was closely relevant to the chitosan concentration and Mw. When the concentration was greater than 0.005% (w/v), chitosan began to show strong antibacterial activity. Molecular weight of 636 kDa exhibited commendable antimicrobial properties to E. coli and S. aureus simultaneously.

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Ionic liquid catalyzed one-pot multi-component synthesis, characterization and antibacterial activity of novel chromeno[2,3-d]pyrimidin-8-amine derivatives

Journal of Molecular Structure ◽

10.1016/j.molstruc.2012.02.044 ◽

2012 ◽

Vol 1017 ◽

pp. 60-64 ◽

Cited By ~ 30

Author(s):

Sankari Kanakaraju ◽

Bethanamudi Prasanna ◽

Srinivas Basavoju ◽

G.V.P. Chandramouli

Keyword(s):

Antibacterial Activity ◽

Ionic Liquid ◽

One Pot

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Enhanced Antibacterial Activity of a Novel Biocompatible Triarylmethane based Ionic Liquid-Graphene Oxide Nanocomposite

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2021.111729 ◽

2021 ◽

pp. 111729

Author(s):

Susmita Prusty ◽

Kunal Pal ◽

Debbethi Bera ◽

Anindita Paul ◽

Madhubroto Mukherjee ◽

...

Keyword(s):

Antibacterial Activity ◽

Ionic Liquid ◽

Graphene Oxide

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A microscopy method for scanning transmission electron microscopy imaging of the antibacterial activity of polymeric nanoparticles on a biofilm with an ionic liquid

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.33680 ◽

2016 ◽

Vol 105 (6) ◽

pp. 1432-1437 ◽

Cited By ~ 5

Author(s):

Chisato Takahashi ◽

Shunsuke Muto ◽

Hiromitsu Yamamoto

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Antibacterial Activity ◽

Ionic Liquid ◽

Scanning Transmission Electron Microscopy ◽

Polymeric Nanoparticles ◽

Microscopy Imaging ◽

Transmission Electron ◽

Scanning Transmission ◽

Microscopy Method

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Structure–Antibacterial Activity Relationships of Imidazolium-Type Ionic Liquid Monomers, Poly(ionic liquids) and Poly(ionic liquid) Membranes: Effect of Alkyl Chain Length and Cations

ACS Applied Materials & Interfaces ◽

10.1021/acsami.6b03391 ◽

2016 ◽

Vol 8 (20) ◽

pp. 12684-12692 ◽

Cited By ~ 110

Author(s):

Zhiqiang Zheng ◽

Qiming Xu ◽

Jiangna Guo ◽

Jing Qin ◽

Hailei Mao ◽

...

Keyword(s):

Antibacterial Activity ◽

Ionic Liquid ◽

Ionic Liquids ◽

Chain Length ◽

Alkyl Chain ◽

Alkyl Chain Length ◽

Liquid Membranes ◽

Poly Ionic Liquid

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Ionic Liquid–Stabilized Titania Quantum Dots Applied in Adhesive Resin

Journal of Dental Research ◽

10.1177/0022034519835203 ◽

2019 ◽

Vol 98 (6) ◽

pp. 682-688 ◽

Cited By ~ 10

Author(s):

I.M. Garcia ◽

V.S. Souza ◽

C. Hellriegel ◽

J.D. Scholten ◽

F.M. Collares

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Quantum Dots ◽

Antibacterial Activity ◽

Ionic Liquid ◽

Sol Gel ◽

Adhesive Resin ◽

Transmission Electron ◽

Polymerization Behavior

Quantum dots (QDs; 1 to 10 nm) were recently synthesized by sol-gel and used as nonagglomerated nanoparticles in adhesive resin. The sol-gel process presented a low yield and resulted in a liquid product without stability. In this study, an imidazolium ionic liquid (IL; 1- n-butyl-3-methylimidazolium tetrafluoroborate, BMI.BF4) was used as stabilizing agent to synthesize titanium dioxide QDs (TiO2QDs/BMI.BF4) via a chemical route. The product was isolated as powder after washing, centrifuging, and drying. An experimental adhesive resin was formulated by mixing methacrylate monomers and a photoinitiator system. The TiO2QDs/BMI.BF4 powder was incorporated at 2.5 (G2.5%) and 5 (G5%) wt% in the adhesive resin, and one group remained without TiO2QDs/BMI.BF4 powder as the control (Gctrl). The TiO2QDs/BMI.BF4 powder was analyzed by micro-Raman spectroscopy, thermogravimetry, and transmission electron microscopy. The dispersion of TiO2QDs/BMI.BF4 powder was analyzed in the polymerized adhesive resin with transmission electron microscopy and fluorescence microscopy. The adhesive resins were evaluated for immediate and long-term antibacterial activity, cytotoxicity, polymerization behavior, degree of conversion, softening in solvent, immediate and long-term microtensile bond strength, and fracture pattern. The TiO2QDs/BMI.BF4 powder showed peaks of anatase and rutile and 26 wt% of BMI.BF4. TiO2QDs/BMI.BF4 presented a minimum size of 1.19 nm, a maximum size of 7.11 nm, and a mean ± SD size of 3.54 ± 1.08 nm. TiO2QDs/BMI.BF4 was dispersed in the adhesive resin without agglomeration, presenting intermittent luminescence by blinking. The addition of any tested concentration of TiO2QDs/BMI.BF4 powder provided immediate and long-term antibacterial activity without cytotoxic effect against the pulp fibroblasts. Furthermore, compared with Gctrl, G2.5% showed reliable polymerization behavior and degree of conversion without differences for softening in solvent with maintenance of bond adhesion to tooth immediately and over time. Thus, the incorporation of 2.5 wt% of TiO2QDs/BMI.BF4 in adhesive resin showed reliable physical, chemical, and biological properties.

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