scholarly journals Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients

2014 ◽  
Vol 9 (3) ◽  
pp. 727-739 ◽  
Author(s):  
Falin Qu ◽  
Renli Li ◽  
Xianli He ◽  
Qiucheng Li ◽  
Shuang Xie ◽  
...  
2013 ◽  
Vol 23 (2) ◽  
pp. 66-70
Author(s):  
Albertas Daukša ◽  
Antanas Gulbinas ◽  
Aurelija Kazlauskaitė ◽  
Johannes Oldenburg ◽  
Osman El-Maarri

Gastric cancers are usually diagnosed at an advanced stage in the progression of the disease, thus reducing the survival chances of the patients. Non-invasive early detection would greatly enhance therapy and survival rates. For this aim, we investigated tumor suppressor genes CDKN2A/p16, RARBeta, TNFRSF10C, APC, ACIN1, DAPK1, 3OST2, BCL2 and CD44 for methylation changes in peripheral blood leukocytes of gastric cancer patients. This study shows that methylation changes in peripheral blood leukocyte DNA could provide a promising method for the early detection of gastric cancer. However, larger studies are essential to explore the clinical usefulness of a peripheral blood leukocyte DNA methylation based tests for non-invasive early detection of gastric cancer.


Oncotarget ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 5137-5154 ◽  
Author(s):  
Xiaoting Jiang ◽  
Zhengchuang Liu ◽  
Yingjie Xia ◽  
Jungang Luo ◽  
Ji Xu ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0121559 ◽  
Author(s):  
Xiaojing Cheng ◽  
Zhixue Zheng ◽  
Zhaode Bu ◽  
Xiaojiang Wu ◽  
Lianhai Zhang ◽  
...  

2018 ◽  
Vol 26 (12) ◽  
pp. 1651-1657 ◽  
Author(s):  
T. McAlindon ◽  
M. Roberts ◽  
J. Driban ◽  
L. Schaefer ◽  
I.K. Haugen ◽  
...  

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9431-9436 ◽  
Author(s):  
Danni Li ◽  
Ye Zhang ◽  
Zhi Li ◽  
Ximing Wang ◽  
Xiujuan Qu ◽  
...  

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