Nanohybrid composed of graphene oxide functionalized with sodium hyaluronate accelerates bone healing in the tibia of rats

2021 ◽  
Vol 123 ◽  
pp. 111961
Author(s):  
Paulo César de Lacerda Dantas ◽  
Paulo Antônio Martins-Júnior ◽  
Danielle Carvalho Oliveira Coutinho ◽  
Vanessa Barbosa Andrade ◽  
Thalita Marcolan Valverde ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Healing ◽  
Sodium Hyaluronate

scholarly journals Enhancement of Rotator Cuff Tendon-bone Healing with Graphene Oxide/PRP Composite Scaffold in a Rabbit Model: A Histological and Biomechanical Study

2020 ◽  
Author(s):  
Bo Qin ◽  
Dingsu Bao ◽  
Shengqiang Zeng ◽  
Kai Deng ◽  
Gang Liu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Surgical Repair ◽  
Composite Scaffold ◽  
Rabbit Model ◽  
Control Groups ◽  
Significant Difference ◽  
Load To Failure ◽  
And Control

Abstract Background: Application of platelet-rich plasma (PRP) can improve tendon-bone healing (TBH) after rotator cuff surgical repair. Graphene Oxide (GO) is a steady, controlled, and sustained carrier. The purpose of this study is to determine whether GO/PRP Composite Scaffold enhances the TBH after RC surgical repair in a rabbit model.Methods: A full-thickness tear of the supraspinatus tendon was created and repaired in 36 adult male New Zealand rabbits. They were divided into three groups: Control group, PRP group, and GO/PRP Composite Scaffold group (GO group). The effect of GO/PRP Composite Scaffold on TBH was assessed using histological and biomechanical evaluations at 8 and 12 weeks postoperatively.Results: Histological analysis showed that greater continuity, better orientation, and more density of collagen fiber were detected in the GO group than PRP and Control groups at 8 and 12 weeks, respectively. Results of biomechanical evaluations showed that the load to failure and stiffness of the GO group were statistically higher than those of PRP and Control groups at both 8 and 12 weeks (P<0.05). Compared with 8 weeks in the GO group, there was no significant difference in load to failure at 12 weeks (P>0.05), while the stiffness at 12 weeks was higher than that at 8 weeks (P<0.05). Conclusions: These results demonstrated that GO/PRP Composite Scaffold enhanced the TBH following rotator cuff surgical repair in a rabbit model. The GO may be an effective carrier for PRP into repair sites.

Arabinoxylan/graphene‐oxide/nHAp‐NPs/PVA bio‐nano composite scaffolds for fractured bone healing

2021 ◽  
Author(s):  
Muhammad Umar Aslam Khan ◽  
Adnan Haider ◽  
Saiful Izwan Abd Razak ◽  
Mohammed Rafiq Abdul Kadir ◽  
Sajjad Haider ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Healing ◽  
Composite Scaffolds ◽  
Nano Composite

Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92804-92812 ◽  
Author(s):  
Fuxiang Song ◽  
Weibo Jie ◽  
Ting Zhang ◽  
Wen Li ◽  
Yanjiao Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Bone Healing ◽  
Room Temperature ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Promising Alternative ◽  
Reduced Graphene ◽  
Hydroxyapatite Composite

The development of tissue engineering (TE) provides a promising alternative strategy for bone healing and regeneration.

scholarly journals Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket

2016 ◽  
pp. 2265 ◽  
Author(s):  
Hirofumi Miyaji ◽  
Akihito Kato ◽  
Hiroko Takita ◽  
Toshihiko Iwanaga ◽  
Takehito Momose ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Healing ◽  
Proliferative Response ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Extraction Socket

scholarly journals Formation and Investigation of Physicochemical, Biological and Bacteriostatic Properties of Nanocomposite Foils Containing Silver Nanoparticles and Graphene Oxide in Hyaluronic Acid Matrix

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3377
Author(s):  
Karen Khachatryan ◽  
Lusine Khachatryan ◽  
Marcel Krzan ◽  
Magdalena Krystyjan ◽  
Lidia Krzemińska-Fiedorowicz ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Structural Changes ◽  
Fourier Transforms ◽  
Sodium Hyaluronate ◽  
Size Exclusion ◽  
Biomedical Sciences ◽  
Vis Spectroscopy ◽  
Wide Range

Natural polysaccharides, including hyaluronic acid, find a wide range of applications in biomedical sciences. There is a growing interest in nanocomposites containing hyaluronic acid and nanoparticles such as nanometals or graphene. In this study, we prepared foils of pure sodium hyaluronate and sodium hyaluronate containing nanosilver, graphene oxide, nanosilver/graphene oxide and characterized their properties. UV-vis spectroscopy and scanning electron microscopy (SEM) confirmed the formation of 10–20 nm silver nanoparticles. The structural changes were investigated using Fourier transforms infrared (FTIR) spectra and size exclusion chromatography. The obtained results suggest changes in molecular weights in the samples containing nanoparticles, which was highest in a sample containing nanosilver/graphene oxide. We also assessed the mechanical properties of the foils (thickness, tensile strength and elongation at break) and their wettability. The foils containing nanosilver and nanosilver/graphene oxide presented bacteriostatic activity against E. coli, Staphylococcus spp. and Bacillus spp., which was not observed in the control and sample containing graphene oxide. The composites containing graphene oxide and nanosilver/graphene oxide exhibited a cytotoxic effect on human melanoma WM266-4 cell lines (ATCC, Manassas, VA, USA).

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