An injectable adhesive antibacterial hydrogel wound dressing for infected skin wounds

2021 ◽  
pp. 112584
Author(s):  
Wendi Ma ◽  
Wenying Dong ◽  
Shanshan Zhao ◽  
Tianhui Du ◽  
Yilong Wang ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Skin Wounds ◽  
Infected Skin

scholarly journals Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1627 ◽  
Author(s):  
Thiago A.F. Ferro ◽  
Eliene B. Souza ◽  
Mariela A.M. Suarez ◽  
João F.S. Rodrigues ◽  
Domingos M.S. Pereira ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Topical Application ◽  
Transient Receptor Potential ◽  
Bacterial Load ◽  
Unmet Need ◽  
Antimicrobial Properties ◽  
Mouse Skin ◽  
Interleukin 17 ◽  
Skin Wounds ◽  
Infected Skin

Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the major component of cinnamon oil, is well known for its antimicrobial properties. Herein, we investigated the effects of sub-inhibitory concentrations of cinnamaldehyde in the virulence of P. aeruginosa. We also assessed its healing potential in P. aeruginosa-infected mouse skin wounds and the mechanisms involved in this response. Sub-inhibitory concentrations of cinnamaldehyde reduced P. aeruginosa metabolic rate and its ability to form biofilm and to cause haemolysis. Daily topical application of cinnamaldehyde on P. aeruginosa-infected skin wounds reduced tissue bacterial load and promoted faster healing. Lower interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and nitric oxide levels were detected in cinnamaldehyde-treated wound samples. Blockage of transient receptor potential ankyrin 1, the pharmacological target of cinnamaldehyde, abrogated its healing activity and partially reversed the inhibitory actions of this compound on VEGF and IL-17 generation. We suggest that topical application of sub-inhibitory concentrations of cinnamaldehyde may represent an interesting approach to improve the healing of P. aeruginosa-infected skin wounds.

scholarly journals The bactericidal effect of lysostaphin coupled with liposomal vancomycin as a dual combating system applied directly on methicillin-resistant Staphylococcus aureus infected skin wounds in mice 

2019 ◽  
Vol Volume 14 ◽  
pp. 5943-5955 ◽  
Author(s):  
Fahimeh Hajiahmadi ◽  
Mohammad Yousef Alikhani ◽  
Hanifeh Shariatifar ◽  
Mohammad Reza Arabestani ◽  
Davoud Ahmadvand
Keyword(s):  
Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Skin Wounds ◽  
Methicillin Resistant ◽  
Infected Skin

In-depth characterization of antibacterial activity of melittin against Staphylococcus aureus and use in a model of non-surgical MRSA-infected skin wounds

2021 ◽  
Vol 156 ◽  
pp. 105592
Author(s):  
William Gustavo Lima ◽  
Júlio César Moreira de Brito ◽  
Valbert Nascimento Cardoso ◽  
Simone Odília Antunes Fernandes
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Skin Wounds ◽  
Infected Skin

Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes Acinetobacter baumannii-infected skin wounds in mice

Amino Acids ◽  
2015 ◽  
Vol 48 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Istvan Sebe ◽  
Eszter Ostorhazi ◽  
Aron Fekete ◽  
Krisztian N. Kovacs ◽  
Romana Zelko ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Antimicrobial Peptide ◽  
Acinetobacter Baumannii ◽  
Skin Wounds ◽  
Infected Skin

Clinical efficacy of biocellulose, carboxymethyl cellulose and normal saline dressing in epidermolysis bullosa

2019 ◽  
Vol 28 (Sup10) ◽  
pp. S4-S9 ◽  
Author(s):  
Reiva Farah Dwiyana ◽  
Yuri Yogya ◽  
Srie Prihianti Gondokaryono ◽  
Inne Arline Diana ◽  
Oki Suwarsa ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Normal Saline ◽  
Carboxymethyl Cellulose ◽  
Wound Dressing ◽  
Care Management ◽  
Wound Care ◽  
Skin Wounds ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Objective: To evaluate the efficacy of a biocellulose, a carboxymethyl cellulose and a normal saline wound dressing in the wound care management of epidermolysis bullosa (EB) skin wounds. Methods: This was a single-blind, randomised controlled trial involving wounds from patients with EB. Wounds were divided into three groups: group I with biocellulose wound dressing, group II with carboxymethyl cellulose wound dressing and group III with normal saline wound dressing as a control. All dressing changes and wound parameters were recorded. Observations were conducted every three days until complete wound closure or up to one month. Results: The outcomes of treatment of 36 wounds from four patients were evaluated in this study. Mean healing time in group I was seven days, eight days in group II and 14 days in group III. There were significant differences in healing times between group I and group III (p=0.0001) and between group II and III (p=0.001). The results showed a significant reduction in the percentage of wounds area on day three for each group: 51.7% in group I, 51.9% in group II, and 26% for group III. All wounds in groups I and II had healed at day 12 (100%) and at day 24 (100%) in group III. There were significant differences in the reduction of percentage wound area between group I and group III at day three (p=0.044) and day six (p=0.000), and between group II and III at day six (p=0.003). Conclusion: The study demonstrates that both the biocellulose and the carboxymethyl cellulose wound dressings significantly reduced percentage wound areas and complete healing times compared with the normal saline wound dressing in EB skin wounds, demonstrating they are both equally good for wound care management in EB patients.

scholarly journals The new formulation of the 0,05% sodium hypochlorite electrolytic solution for cutaneous use: reasons and advantages

ABOUTOPEN ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 14-22
Author(s):  
Alessandro Scalise
Keyword(s):  
Sodium Hypochlorite ◽  
Positive Impact ◽  
Skin Lesions ◽  
Skin Wounds ◽  
Electrolytic Solution ◽  
First Choice ◽  
Wide Range ◽  
New Formulation ◽  
Infected Skin

Superinfection of skin lesions is quite common, and often delays wound recovery. Infection control plays therefore a key role in the management of skin lesions, requiring the use of specific antimicrobials. Among available agents, topic antiseptic drugs are currently recommended as a first-choice option, to be preferred to antibiotics, given the growing resistance to these drugs. Compared to antibiotics, antiseptic drugs have a wider spectrum of action, including bacteria, fungi, virus, protozoa, and prions. The ideal antiseptic for the management of an infected skin lesion is expected to be both highly effective and well tolerated, in order to promote the physiologic process of tissue restoration. Among available antiseptics, the 0,05% sodium hypochlorite electrolytic solution meets these criteria: the product proved to be effective in vitro and in animal experimental models against a wide range of microorganisms, besides exerting an anti-inflammatory action in the absence of any irritating, cytotoxic or carcinogenic adverse effect, and being useful in biofilm removal. Similarly, in several clinical trials, the 0,05% sodium hypochlorite electrolytic solution was demonstrated to be very effective and safe in the management of infected skin wounds: based on these results, this product should be strongly considered among the first-choice options for the disinfection of skin wounds. The new formulation, developed according to the latest reference standards for wound healing and in agreement with current guidelines, is qualitatively improved, with an expected positive impact in every field of clinical application and a subsequent benefit for treated patients.

Bilayer Cryogel Wound Dressing and Skin Regeneration Grafts for the Treatment of Acute Skin Wounds

2016 ◽  
Vol 8 (24) ◽  
pp. 15145-15159 ◽  
Author(s):  
S. Geetha Priya ◽  
Ankur Gupta ◽  
Era Jain ◽  
Joyita Sarkar ◽  
Apeksha Damania ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Skin Regeneration ◽  
Skin Wounds
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