scholarly journals Extreme reduction of the capillary lumen in segments of the venular legs of human cutaneous capillaries

2009 ◽  
Vol 78 (2) ◽  
pp. 241-245 ◽  
Author(s):  
F. Jung ◽  
R.P. Franke
Keyword(s):  
Capillary Lumen

Lung tissue volume changes induced by hypertonic NaCl: morphometric evaluation

1981 ◽  
Vol 51 (6) ◽  
pp. 1443-1450 ◽  
Author(s):  
D. Wangensteen ◽  
H. Bachofen ◽  
E. R. Weibel
Keyword(s):  
Lung Tissue ◽  
Alveolar Epithelium ◽  
Cell Types ◽  
Ringer Solution ◽  
Capillary Endothelium ◽  
Vascular Perfusion ◽  
Tissue Samples ◽  
Membrane Area ◽  
Capillary Lumen ◽  
Osmotic Effect

Lung tissue was examined to determine how the volumes of alveolar septum components change when NaCl is added to the vascular perfusate, increasing the osmolarity by 70 mosM. Isolated rabbit lungs were perfused with Ringer solution containing dextran, either with or without added NaCl, and fixed by vascular perfusion. Tissue samples from both “control” and “hypertonic” lungs, prepared for electron microscopy, were examined using established morphometric procedures. Volumes of septal cells, interstitial space, capillary lumen, surface-lining layer, and endothelial and epithelial areas were measured, all normalized against the endothelium basement-membrane area. Results showed that hypertonic NaCl caused a reduction in total cell and surface-lining layer volumes but no change in interstitial or capillary lumen volumes. This supports the hypothesis that small molecules have no osmotic effect across the pulmonary capillary endothelium but do cause a fluid flux from cells and across the alveolar epithelium. Areas and volume measurements for different septal cell types suggest a heterogeneous response: epithelial cells showed significant decreases and endothelial cells changed little, if at all.

scholarly journals STUDIES ON THE GENERALIZED SHWARTZMAN REACTION

1958 ◽  
Vol 107 (3) ◽  
pp. 333-340 ◽  
Author(s):  
George D. Pappas ◽  
Michael H. Ross ◽  
Lewis Thomas
Keyword(s):  
Escherichia Coli ◽  
Endothelial Cells ◽  
Single Dose ◽  
Lamina Densa ◽  
Capillary Lumen ◽  
Intravenous Injections ◽  
Lipopolysaccharide Endotoxin ◽  
Shwartzman Reaction ◽  
Escherichia Coli Lipopolysaccharide ◽  
Glomerular Capillaries

The intravascular fibrinoid which is deposited in glomerular capillaries of the rabbit during the generalized Shwartzman reaction has been studied with the aid of the electron microscope. In one group of animals the reaction was produced by two intravenous injections of Escherichia coli lipopolysaccharide endotoxin, spaced 24 hours apart. In another, a single dose of endotoxin was followed, 1 hour later, by intravenous liquoid (sodium polyanethol sulfonate). The appearance of fibrinoid was the same in the two groups. Initially, fibrinoid deposition occurred on the irregular, swollen surfaces of the endothelial cells within the capillary lumen. Subsequently, the fibrinoid mass increased to such proportions that the capillary lumen was completely occluded. Fibrinoid was found to be composed of unbranched fibrils, having a diameter of 200–300 angstroms and an axial repeating structure of 120 A. The basement membrane (lamina densa) underwent no change in appearance during the time when fibrinoid was being laid down. Balloon-like vesicles were consistently encountered in endothelial cells of glomerular capillaries after two doses of endotoxin, and also in animals given one injection of endotoxin followed by liquoid. The possible significance of the observations are discussed. It is suggested that they are compatible with the hypothesis, proposed earlier, that intravascular fibrinoid, in the generalized Shwartzman reaction, is derived from fibrinogen.

scholarly journals Hepatozoon-Like Parasite (Schizonts) in the Myocardium of the Domestic Cat

1973 ◽  
Vol 10 (3) ◽  
pp. 185-190 ◽  
Author(s):  
U. Klopfer ◽  
T. A. Nobel ◽  
F. Neumann
Keyword(s):  
Lymph Nodes ◽  
Peripheral Blood ◽  
Domestic Cat ◽  
The Other ◽  
Capillary Lumen ◽  
Spleen And Lymph Nodes

In a survey of 100 necropsies on cats, 36 were found to have Hepatozoom sp. schizonts in the myocardium. The schizonts appeared lo he located in the capillary lumen. Two forms of schizonts were seen, one containing peripheral rosettes of merozoite-like formations and the other filled with them, showing a cyst-like structure. No parasites were seen in the peripheral blood, spleen, and lymph nodes.

scholarly journals Rouget cells and their function

1926 ◽  
Vol 100 (700) ◽  
pp. 23-31 ◽  
Keyword(s):  
Blood Capillaries ◽  
Capillary Lumen ◽  
Wide Acceptance ◽  
Mammalian Skin ◽  
Adventitial Cells

Of recent years, owing to the work of Krogh and his collaborators, the idea that the contractility of blood capillaries resides in certain adventitial cells has been brought into prominence and has gained a wide acceptance. Vimtrup (5, 6, 7) succeeded in displaying, by histological methods, cells applied to the walls of capillaries. He stated that these cells were contractile, and that, by the shortening of their elongated processes, the capillary lumen was narrowed. These results were obtained, for the most part, in the frog, although analogous cells were described as existing on the capillaries of the mammalian skin.

Alterations in glomerular permeability in streptozotocin-induced diabetic rats

1996 ◽  
Vol 86 (2) ◽  
pp. 57-62 ◽  
Author(s):  
RB Boyd ◽  
VW Thompson ◽  
J Atkin
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Diabetic Rats ◽  
Capillary Wall ◽  
Diabetic Rat ◽  
Electron Microscopic ◽  
Glomerular Permeability ◽  
Glomerular Capillary Wall ◽  
Capillary Lumen ◽  
Glomerular Capillary

The alteration in glomerular basement membrane permeability associated with microangiopathy in streptozotocin-induced diabetic rats was studied by determining the movement across the glomerular basement membrane of anionic ferritin probes injected into rats at different points in the development of the disease. Visualization of the concentration gradient of anionic ferritin and changes in ultrastructure was accomplished by electron microscopic examination of renal tissue prepared from both control and diabetic rats. In all control rats, the anionic ferritin did not leave the glomerular capillary lumen, nor were there any changes in the normal morphology of the glomerular capillary wall. In the diabetic animals, the concentration of anionic ferritin shifted from the capillary lumen in the abluminal direction. Distinct morphologic changes, such as widening of endothelial intercellular junctions, focal detachment of podocyte foot processes, and extensive thickening of the glomerular basement membrane, were noted in the diabetic rat, and these changes appear to correlate with the observed increase in permselectivity of anionic ferritin across the glomerular capillary wall.

scholarly journals GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Xuchen Hu ◽  
Ken Matsumoto ◽  
Rachel S Jung ◽  
Thomas A Weston ◽  
Patrick J Heizer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoprotein Lipase ◽  
Glioma Cells ◽  
Human Gliomas ◽  
Peripheral Tissues ◽  
Capillary Lumen ◽  
Capillary Endothelial Cells ◽  
Parenchymal Cells ◽  
The Brain

GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1–LPL complex is crucial for the generation of lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent from the capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in the capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We use NanoSIMS imaging to show that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells.

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