Effects of External Low Intensity Focused Ultrasound on Inflammatory Markers in Neuropathic Pain

2021 ◽  
pp. 135977
Author(s):  
Abigail Hellman ◽  
Alicia Clum ◽  
Teresa Maietta ◽  
Adithya Srikanthan ◽  
Vraj Patel ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Inflammatory Markers ◽  
Focused Ultrasound ◽  
Low Intensity

Preliminary effects of low-intensity focused ultrasound treatment program for cancer-related neuropathic pain

2021 ◽  
Author(s):  
Ankur A Patel ◽  
Max Zhukosvky ◽  
Shawn Sidharthan ◽  
Rohan Jotwani ◽  
Neal Rakesh ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Focused Ultrasound ◽  
Rating Scale ◽  
Pulse Mode ◽  
Side Effect Profile ◽  
Low Intensity ◽  
Numeric Pain Rating Scale ◽  
Pain Rating Scale ◽  
Viable Treatment

Aim: To evaluate the effectiveness of low-intensity focused ultrasound (LIFU) therapy in the management of cancer-related neuropathic pain (CNP). Methods: A retrospective review with 22 patients with CNP treated with LIFU therapy (frequency 3 Hz, 3 W/cm2, pulse mode duty cycle 50%) was conducted. Results: Out of the 22 patients, 15 had CNP secondary to chemotherapy-induced peripheral neuropathy. Compared with baseline, there was a significant reduction in numeric pain rating scale (p < 0.001). Additionally, 76.5% of patients (n = 13) were considered to be responders to LIFU therapy. Conclusion: LIFU therapy may be a viable treatment modality in the management of CNP, specifically chemotherapy-induced peripheral neuropathy, with a minimal side effect profile. Larger, prospective studies with a structured protocol are necessary.

Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain

2021 ◽  
pp. 1-8
Author(s):  
Abigail Hellman ◽  
Teresa Maietta ◽  
Alicia Clum ◽  
Kanakaharini Byraju ◽  
Nataly Raviv ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Peroneal Nerve ◽  
Focused Ultrasound ◽  
Treatment Algorithm ◽  
Common Peroneal Nerve ◽  
Tissue Temperature ◽  
Large Animal Model ◽  
Swine Model ◽  
Large Animal ◽  
Low Intensity

OBJECTIVE The authors’ laboratory has previously demonstrated beneficial effects of noninvasive low intensity focused ultrasound (liFUS), targeted at the dorsal root ganglion (DRG), for reducing allodynia in rodent neuropathic pain models. However, in rats the DRG is 5 mm below the skin when approached laterally, while in humans the DRG is typically 5–8 cm deep. Here, using a modified liFUS probe, the authors demonstrated the feasibility of using external liFUS for modulation of antinociceptive responses in neuropathic swine. METHODS Two cohorts of swine underwent a common peroneal nerve injury (CPNI) to induce neuropathic pain. In the first cohort, pigs (14 kg) were iteratively tested to determine treatment parameters. liFUS penetration to the L5 DRG was verified by using a thermocouple to monitor tissue temperature changes and by measuring nerve conduction velocity (NCV) at the corresponding common peroneal nerve (CPN). Pain behaviors were monitored before and after treatment. DRG was evaluated for tissue damage postmortem. Based on data from the first cohort, a treatment algorithm was developed, parameter predictions were verified, and neuropathic pain was significantly modified in a second cohort of larger swine (20 kg). RESULTS The authors performed a dose-response curve analysis in 14-kg CPNI swine. Specifically, after confirming that the liFUS probe could reach 5 cm in ex vivo tissue experiments, the authors tested liFUS in 14-kg CPNI swine. The mean ± SEM DRG depth was 3.79 ± 0.09 cm in this initial cohort. The parameters were determined and then extrapolated to larger animals (20 kg), and predictions were verified. Tissue temperature elevations at the treatment site did not exceed 2°C, and the expected increases in the CPN NCV were observed. liFUS treatment eliminated pain guarding in all animals for the duration of follow-up (up to 1 month) and improved allodynia for 5 days postprocedure. No evidence of histological damage was seen using Fluoro-Jade and H&E staining. CONCLUSIONS The results demonstrate that a 5-cm depth can be reached with external liFUS and alters pain behavior and allodynia in a large-animal model of neuropathic pain.

scholarly journals Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

2018 ◽  
Vol 128 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Robert F. Dallapiazza ◽  
Kelsie F. Timbie ◽  
Stephen Holmberg ◽  
Jeremy Gatesman ◽  
M. Beatriz Lopes ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Thalamic Nucleus ◽  
Acoustic Energy ◽  
Similar Degree ◽  
Thalamic Nuclei ◽  
Low Intensity ◽  
Tissue Heating ◽  
The Central Nervous System ◽  
Selective Mapping ◽  
Noninvasive Neuromodulation

OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal.METHODSTen Yorkshire swine (Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage.RESULTSLIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage.CONCLUSIONSThese results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

Quantification of Displacement for Tactile Sensation in a Contact-type Low Intensity Focused Ultrasound Haptic Device

2020 ◽  
Vol 18 (1) ◽  
pp. 1-8
Author(s):  
Jeongbong Choi ◽  
Soonhyun Yook ◽  
In Young Kim ◽  
Mok Kun Jeong ◽  
Dong Pyo Jang
Keyword(s):  
Focused Ultrasound ◽  
Haptic Device ◽  
Tactile Sensation ◽  
Contact Type ◽  
Low Intensity

Modulating the Inflammatory Reflex in Rats Using Low-Intensity Focused Ultrasound Stimulation of the Vagus Nerve

2019 ◽  
Vol 45 (2) ◽  
pp. 481-489 ◽  
Author(s):  
Kelsey M. Wasilczuk ◽  
Kelsey C. Bayer ◽  
Jesse P. Somann ◽  
Gabriel O. Albors ◽  
Jennifer Sturgis ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Stimulation Of

In vivo MRI visualization of release from liposomes triggered by local application of pulsed low-intensity non-focused ultrasound

2014 ◽  
Vol 10 (5) ◽  
pp. e901-e904 ◽  
Author(s):  
Silvia Rizzitelli ◽  
Pierangela Giustetto ◽  
Cinzia Boffa ◽  
Daniela Delli Castelli ◽  
Juan Carlos Cutrin ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Local Application ◽  
Low Intensity

scholarly journals Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyun-Chul Kim ◽  
Wonhye Lee ◽  
Jennifer Kunes ◽  
Kyungho Yoon ◽  
Ji Eun Lee ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Brain Activity ◽  
Response Rates ◽  
Behavioral Observation ◽  
Acoustic Stimulation ◽  
Motion Artifacts ◽  
Experimental Conditions ◽  
Low Intensity ◽  
Hind Limbs ◽  
Brain Tissue Damage

AbstractTranscranial application of pulsed low-intensity focused ultrasound (FUS) modulates the excitability of region-specific brain areas, and anesthetic confounders on brain activity warrant the evaluation of the technique in awake animals. We examined the neuromodulatory effects of FUS in unanesthetized sheep by developing a custom-fit headgear capable of reproducibly placing an acoustic focus on the unilateral motor cortex (M1) and corresponding thalamic area. The efferent responses to sonication, based on the acoustic parameters previously identified in anesthetized sheep, were measured using electromyography (EMG) from both hind limbs across three experimental conditions: on-target sonication, off-target sonication, and without sonication. Excitatory sonication yielded greater amplitude of EMG signals obtained from the hind limb contralateral to sonication than that from the ipsilateral limb. Spurious appearance of motion-related EMG signals limited the amount of analyzed data (~ 10% selection of acquired data) during excitatory sonication, and the averaged EMG response rates elicited by the M1 and thalamic stimulations were 7.5 ± 1.4% and 6.7 ± 1.5%, respectively. Suppressive sonication, while sheep walked on the treadmill, temporarily reduced the EMG amplitude from the limb contralateral to sonication. No significant change was found in the EMG amplitudes during the off-target sonication. Behavioral observation throughout the study and histological analysis showed no sign of brain tissue damage caused by the acoustic stimulation. Marginal response rates observed during excitatory sonication call for technical refinement to reduce motion artifacts during EMG acquisitions as well as acoustic aberration correction schemes to improve spatial accuracy of sonication. Yet, our results indicate that low-intensity FUS modulated the excitability of regional brain tissues reversibly and safely in awake sheep, supporting its potential in theragnostic applications.

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