scholarly journals Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

NeuroImage ◽  
2020 ◽  
Vol 220 ◽  
pp. 117105
Author(s):  
Kathrine Skak Madsen ◽  
Louise Baruël Johansen ◽  
Wesley K. Thompson ◽  
Hartwig R. Siebner ◽  
Terry L. Jernigan ◽  
...  
Keyword(s):  
White Matter ◽  
Children And Adolescents ◽  
Motor Response ◽  
Motor Area ◽  
White Matter Microstructure ◽  
The Right

scholarly journals Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

2020 ◽  
Author(s):  
Kathrine Skak Madsen ◽  
Louise Baruël Johansen ◽  
Wesley K. Thompson ◽  
Hartwig R. Siebner ◽  
Terry L. Jernigan ◽  
...  
Keyword(s):  
White Matter ◽  
Children And Adolescents ◽  
Fractional Anisotropy ◽  
Motor Response ◽  
Stop Signal ◽  
Motor Area ◽  
Stop Signal Task ◽  
List Type ◽  
White Matter Microstructure ◽  
The Right

AbstractThe ability to effectively suppress motor response tendencies is essential for focused and goal-directed behavior. Here, we tested the hypothesis that developmental improvement in the ability to cancel a motor response is reflected by maturational changes in the white matter underlying the right presupplementary motor area (preSMA) and posterior inferior frontal gyrus (IFG), two cortical key areas of the fronto-basal ganglia “stopping” network. Eighty-eight typically-developing children and adolescents, aged 7-19 years, were longitudinally assessed with the stop-signal task (SST) and diffusion tensor imaging (DTI) of the brain over a period of six years. Participants were examined from two to nine times with an average of 6.6 times, resulting in 576 SST-DTI datasets. We applied tract-based spatial statistics to extract mean fractional anisotropy (FA) from regions-of-interest in the white matter underlying the right IFG (IFGFA) and right preSMA (preSMAFA) at each time point. Motor response cancelation performance, estimated with the stop-signal reaction time (SSRT), improved with age. Initially well performing children plateaued around the age of 11 years, while initially poor performers caught up at the age of 13-14 years. White matter microstructure continued to mature across the investigated age range. Males generally displayed linear maturational trajectories, while females displayed more curvilinear trajectories that leveled off around 12-14 years of age. Maturational increases in right preSMAFA but not right IFGFA were associated with developmental improvements in SSRT. This association differed depending on the mean right preSMAFA across the individual maturational trajectory. Children with lower mean right preSMAFA exhibited poorer SSRT performance at younger ages but steeper developmental trajectories of SSRT improvement. Children with higher mean right preSMAFA exhibited flatter trajectories of SSRT improvement along with faster SSRT already at the first assessments. The results suggest that no further improvement in motor response cancellation is achieved once a certain level of maturity in the white matter underlying the right preSMA is reached. Similar dynamics may apply to other behavioral read-outs and brain structures and, thus, need to be considered in longitudinal MRI studies designed to map brain structural correlates of behavioral changes during development.HighlightsMotor response cancellation, i.e. SSRT, improvement plateaued at 13-14 years of ageFractional anisotropy (FA) captured maturation of white matter (WM) microstructureFA in the WM underlying right preSMA (preSMAFA) reflected SSRT improvement with ageIndividual SSRT improvement depended on mean right preSMAFA across all DTI sessionsChildren with lower mean right preSMAFA had the steepest improvements in SSRT

scholarly journals Consistent altered internal capsule white matter microstructure in insomnia disorder

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Tom Bresser ◽  
Jessica C Foster-Dingley ◽  
Rick Wassing ◽  
Jeanne Leerssen ◽  
Jennifer R Ramautar ◽  
...  
Keyword(s):  
White Matter ◽  
Internal Capsule ◽  
Mixed Effect ◽  
Significant Group ◽  
Consistent Finding ◽  
White Matter Microstructure ◽  
Insomnia Disorder ◽  
Underlying Mechanisms ◽  
The Right ◽  
Insomnia Severity

Abstract Study Objectives Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls. Methods 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case–control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity. Results FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (β = −9.76e−3; SE = 4.17e−3, p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (β = −8.05e− 4 FA/ISI point, SE = 2.60e− 4, p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons. Conclusions The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia.

scholarly journals Microstructural anatomical differences between bilinguals and monolinguals

2017 ◽  
Vol 21 (5) ◽  
pp. 995-1008 ◽  
Author(s):  
NANDINI C. SINGH ◽  
ARCHITH RAJAN ◽  
ARCHANA MALAGI ◽  
KEERTHI RAMANUJAN ◽  
MATTEO CANINI ◽  
...  
Keyword(s):  
White Matter ◽  
Mean Diffusivity ◽  
English Speakers ◽  
Cerebral White Matter ◽  
Language Experience ◽  
Bilingual Speakers ◽  
White Matter Microstructure ◽  
Inferior Longitudinal Fasciculus ◽  
The Right ◽  
Anterior Thalamic Radiation

DTI is an established method to study cerebral white-matter microstructure. Two established measures of DTI are fractional anisotropy (FA) and mean diffusivity (MD) and both differ for bilingual and monolingual speakers. Less is known about differences in two other measures called radial (RD) and axial diffusivity (AD). We report differences in mean RD and AD-values in the right superior longitudinal fasciculus (SLF) and forceps minor between bilingual (Hindi–English) and monolingual (English) speakers as well as differences in mean FA-values in the anterior thalamic radiation, right inferior fronto-occipital and inferior longitudinal fasciculus (ILF) and mean MD-values in forceps minor and bilateral SLF. Noteworthy, a positive correlation between L2 proficiency and mean RD-values in the right SLF was observed. We suggest that changes in the geometry of white matter tracts reflect regular bilingual language experience and contend that neuroplasticity in right SLF results from demands on cognitive control for bilingual speakers.

The possible mechanisms of electromagnetic phone effects on the auditory system of children and adolescents

2021 ◽  
Author(s):  
N.I. Khorseva ◽  
P.E. Grigoriev
Keyword(s):  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Children And Adolescents ◽  
Auditory System ◽  
Motor Response ◽  
Pearson Correlation ◽  
Motor Reaction ◽  
The Right ◽  
Contralateral Effects ◽  
Daily Time

For the first time, we compared the gradients of changes in the simple auditory-motor response (SAMR) and the daily time of using a mobile phone (MP), which made it possible to describe the variants of possible changes in lateralization of effects and the frequency of their occurrence for different variants of SAMR changes. This study has no analogues neither in Russian nor in foreign publications and is currently exclusive. Objective – to determine the patterns of manifestation of contra- and ipsilateral effects, using individual changes in indicators of a simple auditory-motor response obtained as a result of longitudinal observations. The analysis of changes in the parameters of a simple auditory-motor reaction was carried out during mono-presentation of a sound signal on the left and on the right in 145 children and adolescents aged 7-14 years (470 measurements), who were under observation for 2 or more years, depending on changes in the mode of use mobile phone. Further, 48 cases were excluded (change in the lateralization of use, for example, the respondent brought the phone to both the right and the left ear, “changed” the leading ear, etc.). Three variants of changes in the mode of using MP in the longitude period (gradient of time change) were established: an increase in time (the group "less–more"), a decrease in time (group "more–less") and no changes. For each group, 4 variants of changes in the parameters of SAMR were revealed in the dynamics of observations along the longitude: decrease in SAMR indicators on the left (left ear) and increase in the right (right ear); decrease in indicators on the left and increase on the right and synchronous decrease or increase in indicators on the right and left. An assessment of the strength of the correlation was carried out (a linear Pearson correlation coefficient was used and an assessment of the statistical significance was carried out): between changes in the gradient of changes in the time of MP usage and SAMR, as well as changes in the lateralization of effects (changes in the frequency of occurrence of ipsi- and contralateral effects). The multivariance of changes in SAMR indicators and lateralization of effects was revealed depending on the mode of MP use. The proposed approach to the analysis of changes in a simple auditory-motor reaction and daily time of using a mobile phone makes it possible to suggest some mechanisms of changes in the parameters of the auditory analyzer in response to the duration of exposure to electromagnetic radiation from a mobile phone. The presence of contralateral effects of changes in SAMR parameters can serve as an assessment of the “capture” of the brain structures of children and adolescents by MP electromagnetic radiation. The results obtained once again prove the level of negative impact on the auditory system of children and adolescents. The current situation requires an immediate solution by clear regulation of the use of cellular communications by the younger generation.

scholarly journals Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study

2014 ◽  
Vol 120 (4) ◽  
pp. 882-890 ◽  
Author(s):  
Takeshi Sasaki ◽  
Ofer Pasternak ◽  
Michael Mayinger ◽  
Marc Muehlmann ◽  
Peter Savadjiev ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Ice Hockey ◽  
Cognitive Test ◽  
Corona Radiata ◽  
White Matter Microstructure ◽  
Hockey Players ◽  
History Of ◽  
The Right

Object The aim of this study was to examine the brain's white matter microstructure by using MR diffusion tensor imaging (DTI) in ice hockey players with a history of clinically symptomatic concussion compared with players without a history of concussion. Methods Sixteen players with a history of concussion (concussed group; mean age 21.7 ± 1.5 years; 6 female) and 18 players without a history of concussion (nonconcussed group; mean age 21.3 ± 1.8 years, 10 female) underwent 3-T DTI at the end of the 2011–2012 Canadian Interuniversity Sports ice hockey season. Tract-based spatial statistics (TBSS) was used to test for group differences in fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and the measure “trace,” or mean diffusivity. Cognitive evaluation was performed using the Immediate Postconcussion Assessment and Cognitive Test (ImPACT) and the Sport Concussion Assessment Tool–2 (SCAT2). Results TBSS revealed a significant increase in FA and AD, and a significant decrease in RD and trace in several brain regions in the concussed group, compared with the nonconcussed group (p < 0.05). The regions with increased FA and decreased RD and trace included the right posterior limb of the internal capsule, the right corona radiata, and the right temporal lobe. Increased AD was observed in a small area in the left corona radiata. The DTI measures correlated with neither the ImPACT nor the SCAT2 scores. Conclusions The results of the current study indicate that a history of concussion may result in alterations of the brain's white matter microstructure in ice hockey players. Increased FA based on decreased RD may reflect neuroinflammatory or neuroplastic processes of the brain responding to brain trauma. Future studies are needed that include a longitudinal analysis of the brain's structure and function following a concussion to elucidate further the complex time course of DTI changes and their clinical meaning.

scholarly journals White matter abnormalities in adults with bipolar disorder type-II and unipolar depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna Manelis ◽  
Adriane Soehner ◽  
Yaroslav O. Halchenko ◽  
Skye Satz ◽  
Rachel Ragozzino ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Anterior Part ◽  
Mean Diffusivity ◽  
Unipolar Depression ◽  
Type Ii ◽  
White Matter Abnormalities ◽  
White Matter Microstructure ◽  
The Right ◽  
Disorder Type

AbstractDiscerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthreshold hypomanic symptoms such as elevated mood, irritability, and increased activity. Previous studies linked bipolar disorder to widespread white matter abnormalities. However, no published work has compared white matter microstructure in individuals with BD-II vs. UD vs. healthy controls (HC), or examined the relationship between spectrum (dimensional) measures of hypomania and white matter microstructure across those individuals. This study aimed to examine fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) across BD-II, UD, and HC groups in the white matter tracts identified by the XTRACT tool in FSL. Individuals with BD-II (n = 18), UD (n = 23), and HC (n = 24) underwent Diffusion Weighted Imaging. The categorical approach revealed decreased FA and increased RD in BD-II and UD vs. HC across multiple tracts. While BD-II had significantly lower FA and higher RD values than UD in the anterior part of the left arcuate fasciculus, UD had significantly lower FA and higher RD values than BD-II in the area of intersections between the right arcuate, inferior fronto-occipital and uncinate fasciculi and forceps minor. The dimensional approach revealed the depression-by-spectrum mania interaction effect on the FA, RD, and AD values in the area of intersection between the right posterior arcuate and middle longitudinal fasciculi. We propose that the white matter microstructure in these tracts reflects a unique pathophysiologic signature and compensatory mechanisms distinguishing BD-II from UD.

scholarly journals Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression

2019 ◽  
Vol 23 (1) ◽  
pp. 20-25
Author(s):  
Gregor Gryglewski ◽  
René Seiger ◽  
Pia Baldinger-Melich ◽  
Jakob Unterholzner ◽  
Benjamin Spurny ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Electroconvulsive Therapy ◽  
Electrode Placement ◽  
Treatment Resistant Depression ◽  
Resonance Imaging ◽  
Treatment Resistant ◽  
White Matter Microstructure ◽  
Resistant Depression ◽  
The Right

Abstract Background Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation. Methods A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeated-measures ANOVA. Results A total 12 patients responded to electroconvulsive therapy and 9 were classified as remitters. An increase in axial diffusivity was observed in the posterior limb of the internal capsule of the right hemisphere (PFWE ≤ .05). The increase in this area was higher in the right compared with the left hemisphere (P &lt; .05). No correlation of this effect with treatment response could be found. Conclusions The strong lateralization of effects to the hemisphere of electrical stimulation suggests an effect of electroconvulsive therapy on diffusivity metrics which is dependent of electrode placement. Investigation in controlled studies is necessary to reveal to what extent the effects of electroconvulsive therapy on white matter microstructure are related to clinical outcomes and electrode placement.

scholarly journals A Reproducible Neurobiology of Depressive Rumination

2018 ◽  
Author(s):  
D.A. Pisner ◽  
J. Shumake ◽  
C.G. Beevers ◽  
D.M. Schnyer
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Executive Control ◽  
Structural Basis ◽  
Functional Magnetic Resonance ◽  
Resting State Functional Connectivity ◽  
Control Networks ◽  
Depressive Rumination ◽  
White Matter Microstructure ◽  
The Right

AbstractDepressive Rumination (DR), which involves a repetitive focus on one’s distress, has been linked to alterations in functional connectivity of the ‘triple-network’, consisting of Default-Mode, Salience, and Executive Control networks. A structural basis for these functional alterations that can dually explain DR’s persistence as a stable trait remains unexplored, however. Using diffusion and functional Magnetic Resonance Imaging, we investigated multimodal relationships between DR severity, white-matter microstructure, and resting-state functional connectivity in depressed adults, and then directly replicated our results in a phenotypically-matched, independent sample (total N = 78). Among the fully-replicated findings, DR severity was associated with: (a) global microstructure of the right Superior Longitudinal Fasciculus and local microstructure of distributed primary-fiber and crossing-fiber white-matter; (b) an imbalance of functional connectivity segregation and integration of the triple-network; and (c) ‘multi-layer’ associations linking these microstructural and functional connectivity biomarkers to one another. Taken together, the results provide reproducible evidence for a multi-layer, microstructural-functional network model of rumination in the depressed brain.

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