scholarly journals DISMINUCIÓN DE LAS DISCINESIAS EN UN MODELO DE PARKINSON EN RATAS WISTAR, MEDIADA POR EL FITOFARMACO Mucuna pruriens

2021 ◽  
Author(s):  
Julian camilo Guzman ◽  
Cristian Alexander Otalora ◽  
Paola Caro ◽  
Erika Lucia Mayorga ◽  
Jessica Paola Alcazar ◽  
...  
Keyword(s):  
Mucuna Pruriens

Mucuna pruriens (Kewanch), the L-DOPA (anti parkinson's drug) producing plant species: current scenario and future prospects

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
SS Dhawan ◽  
SK Susheel ◽  
MP Darokar ◽  
H Mishra ◽  
RK Lal
Keyword(s):  
Plant Species ◽  
Mucuna Pruriens ◽  
Future Prospects ◽  
Current Scenario

Antiulcer and Antioxidant Activity of a Lectin from Mucuna pruriens Seeds on Ethanol- induced Gastropathy: Involvement of Alpha-2 Adrenoceptors and Prostaglandins

2019 ◽  
Vol 25 (12) ◽  
pp. 1430-1439 ◽  
Author(s):  
Isabela Ribeiro Pinto ◽  
Hellíada V. Chaves ◽  
Auriana S. Vasconcelos ◽  
Francisca Clea F de Sousa ◽  
Tatiane Santi-Gadelha ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Acute Toxicity ◽  
Antioxidant Activities ◽  
Mucuna Pruriens ◽  
Toxicity Tests ◽  
Sod Activity ◽  
Tropical Regions ◽  
Mediated Effects ◽  
Menstruation Disorders ◽  
Therapeutic Tools

Ethnopharmacological Relevance:Mucuna pruriens (Mp) belongs to Leguminosae family, it is native of tropical regions and used to treat several maladies such as urinary, neurological, and menstruation disorders, constipation, edema, fever, tuberculosis, ulcers, diabetes, arthritis, dysentery, and cardiovascular diseases. Mp seeds are rich in bioactive compounds, for instance, lectins, a heterogeneous group of proteins and glycoproteins with a potential role as therapeutic tools for several conditions, including gastric disorders. This study investigated the acute toxicity, gastroprotective, and antioxidant activities of a lectin from Mucuna pruriens seeds (MpLec) on ethanol-induced gastropathy model in mice.Materials & Methods:Mice received MpLec (5 or 10 mg/kg; i.v.) and were observed for acute toxicity signs; in another experimental series, mice were pre-treated with MpLec (0.001; 0.01 or 0.1 mg/kg, i.v.), ranitidine (80 mg/kg, p.o.), or saline (0.3 mL/30g, i.v.) before ethanol 99.9% (0.2 mL/animal, p.o.), and euthanized 30 min after ethanol challenge. Macroscopic and microscopic gastric aspects, biochemical parameters (tissue hemoglobin levels, iron-induced lipid peroxidation, GSH content, SOD activity, and gastric mucosal PGE2) were measured. Additionally, pharmacological tools (yohimbine, indomethacin, naloxone, L-NAME) were opportunely used to clarify MpLec gastroprotective mechanisms of action.Results:No toxicity signs nor death were observed at acute toxicity tests. MpLec reduced ethanol-induced gastric damage, edema, and hemorrhagic patches formation, as well as decreased lipid peroxidation, SOD activity, and increased GSH content. Yohimbine and indomethacin prevented MpLec effects, suggesting the involvement of alpha-2 adrenoceptors and prostaglandins in the MpLec-mediated effects.Conclusion:MpLec does not present toxicity signs and shows gastroprotective and antioxidant activities via alpha-2 adrenoceptors and prostaglandins in the ethanol-induced gastropathy model.

Detoxifying Action of Aqueous Extracts of Mucuna pruriens Seed and Mimosa pudica Root Against Venoms of Naja nigricollis and Bitis arietans

2020 ◽  
Vol 14 (2) ◽  
pp. 134-144 ◽  
Author(s):  
Matthew P. Ameh ◽  
Mamman Mohammed ◽  
Yusuf P. Ofemile ◽  
Magaji G. Mohammed ◽  
Ada Gabriel ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Plant Extracts ◽  
Fibrinolytic Activity ◽  
Neglected Tropical Diseases ◽  
World Health ◽  
Mucuna Pruriens ◽  
Phytochemical Analysis ◽  
Mimosa Pudica ◽  
Health Organization

Background: The World Health Organization included snakebite envenomation among Neglected Tropical Diseases in 2017. The importance of natural products from plants is enormous, given that most prescribed drugs originate from plants. Among this is Mucuna pruriens and Mimosa pudica, with many registered patents asserting their health benefits. Objective: This study investigated the in vitro neutralizing effects of Mucuna pruriens seed and Mimosa pudica root extracts on venoms of Naja nigricollis and Bitis arietans. Methods: In mice, the LD50 and phytochemical analysis of M. pruriens and M. pudica plant extracts were carried out prior to the evaluation of their haemolytic and fibrinolytic effect. Their effects on the activities of phospholipase A2 (PLA2) were also assessed. Results: At a concentration of 50 mg/ml, both plant extracts were found to neutralize the fibrinolytic activity of N. nigricollis, but 400 mg/ml was required to neutralize the fibrinolytic activity of B. arietans. In haemolytic studies, 50 mg/ml concentration of M. pruriens extract suppressed haemolysis caused by N. nigricollis venom by 70% but at the same concentration, M. pudica extract reduced haemolysis by 49.4%. M. pruriens, at 50 mg/ml concentration, only inhibited phospholipase A2 activity by 7.7% but higher concentrations up to 400mg/ml had no effect against the venom of N. nigricollis; at 200 mg/ml. M. pudica extract inhibited PLA2 activity by 23%. Conclusion: The results suggest that M. pruriens and M. pudica may be considered as promising antivenom agents for people living in a snake-bite prone environment.

Comparison of extraction efficiency of various methods to extract L-DOPA from Mucuna pruriens (L.) DC.

2017 ◽  
Vol 6 (04) ◽  
pp. 5343
Author(s):  
Ragni Vora ◽  
Ambika N. Joshi* ◽  
Nitesh C. Joshi
Keyword(s):  
Extraction Efficiency ◽  
Soxhlet Extraction ◽  
Extraction Methods ◽  
Mucuna Pruriens ◽  
Water Mixture ◽  
Uv Detector ◽  
Pharmacological Activities ◽  
Hplc Mobile Phase ◽  
Plant Sources ◽  
Seed Extracts

Mucuna pruriens seeds are noted to be a natural source of L-DOPA and are also used as a substitute for the synthetic L-DOPA. In the present study; attempts are made to develop suitable method(s) for extraction of L-DOPA from the powdered seeds of Mucuna pruriens using different solvents and conditions. The Seed powder was subjected to 7 different extraction methods and Method 1 was subjected to various solvent concentrations. Some methods used de-fatting procedure, either the method was cold maceration or in high temperature. Soxhlet extraction was also used in one of the extraction methods. All the extracts were analyzed using RP-HPLC. Mobile Phase used was Water: Methanol: AcetoNitrile (100:60:40) (v/v) containing 0.2% Triethylamine, pH = 3.3 and monitored at 280 nm with variable wavelength UV detector. The extraction was best with Methanol Water mixture in a cold maceration technique and overall gives good extraction efficiency of 13.36 % L-DOPA and id the best method giving highest extraction efficiency. The De-fatting method was the 2nd best methods giving approximately 8.8% L-DOPA and Method 5 viz, heat reflux method gives 8.7% L-DOPA making it the 3rd best method. There are not many studies done for optimization of extraction technique for L-DOPA despite an extensive work is reported for isolation, identification and pharmacological activities of L-DOPA from various plant sources. Keeping this in view, present investigation was done to study the extraction efficiency of various extraction methods of L-DOPA content in seed extracts of Mucuna pruriens and compare it.

scholarly journals Physical properties and water absorption kinetics of three varieties of Mucuna beans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ajibola B. Oyedeji ◽  
Olajide P. Sobukola ◽  
Ezekiel Green ◽  
Oluwafemi A. Adebo
Keyword(s):  
Physical Properties ◽  
Water Absorption ◽  
Rate Constant ◽  
Geometric Mean ◽  
Seed Mass ◽  
Activation Energies ◽  
Mucuna Pruriens ◽  
Absorption Kinetics ◽  
Kinetics Of ◽  
Soaking Temperature

AbstractThe physical properties and water absorption kinetics of three varieties of Mucuna beans (Mucuna pruriens, Mucuna rajada and Mucuna veracruz) were determined in this study. Physical properties including length, width, thickness, geometric mean diameter, sphericity, porosity, bulk density, area, volume and one thousand seed mass were calculated while hydration kinetics was studied by soaking Mucuna beans in water at 30 °C, 40 °C and 50 °C and measuring water uptake at 9 h interval. Peleg’s equation was used to model the hydration characteristics and Arrhenius equation was used to describe the effect of temperature on Peleg’s rate constant k1 and to obtain the activation energies for soaking. Significant variations were observed in almost all the physical properties of the different varieties, however, there were no significant differences (p < 0.05) in their thicknesses and bulk densities. The effectiveness of fit of Peleg’s model (R2) increased with increase in soaking temperature. Peleg’s rate constant k1 decreased with increase in soaking temperature while k2 increased with temperature increase. Activation energies of Mucuna pruriens, Mucuna rajada and Mucuna veracruz were 1613.24 kJ/mol, 747.95 kJ/mol and 2743.64 kJ/mol, respectively. This study provides useful information about the properties of three varieties of Mucuna beans that could be of importance to processors and engineers for process design and optimization.

The effect of some environmental factors on the production of L-DOPA by alginate-entrapped cells of Mucuna pruriens

Planta ◽  
1983 ◽  
Vol 158 (6) ◽  
pp. 482-486 ◽  
Author(s):  
Harm J. Wichers ◽  
Theo M. Malingr� ◽  
Hindrik J. Huizing
Keyword(s):  
Environmental Factors ◽  
Mucuna Pruriens

Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

2020 ◽  
Vol 73 ◽  
pp. 3-7 ◽  
Author(s):  
Natasha Fothergill-Misbah ◽  
Harshvadan Maroo ◽  
Momodou Cham ◽  
Gianni Pezzoli ◽  
Richard Walker ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Management ◽  
Low Income ◽  
Sub Saharan Africa ◽  
Low Income Countries ◽  
Mucuna Pruriens ◽  
Sub Saharan

The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

2016 ◽  
Vol 7 (1) ◽  
pp. 434-444 ◽  
Author(s):  
Francisco Herrera Chalé ◽  
Jorge Carlos Ruiz Ruiz ◽  
David Betancur Ancona ◽  
Juan José Acevedo Fernández ◽  
Maira Rubi Segura Campos
Keyword(s):  
Protein Hydrolysates ◽  
Mucuna Pruriens ◽  
Hypolipidemic Effect ◽  
Antithrombotic Activity ◽  
Protein Concentrates ◽  
Enzymatic Systems ◽  
Peptide Fractions

Hydrolysates and peptide fractions (PF) obtained fromM. pruriensprotein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities.

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