Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues

2018 ◽  
Vol 128 ◽  
pp. 401-407 ◽  
Author(s):  
Osvaldo Flores-Bastías ◽  
Eduardo Karahanian
Keyword(s):  
Alcohol Intake ◽  
Peroxisome Proliferator ◽  
Tnf Receptors ◽  
Melanocortin System ◽  
Heavy Alcohol ◽  
System A ◽  
Peroxisome Proliferator Activated Receptors ◽  
Heavy Alcohol Intake

scholarly journals Acute heavy alcohol intake increases silent myocardial ischaemia in patients with stable angina pectoris.

Heart ◽  
1996 ◽  
Vol 75 (6) ◽  
pp. 563-567 ◽  
Author(s):  
J. Rossinen ◽  
J. Partanen ◽  
P. Koskinen ◽  
L. Toivonen ◽  
M. Kupari ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Myocardial Ischaemia ◽  
Stable Angina ◽  
Alcohol Intake ◽  
Stable Angina Pectoris ◽  
Silent Myocardial Ischaemia ◽  
Heavy Alcohol ◽  
Heavy Alcohol Intake

Heavy alcohol intake, homocysteine and Type 2 diabetes

2005 ◽  
Vol 22 (10) ◽  
pp. 1359-1363 ◽  
Author(s):  
H. Sakuta ◽  
T. Suzuki ◽  
Y. Katayama ◽  
H. Yasuda ◽  
T. Ito
Keyword(s):  
Type 2 Diabetes ◽  
Alcohol Intake ◽  
Heavy Alcohol ◽  
Heavy Alcohol Intake

Changes in dopamine receptor sensitivity in humans after heavy alcohol intake

1985 ◽  
Vol 86 (1-2) ◽  
pp. 142-146 ◽  
Author(s):  
Jan Balldin ◽  
Christer Alling ◽  
C. G. Gottfries ◽  
G�ran Lindstedt ◽  
G�ran L�ngstr�m
Keyword(s):  
Dopamine Receptor ◽  
Alcohol Intake ◽  
Receptor Sensitivity ◽  
Heavy Alcohol ◽  
Heavy Alcohol Intake

Heavy alcohol intake and intracerebral hemorrhage: Characteristics and effect on outcome

Neurology ◽  
2012 ◽  
Vol 79 (11) ◽  
pp. 1109-1115 ◽  
Author(s):  
B. Casolla ◽  
N. Dequatre-Ponchelle ◽  
C. Rossi ◽  
H. Henon ◽  
D. Leys ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Alcohol Intake ◽  
Heavy Alcohol ◽  
Heavy Alcohol Intake

540 HEAVY ALCOHOL INTAKE INCREASES HEPATOCELLULAR CARCINOMA IN HEPATITIS B VIRUS-RELATED CIRRHOSIS

2013 ◽  
Vol 58 ◽  
pp. S221
Author(s):  
C.-W. Lin ◽  
L.-R. Mo ◽  
C.-Y. Chang ◽  
D.-S. Perng ◽  
G.-H. Lo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Alcohol Intake ◽  
Heavy Alcohol ◽  
B Virus ◽  
Heavy Alcohol Intake

Compared Evaluation Of Different Markers Of Heavy Alcohol Intake In A Group Of Subjects Assessed For Fitness To Drive

2019 ◽  
Author(s):  
Siddhi Bhivandkar ◽  
Muhammad Azeem Rao ◽  
Shumaila Tasleem ◽  
Saeed Ahmed ◽  
Muhammad Zeshan ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Fitness To Drive ◽  
Heavy Alcohol ◽  
Heavy Alcohol Intake

scholarly journals Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors

2020 ◽  
Vol 21 (19) ◽  
pp. 7026
Author(s):  
Leonardo Brunetti ◽  
Antonio Carrieri ◽  
Luca Piemontese ◽  
Paolo Tortorella ◽  
Fulvio Loiodice ◽  
...  
Keyword(s):  
Endocannabinoid System ◽  
Docking Study ◽  
Binding Mode ◽  
Peroxisome Proliferator ◽  
System A ◽  
Ppar Agonists ◽  
Peroxisome Proliferator Activated Receptors ◽  
Ppar Ligands ◽  
Faah Inhibitors ◽  
Further Development

In recent years, Peroxisome Proliferator-Activated Receptors (PPARs) have been connected to the endocannabinoid system. These nuclear receptors indeed mediate the effects of anandamide and similar substances such as oleoyl-ethanolamide and palmitoyl-ethanolamide. An increasing body of literature describing the interactions between the endocannabinoid system and PPARs has slowly but surely been accumulating over the past decade, and a multitarget approach involving these receptors and endocannabinoid degrading enzyme FAAH has been proposed for the treatment of inflammatory states, cancer, and Alzheimer’s disease. The lack of knowledge about compounds endowed with such an activity profile therefore led us to investigate a library of readily available, well-characterized PPAR agonists that we had synthesized over the years in order to find a plausible lead compound for further development. Moreover, we propose a rationalization of our results via a docking study, which sheds some light on the binding mode of these PPAR agonists to FAAH and opens the way for further research in this field.

Effect of heavy alcohol intake in the absence of liver disease on bone mass in black and white men.

1995 ◽  
Vol 80 (8) ◽  
pp. 2499-2503 ◽  
Author(s):  
C V Odvina ◽  
I Safi ◽  
C H Wojtowicz ◽  
E I Barengolts ◽  
P Lathon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bone Mass ◽  
Alcohol Intake ◽  
White Men ◽  
Heavy Alcohol ◽  
Black And White ◽  
Heavy Alcohol Intake
Sign in / Sign up

Export Citation Format

Share Document