A role of the norepinephrine system or effort in the interplay of different facets of inhibitory control

2022 ◽  
pp. 108143
Author(s):  
Shijing Yu ◽  
Filippo Ghin ◽  
Moritz Mückschel ◽  
Tjalf Ziemssen ◽  
Ann-Kathrin Stock ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Norepinephrine System

scholarly journals Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Peer Victimization ◽  
Inhibitory Control ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Chinese Han ◽  
Mediating Role ◽  
Adolescent Depressive Symptoms

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

A possible role of the norepinephrine system during sequential cognitive flexibility – Evidence from EEG and pupil diameter data

Cortex ◽  
2020 ◽  
Vol 128 ◽  
pp. 22-34 ◽  
Author(s):  
Franziska Giller ◽  
Moritz Mückschel ◽  
Tjalf Ziemssen ◽  
Christian Beste
Keyword(s):  
Cognitive Flexibility ◽  
Pupil Diameter ◽  
Norepinephrine System

scholarly journals On the interrelation of 1/f neural noise and norepinephrine system activity during motor response inhibition

2019 ◽  
Vol 121 (5) ◽  
pp. 1633-1643 ◽  
Author(s):  
Maik Pertermann ◽  
Moritz Mückschel ◽  
Nico Adelhöfer ◽  
Tjalf Ziemssen ◽  
Christian Beste
Keyword(s):  
Information Processing ◽  
Cognitive Control ◽  
Inhibitory Control ◽  
Response Inhibition ◽  
Pupil Diameter ◽  
Human Information Processing ◽  
System Activity ◽  
Neural Noise ◽  
Control Processes ◽  
Norepinephrine System

Several lines of evidence suggest that there is a close interrelation between the degree of noise in neural circuits and the activity of the norepinephrine (NE) system, yet the precise nexus between these aspects is far from being understood during human information processing and cognitive control in particular. We examine this nexus during response inhibition in n = 47 healthy participants. Using high-density EEG recordings, we estimate neural noise by calculating “1/ f noise” of those data and integrate these EEG parameters with pupil diameter data as an established indirect index of NE system activity. We show that neural noise is reduced when cognitive control processes to inhibit a prepotent/automated response are exerted. These neural noise variations were confined to the theta frequency band, which has also been shown to play a central role during response inhibition and cognitive control. There were strong positive correlations between the 1 /f neural noise parameter and the pupil diameter data within the first 250 ms after the Nogo stimulus presentation at centro-parietal electrode sites. No such correlations were evident during automated responding on Go trials. Source localization analyses using standardized low-resolution brain electromagnetic tomography show that inferior parietal areas are activated in this time period in Nogo trials. The data suggest an interrelation of NE system activity and neural noise within early stages of information processing associated with inferior parietal areas when cognitive control processes are required. The data provide the first direct evidence for the nexus between NE system activity and the modulation of neural noise during inhibitory control in humans. NEW & NOTEWORTHY This is the first study showing that there is a nexus between norepinephrine system activity and the modulation of neural noise or scale-free neural activity during inhibitory control in humans. It does so by integrating pupil diameter data with analysis of EEG neural noise.

Do bilingual and monolingual preschoolers acquire false belief understanding similarly? The role of executive functioning and language

2018 ◽  
Vol 38 (4) ◽  
pp. 382-398 ◽  
Author(s):  
Vanessa Diaz ◽  
M. Jeffrey Farrar
Keyword(s):  
Executive Functioning ◽  
Inhibitory Control ◽  
Language Proficiency ◽  
Short Term Memory ◽  
Language Ability ◽  
False Belief ◽  
Bilingual Children ◽  
Short Term ◽  
False Belief Understanding

Bilingual children often show advanced executive functioning (EF) and false belief (FB) understanding compared to monolinguals. The latter has been attributed to their enhanced inhibitory control EF, although this has only been examined in a single study which did not confirm this hypothesis. The current study examined the relation of EF and language proficiency on FB reasoning in bilingual and monolingual preschoolers to answer two questions: (1) Are there differences in bilinguals’ and monolinguals’ FB, language proficiency, and EF? If so, (2) is there a differential role for language proficiency and EF in predicting FB reasoning in these two groups? Thirty-two Spanish–English bilinguals and 33 English monolinguals (three to five years old) were compared. While monolinguals outperformed bilinguals on language proficiency, after controlling for this, bilinguals outperformed monolinguals on FB reasoning, and marginally on EF. General language ability was related to FB performance in both groups, while short-term memory and inhibitory control predicted FB only for monolinguals.

scholarly journals Inhibitory control and problematic Internet-pornography use – The important balancing role of the insula

2020 ◽  
Vol 9 (1) ◽  
pp. 58-70
Author(s):  
Stephanie Antons ◽  
Brand Matthias
Keyword(s):  
Image Processing ◽  
Inhibitory Control ◽  
Symptom Severity ◽  
Inferior Frontal Gyrus ◽  
Dual Process ◽  
Stop Signal Task ◽  
Addictive Behaviors ◽  
Control Performance ◽  
Internet Pornography

Abstract Background and aims Diminished control over a specific behavior is a core characteristic in addictive behaviors such as problematic Internet-pornography (IP) use. First studies suggest that a hyperactivity of the impulsive system is one reason for impulsive behaviors in the context of problematic IP use. The tripartite-process theory of addiction explains neurocognitive mechanisms beyond common dual-process theories in addictive behaviors. However, the role of the reflective and interoceptive system is still unresolved. Methods The study comprised a stop-signal task (SST) including neutral and pornographic images during fMRI and questionnaires to investigate associations between symptoms of problematic IP use, craving, and neural activity of the impulsive, reflective, and interoceptive system. We examined 28 heterosexual males with varying symptom severity of problematic IP use. Results Data indicates that individuals with more symptoms of problematic IP use showed better performance in the SST which was linked to decreased insula and inferior frontal gyrus activity during pornographic image processing. An increase in craving was associated with lower activity of the ventral striatum during pornographic image processing. The interoceptive system showed varying effects. Increased insula activity during inhibitory control and decreased activity during pornographic image processing were associated with higher inhibitory control performance. Discussion and Conclusion Effects of tolerance and motivational aspects may explain the better inhibitory control performance in individuals with higher symptom severity which was associated with differential activity of the interoceptive and reflective system. Diminished control over IP use presumably results from the interaction between the impulsive, reflective, and interoceptive systems.

scholarly journals The Role of Inhibitory Control in Second Language Phonological Processing

2016 ◽  
Vol 66 (4) ◽  
pp. 741-773 ◽  
Author(s):  
Isabelle Darcy ◽  
Joan C. Mora ◽  
Danielle Daidone
Keyword(s):  
Second Language ◽  
Inhibitory Control ◽  
Phonological Processing

scholarly journals Intracellular and Computational Characterization of the Intracortical Inhibitory Control of Synchronized Thalamic Inputs In Vivo

1997 ◽  
Vol 78 (1) ◽  
pp. 335-350 ◽  
Author(s):  
Diego Contreras ◽  
Alain Destexhe ◽  
Mircea Steriade
Keyword(s):  
Inhibitory Control ◽  
Computational Models ◽  
Pyramidal Cells ◽  
Excitatory Postsynaptic Potential ◽  
Thalamic Stimulation ◽  
Postsynaptic Potential ◽  
Spike Wave

Contreras, Diego, Alain Destexhe, and Mircea Steriade. Intracellular and computational characterization of the intracortical inhibitory control of synchronized thalamic inputs in vivo. J. Neurophysiol. 78: 335–350, 1997. We investigated the presence and role of local inhibitory cortical control over synchronized thalamic inputs during spindle oscillations (7–14 Hz) by combining intracellular recordings of pyramidal cells in barbiturate-anesthetized cats and computational models. The recordings showed that 1) similar excitatory postsynaptic potential (EPSP)/inhibitory postsynaptic potential (IPSP) sequences occurred either during spindles or following thalamic stimulation; 2) reversed IPSPs with chloride-filled pipettes transformed spindle-related EPSP/IPSP sequences into robust bursts with spike inactivation, resembling paroxysmal depolarizing shifts during seizures; and 3) dual simultaneous impalements showed that inhibition associated with synchronized thalamic inputs is local. Computational models were based on reconstructed pyramidal cells constrained by recordings from the same cells. These models showed that the transformation of EPSP/IPSP sequences into fully developed spike bursts critically needs a relatively high density of inhibitory currents in the soma and proximal dendrites. In addition, models predict significant Ca2+ transients in dendrites due to synchronized thalamic inputs. We conclude that synchronized thalamic inputs are subject to strong inhibitory control within the cortex and propose that 1) local impairment of inhibition contributes to the transformation of spindles into spike-wave-type discharges, and 2) spindle-related inputs trigger Ca2+ events in cortical dendrites that may subserve plasticity phenomena during sleep.

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