Misaligned core body temperature rhythms impact cognitive performance of hospital shift work nurses

Circadian misalignment between sleep and behavioral/feeding rhythms is thought to lead to various health impairments in shift workers. Therefore, we investigated how shift work leads to genome-wide circadian dysregulation in hospital nurses. Female nurses from the University of Alabama at Birmingham (UAB) Hospital working night shift ( n = 9; 29.6 ± 11.4 y) and day shift ( n = 8; 34.9 ± 9.4 y) participated in a 9-day study measuring locomotor activity and core body temperature (CBT) continuously. Additionally, cortisol and melatonin were assayed and peripheral blood mononuclear cells (PBMCs) were harvested for RNA extraction every 3 h on a day off from work. We saw phase desynchrony of core body temperature, peak cortisol, and dim light melatonin onset in individual night-shift subjects compared with day-shift subjects. This variability was evident even though day- and night-shift nurses had similar sleep timing and scheduled meal times on days off. Surprisingly, the phase and rhythmicity of the expression of the clock gene, PER1, in PBMCs were similar for day-shift and night-shift subjects. Genome-wide microarray analysis of PBMCs from a subset of nurses revealed distinct gene expression patterns between night-shift and day-shift subjects. Enrichment analysis showed that day-shift subjects expressed pathways involved in generic transcription and regulation of signal transduction, whereas night-shift subjects expressed pathways such as RNA polymerase I promoter opening, the matrisome, and endocytosis. In addition, there was large variability in the number of rhythmic transcripts among subjects, regardless of shift type. Interestingly, the amplitude of the CBT rhythm appeared to be more consistent with the number of cycling transcripts for each of the 6 subjects than was melatonin rhythm. In summary, we show that shift-work patterns affect circadian alignment and gene expression in PBMCs.

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Non-invasive monitoring of core body temperature rhythms over 72h in 10 bedridden elderly patients with disorders of consciousness in a Japanese hospital: A pilot study

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2013.05.009 ◽

2013 ◽

Vol 57 (3) ◽

pp. 428-432 ◽

Cited By ~ 10

Author(s):

Masaru Matsumoto ◽

Junko Sugama ◽

Mayumi Okuwa ◽

Misako Dai ◽

Junko Matsuo ◽

...

Keyword(s):

Pilot Study ◽

Body Temperature ◽

Elderly Patients ◽

Core Body Temperature ◽

Disorders Of Consciousness ◽

Invasive Monitoring ◽

Non Invasive ◽

Temperature Rhythms ◽

Core Body

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Disturbances in Melatonin, Cortisol and Core Body Temperature Rhythms after Major Surgery

World Journal of Surgery ◽

10.1007/s00268-006-0256-5 ◽

2006 ◽

Vol 31 (2) ◽

pp. 290-298 ◽

Cited By ~ 44

Author(s):

Ismail Gögenur ◽

Ubbat Ocak ◽

Ömer Altunpinar ◽

Benita Middleton ◽

Debra J. Skene ◽

...

Keyword(s):

Body Temperature ◽

Core Body Temperature ◽

Major Surgery ◽

Temperature Rhythms ◽

Core Body

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Rapid phase adjustment of melatonin and core body temperature rhythms following a 6-h advance of the light/dark cycle in the horse

Journal of Circadian Rhythms ◽

10.1186/1740-3391-5-5 ◽

2007 ◽

Vol 5 (0) ◽

pp. 5 ◽

Cited By ~ 16

Author(s):

Barbara A Murphy ◽

Jeffrey A Elliott ◽

Dawn R Sessions ◽

Mandi M Vick ◽

Erin L Kennedy ◽

...

Keyword(s):

Body Temperature ◽

Core Body Temperature ◽

Dark Cycle ◽

Rapid Phase ◽

Phase Adjustment ◽

Temperature Rhythms ◽

Core Body

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Body Temperature Is Associated With Cognitive Performance in Older Adults With and Without Mild Cognitive Impairment: A Cross-sectional Analysis

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.585904 ◽

2021 ◽

Vol 13 ◽

Author(s):

Patrick Eggenberger ◽

Michael Bürgisser ◽

René M. Rossi ◽

Simon Annaheim

Keyword(s):

Older Adults ◽

Body Temperature ◽

Skin Temperature ◽

Cognitive Performance ◽

Core Body Temperature ◽

Single Point ◽

Body Temperatures ◽

Core Body ◽

Temperature Amplitude

Wearable devices for remote and continuous health monitoring in older populations frequently include sensors for body temperature measurements (i.e., skin and core body temperatures). Healthy aging is associated with core body temperatures that are in the lower range of age-related normal values (36.3 ± 0.6°C, oral temperature), while patients with Alzheimer’s disease (AD) exhibit core body temperatures above normal values (up to 0.2°C). However, the relation of body temperature measures with neurocognitive health in older adults remains unknown. This study aimed to explore the association of body temperature with cognitive performance in older adults with and without mild cognitive impairment (MCI). Eighty community-dwelling older adults (≥65 years) participated, of which 54 participants were cognitively healthy and 26 participants met the criteria for MCI. Skin temperatures at the rib cage and the scapula were measured in the laboratory (single-point measurement) and neuropsychological tests were conducted to assess general cognitive performance, episodic memory, verbal fluency, executive function, and processing speed. In a subgroup (n = 15, nine healthy, six MCI), skin and core body temperatures were measured continuously during 12 h of habitual daily activities (long-term measurement). Spearman’s partial correlation analyses, controlled for age, revealed that lower median body temperature and higher peak-to-peak body temperature amplitude was associated with better general cognitive performance and with better performance in specific domains of cognition; [e.g., rib median skin temperature (single-point) vs. processing speed: rs = 0.33, p = 0.002; rib median skin temperature (long-term) vs. executive function: rs = 0.56, p = 0.023; and peak-to-peak core body temperature amplitude (long-term) vs. episodic memory: rs = 0.51, p = 0.032]. Additionally, cognitively healthy older adults showed lower median body temperature and higher peak-to-peak body temperature amplitude compared to older adults with MCI (e.g., rib median skin temperature, single-point: p = 0.035, r = 0.20). We conclude that both skin and core body temperature measures are potential early biomarkers of cognitive decline and preclinical symptoms of MCI/AD. It may therefore be promising to integrate body temperature measures into multi-parameter systems for the remote and continuous monitoring of neurocognitive health in older adults.

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Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease

Neurobiology of Aging ◽

10.1016/0197-4580(95)00059-n ◽

1995 ◽

Vol 16 (5) ◽

pp. 765-771 ◽

Cited By ~ 142

Author(s):

Andrew Satlin ◽

Ladislav Volicer ◽

Edward G. Stopa ◽

David Harper

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Locomotor Activity ◽

Body Temperature ◽

Core Body Temperature ◽

Temperature Rhythms ◽

Core Body

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Effects of intermittent cold exposure varying in intensity on core body temperature and resting heat production of beef cattle

Canadian Journal of Animal Science ◽

10.4141/a00-118 ◽

2001 ◽

Vol 81 (4) ◽

pp. 459-465 ◽

Cited By ~ 6

Author(s):

R. D. Bergen ◽

A. D. Kennedy ◽

R. J. Christopherson

Keyword(s):

Body Temperature ◽

Beef Cattle ◽

Heat Production ◽

Cold Exposure ◽

Core Body Temperature ◽

Daily Maximum ◽

Adaptation Period ◽

Temperature Rhythms ◽

Core Body ◽

Vaginal Temperature

Crossbred beef heifers (n = 18) fed at 1.3× maintenance were exposed to summer daytime temperatures (20 ± 0.2°C) for 8 h (08:00 until 16:00) and to control (22°C), moderate (–6°C) or cold (–15°C) environments for 16 h daily (16:00 until 08:00) for a minimum 21-d adaptation period to investigate the effects of in tensity of intermittent cold exposure on vaginal temperature and resting heat production. Resting heat production was measured at the end of the adaptation period. Vaginal temperature was continuously monitored throughout the experiment using radiotelemetry. Vaginal temperature increased immediately after the onset of cold exposure in both moderate and cold treatments, peaked after 3 h, and returned to pre-exposure levels by the time the 16-h treatment ended. In contrast, vaginal temperatures of control heifers peaked only after feeding at 08:30. Treatment did not affect daily maximum (P= 0.60), mean (P = 0.72) or minimum (P = 0.34) vaginal temperatures, but heifers in both cold-exposed treatments spent more time (P = 0.03) with vaginal temperatures exceeding the daily mean vaginal temperature than control heifers. Compared to control heifers, the variability of vaginal temperature increased 1.8- and 2.2-fold in the moderate and cold treatments, respectively (P = 0.04), and did not change with time (P = 0.98 ). Resting heat production did not increase following 21 d of exposure to moderate and cold conditions. Results of this study indicate that intermittent cold exposure influenced circadian body temperature rhythms without increasing resting heat production. Key words: Beef cattle, thermoregulation, vaginal temperature, heat production.

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Core body temperature rhythms in circadian rhythm sleep disorder, irregular sleep-wake type

Psychiatry and Clinical Neurosciences ◽

10.1111/j.1440-1819.2011.02279.x ◽

2011 ◽

Vol 65 (7) ◽

pp. 679-680 ◽

Cited By ~ 1

Author(s):

Eriko Narita ◽

Masaru Echizenya ◽

Masahiro Takeshima ◽

Yoshiyuki Inomata ◽

Tetsuo Shimizu

Keyword(s):

Circadian Rhythm ◽

Body Temperature ◽

Sleep Disorder ◽

Core Body Temperature ◽

Circadian Rhythm Sleep Disorder ◽

Temperature Rhythms ◽

Core Body

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Circadian temperature rhythms in rabbit pups and in their does

Laboratory Animals ◽

10.1258/0023677011911831 ◽

2001 ◽

Vol 35 (4) ◽

pp. 364-373 ◽

Cited By ~ 35

Author(s):

B. Jilge ◽

B. Kuhnt ◽

W. Landerer ◽

S. Rest

Keyword(s):

Body Temperature ◽

Core Body Temperature ◽

Circadian Oscillator ◽

Suprachiasmatic Nuclei ◽

The Core ◽

Temperature Rhythm ◽

Pregnancy And Lactation ◽

Temperature Rhythms ◽

Milk Ingestion ◽

Core Body

Circadian rhythms of mammals are generated endogenously, the master oscillator system residing in the suprachiasmatic nuclei (SCN). Previous experiments have indicated that the rabbit has a feeding entrainable circadian oscillator (FEO) which is supposed to be of greatest importance during the early infancy of the rabbit. Here we report the course of telemetrically monitored core body temperature of rabbit pups and of their does. Temperature increased from 37.6 ± 0.3 °C on day 2 to 39.5 ± 0.1 °C on day 28 of life. The pups showed a 24 h temperature rhythm even during their first days of life. Temperature increased 2½-3 h prior to nursing for 0.4-0.8 °C and rose for an additional 0.4-0.6 °C immediately after milk ingestion. The anticipatory, but not the postprandial component persisted when nursing was skipped twice. The persistence of a rhythm in the absence of any entraining agent is crucial for its endogenous generation. In the doe, the core body temperature gradually decreased during the last 2/3 of pregnancy. During parturition it steeply rose for 1.5-1.7 °C and attained a plateau of 39.7 ± 0.2 °C during lactation. The circadian rhythm persisted during the whole course of pregnancy and lactation. Thus, in the rabbit an endogenous, feeding entrainable circadian oscillator appears to operate from the first days of life. It is of functional significance in that it alerts the pup in time so that it is able to utilize the singular short presence of the doe for maximal milk intake.

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