Association between Behavioural Risk Factors and Metabolic Syndrome among Adult Population in India: A Systematic Review and Meta-Analysis of Observational Studies

Introduction. Metabolic syndrome (MetS) is an assemblage of interconnected cardiovascular risk factors that are prevalent among children and adolescents in high-income countries (HICs). Despite the presence of several studies on the issue, the study findings are incongruent due to the absence of a gold standard diagnostic method of MetS in children. Thus, the findings of the original studies are inconclusive for policy makers and other stakeholders. This systematic review and meta-analysis is aimed at giving conclusive evidence about MetS among children and adolescents in HICs. Methods. We conducted searches using electronic databases (PubMed, Scopus, Web of Science, CINAHL (EBSCOhost), EMBASE (Elsevier), and Medline (EBSCOhost)) and other sources (Google Scholar and Google) up to September 2020. Observational studies reporting the prevalence of MetS were eligible in this study. The pooled estimates were computed in fixed and random effect models using six diagnostic methods (IDF, ATP III, de Ferranti et al., WHO, Weiss et al., and Cruz and Goran). Publication bias was verified using funnel plots and Egger’s regression tests. Subgroup and sensitivity analysis were performed in case of higher heterogeneities among the included studies. Result. In this study, 77 studies with a total population of 125,445 children and adolescents were used in the final analysis. Metabolic syndrome among the overweight and obese population was computed from 28 studies with the pooled prevalence of 25.25%, 24.47%, 39.41%, 29.52%, and 33.36% in IDF, ATP III, de Ferranti et al., WHO, and Weiss et al. criteria, respectively. Likewise, 49 studies were eligible to compute the pooled prevalence of MetS in the general population of children and adolescents. Hence, MetS was found in 3.70% (IDF), 5.40% (ATP III), 14.78% (de Ferranti et al.), 3.90% (WHO), and, 4.66% (Cruz and Goran) of study participants. Regarding the components of MetS, abdominal obesity in the overweight and obese population, and low HDL-C in the general population were the most common components. Besides, the prevalence of Mets among males was higher than females. Conclusion. This study demonstrates that MetS among children and adolescents is undoubtedly high in HICs. The prevalence of MetS is higher among males than females. Community-based social and behavioral change communications need to be designed to promote healthy eating behaviors and physical activities. Prospective cohort studies could also help to explore all possible risk factors of MetS and to design specific interventions accordingly.

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Faculty Opinions recommendation of Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6105964.6144055 ◽

2010 ◽

Author(s):

Erik Buskens ◽

Henk Groen

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Observational Studies ◽

Meta Analysis ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Hormone Binding ◽

The Metabolic Syndrome

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The association of dietary energy density and the risk of obesity, type 2 diabetes and metabolic syndrome: a systematic review and meta‐analysis of observational studies

International Journal of Clinical Practice ◽

10.1111/ijcp.14291 ◽

2021 ◽

Author(s):

Elham Bazshahi ◽

Fatemeh Sheikhhossein ◽

Mohammad Reza Amini ◽

Sakineh Shab‐Bidar

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Energy Density ◽

Observational Studies ◽

Meta Analysis ◽

Dietary Energy ◽

Dietary Energy Density

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Metabolic syndrome and dietary patterns: a systematic review and meta-analysis of observational studies

European Journal of Nutrition ◽

10.1007/s00394-016-1305-y ◽

2016 ◽

Vol 56 (3) ◽

pp. 925-947 ◽

Cited By ~ 82

Author(s):

Míriam Rodríguez-Monforte ◽

Emília Sánchez ◽

Francisco Barrio ◽

Bernardo Costa ◽

Gemma Flores-Mateo

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Dietary Patterns ◽

Observational Studies ◽

Meta Analysis

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The prevalence and risk factors of work-related musculoskeletal disorders among adults in Ethiopia: a study protocol for extending a systematic review with meta-analysis of observational studies

Systematic Reviews ◽

10.1186/s13643-020-01403-9 ◽

2020 ◽

Vol 9 (1) ◽

Author(s):

Tsiwaye Gebreyesus ◽

Kalkidan Nigussie ◽

Moges Gashaw ◽

Balamurugan Janakiraman

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Musculoskeletal Disorders ◽

Observational Studies ◽

Meta Analysis ◽

Abstract Data ◽

Size Type ◽

The Individual

Abstract Background Work-related musculoskeletal disorders impose a significant and most often underappreciated burden to the individual, nation, healthcare system, and society as a whole. To the best of our knowledge, there is a lack of reliable estimates on the prevalence of work-related musculoskeletal disorders in Ethiopia. The objective of this study will be to assess the existing literature on the prevalence rates and determinant factors of work-related musculoskeletal disorders in Ethiopia. Method We will search PubMed/MEDLINE, Embase, SCOPUS, PsycINFO, PEDro, and Ebsco (from January 2000 onwards). Gray literature will be identified through searching Google Scholar and dissertation databases. Observational studies reporting on the prevalence of work-related musculoskeletal disorders among adult Ethiopians will be included. The primary outcome will be the prevalence of work-related musculoskeletal disorders. Secondary outcomes will be the prevalence of any risk factors in association with work-related musculoskeletal disorders. Two reviewers will independently screen all citations, full-text articles, and abstract data. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Subgroup analyses will be conducted to explore the potential sources of heterogeneity (e.g., gender, sample size, type of occupation). Publication bias and heterogeneity between the included studies will also be assessed and reported. Discussion This systematic review will provide a synthesis of the literature on the prevalence of work-related musculoskeletal disorders and their risk factors in Ethiopia. The results of this review could help the policymakers in occupational health and healthcare sectors in identifying priority areas for interventions in work-related musculoskeletal disorders and will also serve as a baseline for the decision-making processes of musculoskeletal health promotion, work exposure implementations, and prevention programs in workplaces. Systematic review registration PROSPERO, CRD42020164240

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Dietary acid load and cardiometabolic risk factors: a systematic review and meta-analysis of observational studies

Public Health Nutrition ◽

10.1017/s1368980019001125 ◽

2019 ◽

Vol 22 (15) ◽

pp. 2823-2834 ◽

Cited By ~ 1

Author(s):

Elnaz Daneshzad ◽

Fahimeh Haghighatdoost ◽

Leila Azadbakht

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Blood Pressure ◽

Observational Studies ◽

Cardiometabolic Risk ◽

Meta Analysis ◽

Cardiometabolic Risk Factors ◽

Cross Sectional ◽

Dietary Acid ◽

Acid Load

AbstractObjective:Dietary acid load (DAL) might contribute to change the levels of cardiometabolic risk factors; however, the results are conflicting. The present review was conducted to determine the relationship between DAL and cardiometabolic risk factors.Design:Systematic review and meta-analysis.Setting:A systematic search was conducted in electronic databases including ISI Web of Science, PubMed/MEDLINE, Scopus and Google Scholar for observational studies which assessed cardiometabolic risk factors across DAL. Outcomes were lipid profile, glycaemic factors and anthropometric indices. Effect sizes were derived using a fixed- or random-effect model (DerSimonian–Laird). Also, subgroup analysis was performed to find the probable source of heterogeneity. Egger’s test was performed for finding any publication bias.Results:Thirty-one studies were included in the current review with overall sample size of 92 478. There was a significant relationship between systolic blood pressure (SBP; weighted mean difference (WMD) = 1·74 (95 % CI 0·25, 3·24) mmHg;P= 0·022;I2= 95·3 %), diastolic blood pressure (DBP; WMD = 0·75 (95 % CI 0·07, 1·42) mmHg;P= 0·030;I2= 80·8 %) and DAL in cross-sectional studies. Serum lipids, glycaemic parameters including fasting blood sugar, glycated Hb, serum insulin, homeostatic model assessment of insulin resistance and waist circumference had no significant relationship with DAL. No publication bias was found. BMI was not associated with DAL in both cross-sectional and cohort studies.Conclusions:Higher DAL is associated with increased SBP and DBP. More studies are needed to find any relationship of DAL with lipid profile and glycaemic factors.

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A posteriori dietary patterns and metabolic syndrome in adults: a systematic review and meta-analysis of observational studies

Public Health Nutrition ◽

10.1017/s1368980018000216 ◽

2018 ◽

Vol 21 (9) ◽

pp. 1681-1692 ◽

Cited By ~ 11

Author(s):

Sakineh Shab-Bidar ◽

Mahdieh Golzarand ◽

Mina Hajimohammadi ◽

Sara Mansouri

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Dietary Patterns ◽

Dietary Pattern ◽

Observational Studies ◽

Meta Analysis ◽

A Posteriori ◽

Significant Positive Association ◽

Western Dietary Pattern ◽

Increased Risk

AbstractObjectiveObservational studies reported potential associations between different dietary patterns and the risk of metabolic syndrome (MetS); however, a consistent perspective has not been established to date. The current systematic review and meta-analysis aimed to evaluate the relationship between a posteriori dietary patterns and MetS by pooling available data.DesignMEDLINE and EMBASE databases were searched for relevant articles published up to July 2015 with no time restriction and with English language restriction. Two independent reviewers completed study selection and data extraction. Random-effects models (DerSimonian–Laird method) were used to pool effect sizes of eligible studies. The potential sources of heterogeneity were assessed using the I2 statistic.ResultsNineteen papers that identified dietary patterns using an a posteriori method were selected and included in the meta-analysis. The ‘Healthy/Prudent’ dietary pattern was inversely associated with risk of MetS (OR=0·89; 95 % CI 0·84, 0·94, P=0·002). In contrast, the ‘Unhealthy/Western’ dietary pattern had a significant positive association with risk of MetS (OR=1·16; 95 % CI 1·11, 1·22, P<0·001).ConclusionsOur findings provide evidence that greater adherence to a healthy/prudent dietary pattern is associated with a lower risk of MetS, while an unhealthy/Western dietary pattern is associated with increased risk of MetS. These data suggest that a diet based on healthy food choices is also beneficial for prevention of MetS.

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Environmental risk factors of leptospirosis in urban settings: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2018-023359 ◽

2019 ◽

Vol 9 (1) ◽

pp. e023359

Author(s):

Mohd Hatta Abdul Mutalip ◽

Mohd Amierul Fikri Mahmud ◽

Noor Aliza Lodz ◽

Norzawati Yoep ◽

Eida Nurhadzira Muhammad ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Environmental Risk ◽

Observational Studies ◽

Data Extraction ◽

Meta Analysis ◽

Environmental Risk Factors ◽

Primary Data ◽

Urban Settings ◽

Susceptible Populations

IntroductionLeptospirosis is the most common zoonotic disease that causes morbidity and mortality worldwide. The disease can cause sporadic epidemics and recent epidemics have become more apparent in urban localities. There is lack of documented evidence on the specific risk factors of leptospirosis infection among the urbanites, thereby impeding initiatives for prevention in urban settings. We aim to systematically search published articles and synthesise evidence on the risk factors associated with leptospirosis infection among the susceptible populations in urban localities, particularly to identify the risk factors of non-recreational leptospirosis infection.Methods and analysisWe will conduct a systematic review of observational studies that investigated environmental risk factors of leptospirosis in urban localities. The search will be performed for any eligible articles from selected electronic databases from 1970 until May 2018. The study will include any studies that investigated risk factors of confirmed leptospirosis cases who acquired the infection in urban locality, particularly exposures from the non-recreational and non-water-related activities. Study selection and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Meta-Analysis of Observational Studies in Epidemiology guideline. All data will be extracted using a standardised data extraction form and quality of the studies will be assessed using the Newcastle-Ottawa Scale guideline. Descriptive and meta-analysis will be performed by calculating the standardised median ORs and risk ratios for types of the non-recreational risk factors stratified by social, living conditions and environmental exposures, types of reservoirs and transmissions and types of activities and employments associated with leptospirosis infection in urban locality.Ethics and disseminationNo primary data will be collected thus no formal ethical approval is required. The results will be disseminated though a peer-reviewed publication and conference presentation.PROSPERO registration numberCRD42018090820.

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