scholarly journals Neurometabolic effects of sweetened solution intake during adolescence related to depressive-like phenotype in rats

Nutrition ◽  
2020 ◽  
Vol 75-76 ◽  
pp. 110770
Author(s):  
Danusa Mar Arcego ◽  
Laura Bem Olivo ◽  
Rafael Oliveira Moraes ◽  
Emily dos Santos Garcia ◽  
Ana Caroline Silveira ◽  
...  
Keyword(s):  
2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Nadine Zeeni ◽  
Nathalie Gharibeh ◽  
Nicolas Darcel ◽  
Gilles Fromentin ◽  
Daniel Tome ◽  
...  

2020 ◽  
Vol 318 (5) ◽  
pp. R870-R885
Author(s):  
Kellie M. Hyde ◽  
Ginger D. Blonde ◽  
Marco Bueter ◽  
Carel W. le Roux ◽  
Alan C. Spector

In rodents, Roux-en-Y gastric bypass (RYGB) decreases intake of, and preference for, foods or fluids that are high in sugar. Whether these surgically induced changes are due to decreases in the palatability of sugar stimuli is controversial. We used RYGB and sham-operated (SHAM) female rats to test the influence of prolonged ingestive experience with sugar solutions on the motivational potency of these stimuli to drive licking in brief-access (BA) tests. In experiment 1, RYGB attenuated intake of, and caloric preference for, 0.3 M sucrose during five consecutive, 46-h two-bottle tests (TBTs; sucrose). A second series of TBTs (5 consecutive, 46-h tests) with 1.0 M sucrose revealed similar results, except fluid preference for 1.0 M sucrose also significantly decreased. Before, between, and after the two series of TBTs, two sessions of BA tests (30 min; 10-s trials) with an array of sucrose concentrations (0 and 0.01–1.0 M) were conducted. Concentration-dependent licking and overall trial initiation did not differ between surgical groups in any test. In a similar experimental design in a second cohort of female rats, 0.6 and 2.0 M glucose (isocaloric with sucrose concentrations in experiment 1) were used in the TBTs; 0 and 0.06-2.0 M glucose were used in the BA tests. Outcomes were similar to those for experiment 1, except RYGB rats initiated fewer trials during the BA tests. Although RYGB profoundly affected intake of, and caloric preference for, sugar solutions and, with high concentrations, fluid preference, RYGB never influenced the motivational potency of sucrose or glucose to drive concentration-dependent licking in BA tests.


2017 ◽  
Vol 124 (4) ◽  
pp. 1174-1178 ◽  
Author(s):  
Toshie Shiraishi ◽  
Dai Kurosaki ◽  
Mitsuyo Nakamura ◽  
Taiji Yazaki ◽  
Satomi Kobinata ◽  
...  

Sensors ◽  
2021 ◽  
Vol 21 (17) ◽  
pp. 5816
Author(s):  
Piotr Słobodzian ◽  
Krzysztof Szostak ◽  
Katarzyna Skowronek ◽  
Laura Jasińska ◽  
Karol Malecha

In this paper, we describe a low-cost microwave microfluidic system of ultrahigh sensitivity for detecting small changes in the concentration of polar solutions (liquid dielectrics) in the 2.4 GHz ISM band. Its principle of operation is based on microwave interferometry, which is implemented using planar microstrip lines and integrated microwave components. The key features of this system include small solution intake (<200 µL per measurement), short time of measurement (ca. 20 ms), ultrahigh sensitivity of concentration changes (up to 55 dB/%), and low error of measurement (below 0.1%). The ultrahigh sensitivity was proven experimentally by measurements of the fat content of milk. In addition, it is a user-friendly system due to an effortless and fast calibration procedure. Moreover, it can be made relatively compact (<20 cm2) and features low power consumption (200 mW). Thus, the proposed system is perfect for industrial applications, especially for highly integrated lab-on-chip devices.


2002 ◽  
Vol 282 (1) ◽  
pp. R235-R243 ◽  
Author(s):  
Lucia F. Franchini ◽  
Alan Kim Johnson ◽  
José de Olmos ◽  
Laura Vivas

We evaluated serotonergic hindbrain groups of cells for their involvement in the generation and inhibition of sodium appetite. For that purpose, we analyzed the number of Fos-immunoreactive (Fos-ir) cells and double-labeled Fos-serotonin (5-HT)-ir neurons within different nuclei of the hindbrain raphe system and the area postrema (AP). Sodium depletion and sodium appetite were induced by peritoneal dialysis. Twenty-four hours after peritoneal dialysis, a 2% NaCl solution intake test was given to peritoneal dialyzed animals [PD-with access (PD-A) group] and to control dialyzed animals [CD-with access (CD-A) group]. Two additional groups of animals received either peritoneal dialysis or control dialysis but were not given access to the 2% NaCl [CD-no access (CD-NA) group or PD-no access (PD-NA) group]. The number of Fos-ir neurons within different nuclei of the raphe system was increased in spontaneous and induced sodium ingestion of CD-A and PD-A groups compared with the CD-NA and PD-NA groups. The PD-NA group had significantly fewer double-labeled cells along the raphe system compared with the animals in near-normal sodium balance (CD-NA and CD-A) or in the process of restoring sodium balance by consuming NaCl (PD-A). The AP of the PD-A group showed a significant increase in the number of Fos-ir and Fos-5-HT-ir cells compared with the PD-NA and CD groups. Our results suggest that serotonergic pathways with cell bodies in the AP and the raphe system are involved in the control of sodium appetite.


Neuroreport ◽  
2009 ◽  
Vol 20 (14) ◽  
pp. 1235-1239 ◽  
Author(s):  
Zoltán Petykó ◽  
Attila Tóth ◽  
Imre Szabó ◽  
Rita Gálosi ◽  
László Lénárd

2009 ◽  
Vol 3 (3) ◽  
pp. 232-243
Author(s):  
Anthony Ferreira ◽  
Fernando Perez-Diaz ◽  
Charles Cohen-Salmon

Human studies suggest the existence of an exercise dependency syndrome and a link between drug intake and intense physical activity. Our aim was to assess whether a link actually existed between running activity and cocaine intake in mice. Thirty male Swiss mice were used. Ten mice were used as controls, individually housed in cages without a wheel, and 20 mice were in cages with free access to a running wheel. Cocaine preference was estimated as the ratio (as percent) of cocaine solution intake over total fuid intake in the course of free oral access to cocaine solution versus water. High cocaine scores were only found with high wheel activity. The lowest activity scores were found with low cocaine preference. A group of “high runners” impervious to cocaine appetence and to the effects of exercise withdrawal were found, which may suggest that shared mechanisms could be involved in both dependence on sport and drug taking. Findings suggest that moderate activity seems to be associated with low cocaine preference, and cocaine intake could increase in cases of intense activity. The urge for physical activity (as seen with top-level professional athletes) may theoretically combine with different degrees of vulnerability to cocaine. The use of substances by those engaging in intense physical activity, for performance enhancement or recreational purposes, could potentially trigger a pattern of consumption and addiction. This pattern corresponds with the theory that there may be an addictive element in physical activity. Animal models could prove useful for identifying biological or behavioral predictors of such vulnerability and identifying persons either at risk or possessing resistance.


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