The combination of body composition conditions and systemic inflammation markers has prognostic value for patients with gastric cancer treated with adjuvant chemoradiotherapy

Nutrition ◽  
2021 ◽  
pp. 111464
Author(s):  
Yi Li ◽  
Wen-bo Wang ◽  
Lei Yang ◽  
Qing-yun Wang ◽  
Jing Dai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Composition ◽  
Systemic Inflammation ◽  
Prognostic Value ◽  
Adjuvant Chemoradiotherapy ◽  
Inflammation Markers

scholarly journals Does the Severity of Obstructive Sleep Apnea Have an Independent Impact on Systemic Inflammation?

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 292
Author(s):  
Romana Suša ◽  
Vojislav Ćupurdija ◽  
Ljiljana Novković ◽  
Miloš Ratinac ◽  
Slobodan Janković ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Nutritional Status ◽  
Body Mass ◽  
Systemic Inflammation ◽  
Body Fat Percentage ◽  
Inflammation Markers ◽  
Fat Percentage ◽  
Obstructive Sleep ◽  
Tnf Α

Background and Objectives: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. Materials and Methods: In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea–hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). Results: We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI (r = 0.633, p < 0.001), as well as with body fat percentage (r = 0.450, p = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) (r = 0.579, p = 0.003) and lean body mass (r = −0.501, p = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. Conclusions: Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA.

scholarly journals Loss of ARID1A Expression is Associated with Systemic Inflammation Markers and has Important Prognostic Significance in Gastric Cancer.

2021 ◽  
Author(s):  
Xuan Wang ◽  
Keying Che ◽  
Tao Shi ◽  
Qin Liu ◽  
Xinyun Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Systemic Inflammation ◽  
Prognostic Significance ◽  
Suppressor Gene ◽  
Albumin Level ◽  
Inflammation Markers ◽  
Ffpe Tumor ◽  
Cox Analysis ◽  
Low Expression

Abstract Background: The tumor suppressor gene AT-rich interactive domain 1A (ARID1A) and systemic inflammatory response (SIR) have been reported to be related to the sensitivity of immunotherapy. This study intended to explore the relationship between ARID1A expression and SIR, and to further elucidate the prognostic value of ARID1A expression in gastric cancer (GC).Methods: The mRNA and protein expression of ARID1A were detected in 272 formalin-fixed paraffin-embedded (FFPE) tumor tissues. The data of nine systemic inflammation markers were collected one week before gastrectomy. Univariate and multivariate COX analysis were used to screen out independent predictors of GC.Results: Negative expression of ARID1A protein was related to GC with microsatellite instability-high (MSI-H) (p=0.033), positive programmed cell death-ligand 1 (PD-L1) (p=0.005) and lower albumin level (p=0.0064). Low expression of ARID1A mRNA was common in GC with abnormal E-cadherin (p=0.020) and higher platelet/lymphocyte ratio (PLR) (p=0.0391). Multivariate COX analysis showed that the expression of ARID1A protein (p=0.023), age (p=0.004), T stage (p=0.009) and N stage (p=0.009) were independent predictors of GC. The nomogram established by independent predictors can accurately evaluate the survival risk of patients with GC.Conclusions: The loss of ARID1A protein expression was associated with MSI-H subtype and high expression of PD-L1 in GC. Negative ARID1A protein and low expression of mRNA were associated with aberrant systemic inflammatory markers. Expression of ARID1A protein had important prognostic significance in GC.

scholarly journals Prognostic Value and Association of Sarcopenia and Systemic Inflammation for Patients with Gastric Cancer Following Radical Gastrectomy

2019 ◽  
Vol 24 (11) ◽  
Author(s):  
Jian‐Xian Lin ◽  
Jun‐Peng Lin ◽  
Jian‐Wei Xie ◽  
Jia‐bin Wang ◽  
Jun Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systemic Inflammation ◽  
Prognostic Value ◽  
Radical Gastrectomy

scholarly journals 1225P The prognostic value of textural features of primary tumour and systemic inflammation markers in NSCLC

2020 ◽  
Vol 31 ◽  
pp. S798
Author(s):  
U. Aydos ◽  
O. Sutcuoglu ◽  
U.O. Akdemir ◽  
O. Yazıcı ◽  
L.O. Atay
Keyword(s):  
Systemic Inflammation ◽  
Prognostic Value ◽  
Primary Tumour ◽  
Textural Features ◽  
Inflammation Markers

The Prognostic Value of the Perioperative Systemic Inflammation Score for Patients With Advanced Gastric Cancer

2020 ◽  
Vol 40 (3) ◽  
pp. 1503-1512
Author(s):  
KENTARO HARA ◽  
TORU AOYAMA ◽  
TAKANOBU YAMADA ◽  
MASATO NAKAZONO ◽  
SHINSUKE NAGASAWA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Systemic Inflammation ◽  
Prognostic Value ◽  
Systemic Inflammation Score ◽  
Inflammation Score

scholarly journals Distinctive Prognostic Value and Cellular Functions of Osteopontin Splice Variants in Human Gastric Cancer

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1820
Author(s):  
Chengcheng Hao ◽  
Yuxin Cui ◽  
Jane Lane ◽  
Shuqin Jia ◽  
Jiafu Ji ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Prognostic Value ◽  
Splice Variants ◽  
Tnm Staging ◽  
Migration And Invasion ◽  
Ros Production ◽  
Gastric Cancer Cells ◽  
Normal Tissues

Background: Osteopontin (OPN) splice variants are identified as predictors of tumour progression and therapeutic resistance in certain types of solid tumours. However, their roles in gastric cancer (GC) remain poorly characterized. The current study sought to assess the prognostic value of the three OPN splice variants (namely OPN-a, OPN-b, and OPN-c) in gastric cancer and their potential functions within gastric cancer cells. Methods: RNA extraction and reverse transcription were performed using our clinical cohort of gastric carcinomas and matched normal tissues (n = 324 matched pairs). Transcript levels were determined using real-time quantitative PCR. Three OPN splice variants overexpressed cell lines were created from the gastric cancer cell line HGC-27. Subsequently, biological functions, including cell growth, adhesion, migration, and invasion, were studied. The potential effects of OPN isoforms on cisplatin and 5-Fu were evaluated by detecting cellular reactive oxygen species (ROS) levels in the HGC-27-derived cell lines. Results: Compared with normal tissues, the expression levels of three splice variants were all elevated in gastric cancer tissues in an order of OPN-a > OPN-b > OPN-c. The OPN-a level significantly increased with increasing TNM staging and worse clinical outcome. There appeared to be a downregulation for OPN-c in increasing lymph node status (p < 0.05), increasing TNM staging, and poor differentiation. High levels of OPN-a and OPN-b were correlated with short overall survival and disease-free survival of gastric cancer patients. However, the low expression of OPN-c was significantly associated with a poor prognosis. Functional analyses further showed that ectopic expression of OPN-c suppressed in vitro proliferation, adhesiveness, migration, and invasion properties of HGC-27 cells, while the opposite role was seen for OPN-a. Cellular ROS detection indicated that OPN-a and OPN-c significantly promoted ROS production after treatment with 5-Fu comparing to OPN-vector, while only OPN-a markedly induced ROS production after treatment with cisplatin. Conclusion: Our results suggest that OPN splice variants have distinguished potential to predict the prognosis of gastric cancer. Three OPN variants exert distinctive functions in gastric cancer cells. Focusing on specific OPN isoforms could be a novel direction for developing diagnostic and therapeutic approaches in gastric cancer.

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