scholarly journals Association of serum vitamin D status with development of type 2 diabetes: A retrospective cross-sectional study

2021 ◽  
Vol 36 ◽  
pp. 1-13
Author(s):  
Hannah Marcus ◽  
Muralidhar Varma ◽  
Sonal Sekhar M
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D

scholarly journals Dietary Magnesium Intake Affects the Association Between Serum Vitamin D and Type 2 Diabetes: A Cross-Sectional Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Weichao Huang ◽  
Xiaoman Ma ◽  
Hualiang Liang ◽  
Haojia Li ◽  
Jiayu Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Magnesium Intake ◽  
Serum Vitamin D ◽  
Low Magnesium ◽  
Dietary Magnesium

Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also been reported to be associated with lower T2D risk. Besides, magnesium is an essential cofactor for vitamin D activation. However, the effect of dietary magnesium intake on the association between vitamin D and the risk of T2D has not been studied comprehensively. Therefore, we designed this cross-sectional study to assess the effect modification of magnesium intake on the association between vitamin D and risk of T2D.Research Design and Methods: The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuously from 2007 to 2014, involving 10,249 participants. By having stratified participants based on magnesium intake category (low magnesium intake <267 mg/day; high magnesium intake: ≥267 mg/day), we further evaluated the difference (interaction test) between the relationship of vitamin D with the risk of T2D among low magnesium intake participants and high magnesium intake participants using weighted multivariable logistic regression.Results: In this cross-sectional study, the association of serum vitamin D with the incidence of T2D appeared to differ between the low magnesium intake group and the high magnesium intake group (OR: 0.968, 95%Cl: 0.919–1.02 vs. OR: 0.925, 95%Cl: 0.883–0.97). Furthermore, there was evidence of interaction between vitamin D levels and magnesium intake on decreasing the incidence of T2D (p-value for interaction = 0.001).Conclusions: The results of our study indicated that magnesium intake might affect the association of serum vitamin D with the risk of T2D. Such a finding requires further randomized controlled trials to provide more evidence.

scholarly journals Vitamin D Status and Its Relationship with Metabolic Markers in Persons with Obesity and Type 2 Diabetes in the UAE: A Cross-Sectional Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Amena Sadiya ◽  
Solafa M. Ahmed ◽  
Sijomol Skaria ◽  
Salah Abusnana
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Vitamin D ◽  
Waist Circumference ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Glycemic Profile

Aim.To report vitamin D status and its impact on metabolic parameters in people in the United Arab Emirates with obesity and type 2 diabetes (T2D).Methodology.This cross-sectional study included 309 individuals with obesity and T2D who were randomly selected based on study criteria. Serum concentrations of 25-hydroxy vitamin D (s-25(OH)D), calcium, phosphorus, parathyroid hormone, alkaline phosphatase, glycemic profile, and cardiometabolic parameters were assessed in fasting blood samples, and anthropometric measurements were recorded.Results.Vitamin D deficiency (s-25(OH)D < 50 nmol/L) was observed in 83.2% of the participants, with a mean s-25(OH)D of 33.8 ± 20.3 nmol/L. Serum 25(OH)D correlated negatively (P<0.01) with body mass index, fat mass, waist circumference, parathyroid hormone, alkaline phosphatase, triglycerides, LDL-cholesterol, and apolipoprotein B and positively (P<0.01) with age and calcium concentration. Waist circumference was the main predictor of s-25(OH)D status. There was no significant association between serum 25(OH)D and glycemic profile.Conclusion.There is an overwhelming prevalence of vitamin D deficiency in our sample of the Emirati population with obesity and T2D. Association of s-25(OH)D with body mass index, waist circumference, fat mass, markers of calcium homeostasis and cardiometabolic parameters suggests a role of vitamin D in the development of cardiometabolic disease-related process.

scholarly journals A high prevalence of prediabetes and vitamin D deficiency are more closely associated in women: results of a cross-sectional study

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110333
Author(s):  
Jeonghun Lee ◽  
Young Joo Lee ◽  
Youngsun Kim
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Metabolic Characteristics ◽  
High Prevalence

Objective Many studies have shown that vitamin D deficiency is associated with insulin resistance and metabolic syndrome. However, few studies have shown independent associations between vitamin D deficiency and the metabolic characteristics of prediabetes. We aimed to evaluate the relationship between serum vitamin D concentration and metabolic risk factors in adults with prediabetes. Methods We enrolled 161 patients aged 25 to 75 years in a cross-sectional study and collected clinical and biochemical data, including 25-hydroxyvitamin D (25[OH]D) status and fasting glucose concentration. Vitamin D status was defined as follows: deficiency (25[OH]D <49.9 ng/mL), insufficiency (49.9 to 74.9 nmol/L) or sufficiency (>74.9 nmol/L). Prediabetes was defined using fasting plasma glucose concentrations of 5.55 to 6.49 mmol/L. Results The prevalences of vitamin D deficiency and insufficiency were 49.7% and 24.8%, respectively. Participants with vitamin D deficiency had a higher prevalence of prediabetes than those without (53.8% vs. 32.1%), and there was a significant relationship between female sex and vitamin D status (odds ratio: 1.382; 95% confidence interval: 0.335–5.693). Conclusion Vitamin D deficiency is more closely associated with a high prevalence of prediabetes in women than in men. Further studies are needed to elucidate the explanation for this association.

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