scholarly journals Repression of proinflammatory gene expression by lipid extract of Nostoc commune var sphaeroides Kützing, a blue-green alga, via inhibition of nuclear factor-κB in RAW 264.7 macrophages

2008 ◽  
Vol 28 (2) ◽  
pp. 83-91 ◽  
Author(s):  
Young-Ki Park ◽  
Heather E. Rasmussen ◽  
Sarah J. Ehlers ◽  
Kara R. Blobaum ◽  
Fan Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Green Alga ◽  
Nuclear Factor Κb ◽  
Raw 264.7 ◽  
Nuclear Factor ◽  
Blue Green Alga ◽  
Nostoc Commune ◽  
Raw 264.7 Macrophages ◽  
Proinflammatory Gene ◽  
Proinflammatory Gene Expression

scholarly journals Essential oil from halophyte Lobularia maritima: protective effects against CCl4-induced hepatic oxidative damage in rats and inhibition of the production of proinflammatory gene expression by lipopolysaccharide-stimulated RAW 264.7 macrophages

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 36758-36770 ◽  
Author(s):  
Anis Ben Hsouna ◽  
Sabah Dhibi ◽  
Wissal Dhifi ◽  
Rania Ben Saad ◽  
Faical Brini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Essential Oil ◽  
Raw 264.7 ◽  
Protective Effects ◽  
Raw 264.7 Macrophages ◽  
Chemical Profiling ◽  
Proinflammatory Gene ◽  
Lobularia Maritima ◽  
Proinflammatory Gene Expression

The present study evaluates the chemical profiling of the essential oil of a halophyte, L. maritima (LmEO), and its protective potential against CCl4-induced oxidative stress in rats.

Nuclear factor-κB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency

2002 ◽  
Vol 32 (9) ◽  
pp. 890-897 ◽  
Author(s):  
Faith Zamamiri-Davis ◽  
Ying Lu ◽  
Jerry T Thompson ◽  
K.Sandeep Prabhu ◽  
Padala V Reddy ◽  
...  
Keyword(s):  
Selenium Deficiency ◽  
Nuclear Factor Κb ◽  
Cyclooxygenase 2 ◽  
Raw 264.7 ◽  
Nuclear Factor ◽  
Raw 264.7 Macrophages ◽  
Over Expression

scholarly journals Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Science ◽  
2018 ◽  
Vol 362 (6416) ◽  
pp. 834-839 ◽  
Author(s):  
Torkild Visnes ◽  
Armando Cázares-Körner ◽  
Wenjing Hao ◽  
Olov Wallner ◽  
Geoffrey Masuyer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Cell ◽  
Nuclear Factor Κb ◽  
Cell Recruitment ◽  
Inflammatory Conditions ◽  
Molecule Inhibitor ◽  
Proinflammatory Gene ◽  
Factor Α ◽  
Proinflammatory Gene Expression

The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. TH5487 prevents tumor necrosis factor–α–induced OGG1-DNA interactions at guanine-rich promoters of proinflammatory genes. This, in turn, decreases DNA occupancy of nuclear factor κB and proinflammatory gene expression, resulting in decreased immune cell recruitment to mouse lungs. Thus, we present a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo.

Nuclear Factor of Activated T Cell Mediates Proinflammatory Gene Expression in Response to Mechanotransduction

2007 ◽  
Vol 1117 (1) ◽  
pp. 138-142 ◽  
Author(s):  
A. B. CELIL AYDEMIR ◽  
S. LEE ◽  
D. WON KIM ◽  
T. R. GARDNER ◽  
D. PRINCE ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Nuclear Factor ◽  
Activated T Cell ◽  
Proinflammatory Gene ◽  
Proinflammatory Gene Expression
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