scholarly journals Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma

Oral Oncology ◽  
2013 ◽  
Vol 49 (11) ◽  
pp. 1059-1066 ◽  
Author(s):  
Kristy A. Warner ◽  
April Adams ◽  
Lisiane Bernardi ◽  
Carolina Nor ◽  
Kelsey A. Finkel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Lines ◽  
Mucoepidermoid Carcinoma ◽  
Node Metastasis ◽  
Tumorigenic Cell

scholarly journals Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Xuting Xu ◽  
Dong Li ◽  
Jin Liu ◽  
Zhihong Ma ◽  
Huilian Huang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Suppressor ◽  
Cell Lines ◽  
Western Blotting ◽  
Invasion And Migration ◽  
Node Metastasis ◽  
Proliferation And Metastasis ◽  
And Migration

Objective. The receptor-type tyrosine-protein phosphatase κ (PTPRK) is a candidate tumor suppressor involved in the tumorigenesis of various organs. However, its expression and biological roles in non-small-cell lung cancer (NSCLC) have not yet been investigated. Methods. PTPRK expression in NSCLC tissues and cell lines was examined using real-time PCR and western blotting. In addition, the effects of PTPRK on cell migration, invasion, and proliferation were evaluated in vitro. Furthermore, we explored whether the downregulation of PTPRK led to STAT3 activation in NSCLC cell lines by western blotting. The expression of phospho-STAT3Tyr705 in primary human NSCLC tissues was evaluated by immunohistochemistry. Results. The results showed that PTPRK expression was frequently reduced in NSCLC tissues with lymph node metastasis and cell lines. The inhibition of PTPRK expression resulted in increased proliferation, invasion, and migration of NSCLC cells in vitro. Additionally, after silencing of PTPRK, phospho-STAT3Tyr705 was significantly increased in NSCLC cells. Moreover, the phospho-STAT3Tyr705 levels of NSCLC tissues were positively correlated with lymph node metastasis and significantly inversely correlated with the expression of PTPRK (p<0.05). Conclusions. These results suggested that PTPRK functions as a novel tumor suppressor in NSCLC, and its suppressive ability may be involved in STAT3 activation.

scholarly journals Effects of Concentrated Growth Factor and Cervical Lymph Node Metastasis on the Prognosis of Mucoepidermoid Carcinoma of the Parotid Gland

2020 ◽  
Vol 4 (1) ◽  
pp. 45-50
Author(s):  
Shang-Zhi Han ◽  
Xin Lv ◽  
Xi-Bo Chen ◽  
Ying-Ying Xu ◽  
Rui Liu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Survival Rate ◽  
Lymph Node Metastasis ◽  
Parotid Gland ◽  
Distant Metastasis ◽  
Mucoepidermoid Carcinoma ◽  
Cervical Lymph Node Metastasis ◽  
Pathological Grade ◽  
Node Metastasis ◽  
Independent Risk Factors

Introduction: Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy. As studies reported on large cases of mucoepidermoid carcinoma of the parotid glands are few, this paper aims to research the effects of clinical and pathological factors, such as applying concentrated growth factor (CGF) on repairing and cervical lymph node metastasis, on the prognosis of mucoepidermoid carcinoma of the parotid gland. Methods: The retrospective analysis of prognostic factors was conducted based on 176 cases with mucoepidermoidcarcinoma of the parotid gland, who received treatment at the Affiliated Hospital of  Chengde Medical College during the period of March 2000 to March 2012. Results: The Five-year overall survival rate was 75.57%, while the Five-year tumor-free survival rate was 64.77%. Univariate analysis showed that the influential factors for the prognosis of mucoepidermoid carcinoma of the parotid gland included surgical approach, tumor size, clinical stage, pathological grade, lymph node metastasis, and distant metastasis, etc; among which pathological grade, lymph node metastasis, and distant metastasis were indicated by multivariate analysis to be the independent risk factors. Conclusion: The survival rate of mucoepidermoid carcinoma of the parotid gland is relatively high. Lymph node metastasis, pathological grade, and distant metastasis are the independent risk factors that affect the prognosis of patients with mucous epidermis carcinoma of the parotid gland.

scholarly journals Cytogenetic, genomic, and epigenetic characterization of the HSC-3 tongue cell line with lymph node metastasis

2018 ◽  
Vol 60 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Ilda P. Ribeiro ◽  
Joana M. Rodrigues ◽  
Alexandra Mascarenhas ◽  
Nadezda Kosyakova ◽  
Francisco Caramelo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Line ◽  
Node Metastasis

scholarly journals Rapid metastasis of stage IA primary pulmonary high-grade mucoepidermoid carcinoma with a cystic airspace: a case report and reflection

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110381
Author(s):  
Yi Chen ◽  
Fangbiao Zhang ◽  
Xiaomei Chen ◽  
Liping Yan ◽  
Xiangyan Zhang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Surgical Resection ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Left Lung ◽  
High Grade ◽  
Early Metastasis ◽  
Node Metastasis ◽  
Stage Ia

Primary pulmonary high-grade mucoepidermoid carcinoma (MEC) with a cystic airspace is uncommon, and early metastasis is extremely rare. In such cases, however, it is clinically important for clinicians to consider whether the tumor has spread to the lymph nodes through the cystic airspace. A 77-year-old man presented to our hospital with cough and hemoptysis. Chest computed tomography showed a 25-mm-diameter mass with a cystic airspace located in the upper lobe of the left lung. The possibility of malignancy was considered. Without a definitive preoperative diagnosis, left upper lobectomy and mediastinal lymphadenectomy were performed. Histopathological examination revealed the typical histological characteristics of high-grade MEC (stage IA) and no lymph node metastasis. However, lymph node metastasis was found 6 months after surgical resection, and radiochemotherapy was performed. The patient developed widespread metastatic disease 4 months following completion of radiochemotherapy and died 2 months later. Primary pulmonary MEC with a cystic airspace is a rare malignant disease with uncommon imaging findings. Complete surgical resection is the main treatment method for high-grade MEC. In this case, we hypothesize that early metastasis was caused by seeding of tumor cells through the cystic airspace.

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