Change in waist circumference and the progression of subclinical atherosclerosis in type 2 diabetes patients

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity. Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B12 (n = 12) were retrospectively evaluated. Body weight, waist circumference, hemoglobin A1c (HbA1c), blood pressure, liver function, serum lipids, and serum uric acid were assessed before and 6 months after the treatment. Results: Mexiletine significantly decreased body weight and waist circumference. The changes in body weight and waist circumference in 6 months in the mexiletine group were greater than in the control group. In metabolic parameters, there were significant decreases in triglyceride (TG) and serum uric acid. There were positive relationships between the change in body weight and the changes in TG, uric acid, alanine aminotransferase (ALT), and HbA1c. Conclusions: Mexiletine may affect body weight regulation. It ameliorated the metabolic parameters possibly by decreasing visceral fat. Further study should be performed to clarify the mechanism of the effect.

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Letter: Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetes Patients (Diabetes Metab J 2011;35:41-9)

Diabetes & Metabolism Journal ◽

10.4093/dmj.2011.35.2.188 ◽

2011 ◽

Vol 35 (2) ◽

pp. 188

Author(s):

Min Suk Lee ◽

Hae Jin Kim

Keyword(s):

Type 2 Diabetes ◽

Subclinical Atherosclerosis ◽

Surrogate Marker ◽

C Peptide ◽

Peptide Level ◽

Diabetes Patients

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Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study

Journal of Translational Medicine ◽

10.1186/s12967-016-1020-8 ◽

2016 ◽

Vol 14 (1) ◽

Cited By ~ 27

Author(s):

Shuang Zheng ◽

Sheng Shi ◽

Xingxing Ren ◽

Tingting Han ◽

Yangxue Li ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cohort Study ◽

Waist Circumference ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cross Sectional ◽

First Degree Relatives ◽

Diabetes Patients

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Neck circumference and waist circumference associated with cardiovascular events in type 2 diabetes (Beijing Community Diabetes Study 23)

Scientific Reports ◽

10.1038/s41598-021-88927-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Guang-Ran Yang ◽

Ming-Xia Yuan ◽

Gang Wan ◽

Xue-Lian Zhang ◽

Han-Jing Fu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Waist Circumference ◽

Community Health ◽

Cardiovascular Events ◽

Community Health Centers ◽

Neck Circumference ◽

Health Centers ◽

Diabetes Patients

AbstractObesity increases the risk of developing cardiovascular disease and other metabolic diseases. We intended to compare three different anthropometric indicators of obesity, in predicting the incidence of cardiovascular events in Chinese type 2 diabetes. Beijing Community Diabetes Study was a prospective multi-center study conducted in Beijing community health centers. Type 2 diabetes patients from fourteen community health centers were enrolled at baseline. The primary endpoint was cardiovascular events. The upper quartile of neck circumference (NC) was set as greater NC. A total of 3299 diabetes patients were enrolled. In which, 941 (28.52%) had cardiovascular disease at baseline. Logistic analysis showed that central obesity (waist circumference (WC) above 90 cm in men and 85 cm in women) and greater NC were all related to baseline cardiovascular disease (adjusted OR = 1.49, and 1.55). After 10-year follow-up, 340 (10.31%) had cardiovascular events. Compared with patients without cardiovascular events, those having cardiovascular events had higher BMI, larger WC and NC. Cox regression analysis showed that greater WC and NC were all associated with the occurrence of cardiovascular events (adjusted HR = 1.41, and 1.38). A higher NC and WC might increase the risk of cardiovascular events by about 40% in type 2 diabetes patients in Beijing communities.

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The Relationship between Hypertriglyceridemic Waist Phenotype and Early Diabetic Nephropathy in Type 2 Diabetes

Cardiorenal Medicine ◽

10.1159/000477828 ◽

2017 ◽

Vol 7 (4) ◽

pp. 295-300 ◽

Cited By ~ 8

Author(s):

Chun-Ming Ma ◽

Rui Wang ◽

Xiao-Li Liu ◽

Na Lu ◽

Qiang Lu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Waist Circumference ◽

Glycosylated Hemoglobin ◽

Serum Triglyceride ◽

Hypertriglyceridemic Waist ◽

The Relationship ◽

Early Diabetic Nephropathy ◽

Diabetes Patients

Background/Aims: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. Methods: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). Results: The prevalence of the HW phenotype was 34.9%. The prevalence of early diabetic nephropathy was 10.6% in type 2 diabetes patients with normal waist circumference and triglycerides and 24.5% in type 2 diabetes patients with HW phenotype. After adjustment for sex, age, body mass index, hypertension, history of diabetes, and glycosylated hemoglobin A1c, the prevalence of early diabetic nephropathy among type 2 diabetes patients with the HW phenotype was 2.81 (95% confidence interval 1.36-5.80, p = 0.005) times higher than that among type 2 diabetes patients with normal waist circumference and triglycerides. Conclusion: There was a significant correlation between HW phenotype and early diabetic nephropathy in type 2 diabetes.

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