Metabolic effects of access to 10% sucrose solution in female rats and transmission of some effects to their offspring

A single 1 mg dose of crystalline dihydrotachysterol was administered by gavage to female rats. Quantitative studies of subsequent changes in serum calcium level, food intake, animal weight, and femur cortical fragility indicated that the effects of this drug were severe and protracted. Serum calcium concentration increased to a peak within 2 days and remained elevated throughout the experiment. Food intake and weight of dihydrotachysterol-treated animals declined severely and a sudden onset of femur cortical fragility was detected on the 5th day following treatment.

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Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.06.035 ◽

2021 ◽

Vol 11 (6) ◽

pp. 320-334

Author(s):

Myroslava Hrytsak ◽

Daria Popovych ◽

Nataliya Badiuk ◽

Ivanna Hrytsan ◽

Walery Zukow

Keyword(s):

Tap Water ◽

Physiological Activity ◽

Experimental Studies ◽

Mineral Waters ◽

Female Rats ◽

Metabolic Effects ◽

Control Group ◽

Healthy Female ◽

Sodium Magnesium ◽

Female Wistar Rats

Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water.

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Modulation of the hepatic expression of miR-33 and miR-34a possibly mediates the metabolic effects of estrogen in ovariectomized female rats

European Journal of Pharmacology ◽

10.1016/j.ejphar.2020.173006 ◽

2020 ◽

Vol 873 ◽

pp. 173006

Author(s):

Mennatallah A. Ali ◽

Maher A. Kamel

Keyword(s):

Female Rats ◽

Metabolic Effects ◽

Hepatic Expression

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Behavioral and metabolic effects of peripherally administered Olanzapine and Topiramate in male and female rats

Appetite ◽

10.1016/j.appet.2009.04.068 ◽

2009 ◽

Vol 52 (3) ◽

pp. 830

Author(s):

S.S. Evers ◽

F. Calcagnoli ◽

G. Van Dijk ◽

A.J.W. Scheurink

Keyword(s):

Female Rats ◽

Metabolic Effects ◽

Male And Female ◽

Male And Female Rats

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Effects of intestinal bypass surgery on appetite, food intake, and body weight in obese and lean rats.

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1978.234.4.e389 ◽

1978 ◽

Vol 234 (4) ◽

pp. E389 ◽

Cited By ~ 1

Author(s):

A Sclafani ◽

H S Koopmans ◽

J R Vasselli ◽

M Reichman

Keyword(s):

Body Weight ◽

Food Intake ◽

Bypass Surgery ◽

Sucrose Solution ◽

Caloric Intake ◽

Jejunoileal Bypass ◽

The Body ◽

Female Rats ◽

Intestinal Bypass ◽

Clinical Observations

Jejunoileal bypass surgery or sham surgery was performed in female rats made obese with ventromedial hypothalamic (VMH) knife cuts, and in lean control rats. After bypass surgery, the VMH rats underate and lost weight until they reached the body weight of the control sham rats, and they then maintained their weight at control levels. Bypass surgery in lean rats produced much smaller reductions in food intake and body weight. Both bypass groups initially consumed less of a sucrose solution and milk diet during 1 h/day tests, but their intakes returned to near normal levels during the second postoperative month. Reconnection of the intestinal tract in the VMH-bypass rats led to renewed hyperphagia and return to obese body weights. A second experiment revealed that bypass surgery reduces food intake and body weight in genetically obese (fatty) rats, but this effect is not as pronounced as that displayed by VMH rats. These results confirm recent clinical observations that reduced appetite and caloric intake are the major causes of the weight loss produced by intestinal bypass surgery.

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Differential Cerebral Gustatory Responses to Sucrose, Aspartame, and Stevia Using Gustatory Evoked Potentials in Humans

Nutrients ◽

10.3390/nu12020322 ◽

2020 ◽

Vol 12 (2) ◽

pp. 322 ◽

Cited By ~ 1

Author(s):

Thomas Mouillot ◽

Anaïs Parise ◽

Camille Greco ◽

Sophie Barthet ◽

Marie-Claude Brindisi ◽

...

Keyword(s):

Evoked Potentials ◽

Neural Plasticity ◽

Sucrose Solution ◽

Taste Perception ◽

Metabolic Effects ◽

Synaptic Connections ◽

Analog Scale ◽

Three Solutions ◽

Cerebral Activation ◽

Evoked Potentials In Humans

Aspartame and Stevia are widely substituted for sugar. Little is known about cerebral activation in response to low-caloric sweeteners in comparison with high-caloric sugar, whereas these molecules lead to different metabolic effects. We aimed to compare gustatory evoked potentials (GEPs) obtained in response to sucrose solution in young, healthy subjects, with GEPs obtained in response to aspartame and Stevia. Twenty healthy volunteers were randomly stimulated with three solutions of similar intensities of sweetness: Sucrose 10 g/100 mL of water, aspartame 0.05 g/100 mL, and Stevia 0.03 g/100 mL. GEPs were recorded with EEG (Electroencephalogram) electrodes. Hedonic values of each solution were evaluated using the visual analog scale (VAS). The main result was that P1 latencies of GEPs were significantly shorter when subjects were stimulated by the sucrose solution than when they were stimulated by either the aspartame or the Stevia one. P1 latencies were also significantly shorter when subjects were stimulated by the aspartame solution than the Stevia one. No significant correlation was noted between GEP parameters and hedonic values marked by VAS. Although sucrose, aspartame, and Stevia lead to the same taste perception, cerebral activation by these three sweet solutions are different according to GEPs recording. Besides differences of taste receptors and cerebral areas activated by these substances, neural plasticity, and change in synaptic connections related to sweet innate preference and sweet conditioning, could be the best hypothesis to explain the differences in cerebral gustatory processing after sucrose and sweeteners activation.

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