scholarly journals G-protein Coupled Receptor 34 Knockdown Impairs the Proliferation and Migration of HGC-27 Gastric Cancer Cells In Vitro

2015 ◽  
Vol 128 (4) ◽  
pp. 545-549 ◽  
Author(s):  
Zhong-Tian Jin ◽  
Kun Li ◽  
Mei Li ◽  
Zhi-Gang Ren ◽  
Fu-Shun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
G Protein Coupled ◽  
Proliferation And Migration

scholarly journals Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells

2004 ◽  
Vol 95 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Shun-ichiro Okumura ◽  
Hiroko Baba ◽  
Tatsuro Kumada ◽  
Koji Nanmoku ◽  
Hirofumi Nakajima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Gastric Cancer Cells ◽  
Nih3t3 Cells ◽  
G Protein Coupled

scholarly journals Myrrh induces the apoptosis and inhibits the proliferation and migration of gastric cancer cells through down-regulating cyclooxygenase-2 expression

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Mengxue Sun ◽  
Jie Hua ◽  
Gaoshuang Liu ◽  
Peiyun Huang ◽  
Ningsheng Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cellular Proliferation ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cox 2 ◽  
And Migration ◽  
Proliferation And Migration

Abstract Objective: The present study is designed to evaluate the anti-tumor effects of myrrh on human gastric cancer both in vitro and in vivo. Methods: The gastric cancer cell proliferation was determined by MTT assay. Apoptosis was measured by flow cytometry and Hoechst 33342 staining. Wound healing was performed to evaluate the effects of myrrh on the migration. COX-2, PCNA, Bcl-2, and Bax expressions were detected by Western blot analysis. A xenograft nude mice model of human gastric cancer was established to evaluate the anti-cancer effect of myrrh in vivo. Results: Myrrh significantly inhibited cellular proliferation, migration, and induced apoptosis in vitro as well as inhibited tumor growth in vivo. In addition, myrrh inhibited the expression of PCNA, COX-2, and Bcl-2 as well as increased Bax expression in gastric cancer cells. Conclusion: Myrrh may inhibit the proliferation and migration of gastric cancer cells, as well as induced their apoptosis by down-regulating the expression of COX-2.

Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression

2020 ◽  
Vol 216 (6) ◽  
pp. 152986
Author(s):  
Shuai-Shuai Shi ◽  
Hui-Peng Zhang ◽  
Chang-Qing Yang ◽  
Li-Na Li ◽  
Yu Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Mengting Yang ◽  
Meng Jin ◽  
Kailong Li ◽  
Haifeng Liu ◽  
Xiaxia Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Necrosis Factor Receptor ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition ◽  
In The Wild ◽  
And Migration ◽  
Exact Effect ◽  
Proliferation And Migration

Gastric cancer is the third most common type of tumor associated with death. TRAF6 belongs to the tumor necrosis factor receptor-associated factor family and has been demonstrated to be involved in tumor progression in various cancers. However, the exact effect of TRAF6 on gastric cancer stem cells has not been extensively studied. In this study, abnormal expression of TRAF6 was found in gastric cancer tissues. Overexpression of TRAF6 enhanced proliferation and migration, and TRAF6 knockdown reversed this phenomenon in gastric cancer cells. Moreover, TRAF6 may inhibit differentiation and promote stemness and epithelial-mesenchymal transition (EMT). Transcriptome profiles revealed 701 differentially expressed genes in the wild-type group and the TRAF6 knockout group. Potential molecules associated with cell proliferation and migration were identified, including MAPK, FOXO, and IL-17. In conclusion, TRAF6 is a significant factor promoting proliferation and migration in gastric cancer cells and may provide a new target for the accurate treatment of gastric cancer.

RUNX3-mediated up-regulation of miR-29b suppresses the proliferation and migration of gastric cancer cells by targeting KDM2A

2016 ◽  
Vol 381 (1) ◽  
pp. 138-148 ◽  
Author(s):  
Ye Kong ◽  
Shuiyan Zou ◽  
Fenghua Yang ◽  
Xia Xu ◽  
Wenhong Bu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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