scholarly journals Ewing sarcoma of urinary bladder occurring simultaneously with high grade papillary urothelial carcinoma

Pathology ◽  
2020 ◽  
Vol 52 (5) ◽  
pp. 612-615
Author(s):  
Hui-Zhi Zhang ◽  
Su-Ying Wang ◽  
Xiao-Han Shen
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Ewing Sarcoma ◽  
High Grade ◽  
Papillary Urothelial Carcinoma

Dermatomyositis in a patient with high grade papillary urothelial carcinoma of urinary bladder

2007 ◽  
Vol 10 (2) ◽  
pp. 153-155
Author(s):  
Aman SHARMA ◽  
Susheel KUMAR ◽  
Ajay WANCHU ◽  
A. K. MANDAL ◽  
Surjit SINGH ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
High Grade ◽  
Papillary Urothelial Carcinoma

scholarly journals Incidence of various urothelial malignancy in patients undergoing transurethral resection of bladder tumour in tertiary care hospital

2020 ◽  
Vol 8 (1) ◽  
pp. 346
Author(s):  
Kamal Preet Kaur ◽  
Gurpreet Singh Bhangu ◽  
Darpan Bansal ◽  
Divya Julka
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Transurethral Resection ◽  
Bladder Tumor ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
High Grade ◽  
Urothelial Malignancy ◽  
Papillary Urothelial Carcinoma

Background: Urinary bladder lesions are a great health concern as it lies among the top ten most common cancers in the world. These range from benign, harmless lesions that do not recur to life threatening tumors. The present study was undertaken to study incidence of various urothelial cancer in patients undergoing transurethral resection of bladder tumor in tertiary care hospital, as the treatment, follow up and prognosis is highly variable with different subtypes of bladder cancer.Methods: A hospital based descriptive cross-sectional study was conducted on all patients undergoing transurethral resection of bladder tumor from December 2018 to May 2020 in the Department of General Surgery of Sri Guru Ramdas Institute of Medical Sciences and Research, Amritsar. Based on World Health Organization (WHO) classification incidence of various urothelial malignancy was calculated.Results: Out of 80 patients with growth urinary bladder, 4 patients (5% of total patient) were diagnosed as case of papilloma, 26 patients (32.5% of total patients) were diagnosed as low grade papillary urothelial carcinoma, 50 patients (62.5% of total patients) were of high grade papillary urothelial carcinoma. There were no case of PUNLMP in our study.Conclusions: It can be concluded that majority of the patient undergoing transurethral resection of bladder tumor are diagnosed with high grade papillary carcinoma. 

scholarly journals HISTOPATHOLOGICAL SPECTRUM OF UROTHELIAL LESIONS: AN OBSERVATIONAL STUDY

2020 ◽  
pp. 1-4
Author(s):  
Nishat Ahmad ◽  
Saurabh Banerjee ◽  
A K. Srivastava
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Tumour ◽  
Histopathological Analysis ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Carcinomas ◽  
Neoplastic Lesions ◽  
Papillary Urothelial Carcinoma ◽  
Muscle Invasion

BACKGROUND: Urinary bladder cancer is second most common cancer after prostate cancer in the genitourinary system. Urothelial Carcinoma is the commonest tumour type accounting for 90% of all primary tumours of the bladder Histopathological analysis of cystoscopic bladder biopsy and Transurethral resection of the bladder tumour (TURBT) material are the mainstay for cancer diagnosis. This study was aimed to determine the frequency of different types of neoplastic lesions of the urinary bladder and to determine the grade and stage of urothelial tumours. MATERIAL METHOD: The study was carried out in the Department of Pathology, Rajendra Institute of Medical Sciences (RIMS), Ranchi from January 2018 to June 2020 and included 30 cases of cystoscopic biopsies and TURBT specimens. RESULTS: Out of 30 cases of neoplastic lesions, majority were of high grade papillary urothelial carcinoma (n=14, 46.67%) followed by low grade papillary urothelial carcinoma (n=9, 30%), 3 cases (10%) were of PUNLMP, 2 cases (6.66%) of papilloma and 1 (3.33%) case each of moderately differentiated squamous cell carcinoma and extra nodal NHL. The most common age group was 41-50 years and 51-60 years with 9 (30%) cases each. Muscle invasion was seen only in high grade papillary urothelial carcinomas. CONCLUSION: High-grade urothelial carcinomas with lamina propria and muscle invasion are the most common neoplastic lesion of urinary bladder with significant morbidity and mortality. Muscle invasion and grading, as per TNM staging, are valuable prognostic factors.

scholarly journals A histopathologic study of urinary bladder tumors at tertiary care center in Mid-Western region of Nepal

2018 ◽  
Vol 9 (6) ◽  
pp. 45-50
Author(s):  
Binita Goyal ◽  
Sheshagiri Rao ◽  
Rajina Sahi ◽  
Subechhya Jaiswal
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Medical Sciences ◽  
Bladder Tumors ◽  
Common Cancer ◽  
Urothelial Tumors ◽  
Papillary Urothelial Carcinoma ◽  
Muscle Invasion

Background: Urinary bladder cancer is an important cause of morbidity and mortality due to urological conditions. It is tenth most common cancer overall in both sexes. It is seventh most common cancer overall and second most common cancer of genitourinary tract in males. Ninety five percent of bladder tumors are epithelial and the rest are mesenchymal, of which majority are primary urothelial tumors. Urothelial tumors are classified into infiltrating urothelial carcinoma with its variants and non-invasive urothelial neoplasias. Tumor stage is the strongest prognostic parameter.Aims and Objectives: The current study was designed with an aim to elucidate the histologic pattern of bladder tumors and observe whether any association between histologic grade and muscle invasion exists.Materials and Methods: This descriptive study was carried out on 84 cases of urinary bladder tumors received in Department of Pathology, College of Medical Sciences and Teaching Hospital during a time period of 5 years from January 2012 to December 2016.Results: The mean ± SD of age of presentation was 63±13 years with a male female ratio 3.2:1. Ninety-five percent cases were primary epithelial tumors and 93% cases were of urothelial origin. Low grade papillary urothelial carcinoma was the most common urothelial tumor (40.5%) followed by high grade papillary urothelial carcinoma (34.5%). Some rare types like primary adenocarcinoma and small cell carcinoma were also seen in this study (1.2% each). Muscle invasion was significantly higher in high grade (66%) as compared to low grade papillary urothelial carcinoma (3%). Muscle tissue was absent in 8 (9.5%) cases.Conclusion: There is relationship of histologic grade with aggressiveness of tumor. Most of the high grade tumors are muscle invasive at presentation. Submission of muscle tissue is important for optimal patient management.Asian Journal of Medical Sciences Vol.9(6) 2018 45-50

scholarly journals Urothelial Carcinoma of the Graft Kidney With Molecular Analyses: A Rare Case Report

2021 ◽  
Author(s):  
Joyce Chen ◽  
Kenneth Haines ◽  
William Lam ◽  
Asha Reddy ◽  
Meenakshi Mehrotra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Filling Defect ◽  
High Grade ◽  
Transplant Recipients ◽  
Increased Risk ◽  
Transplant Kidney ◽  
Obturator Lymph Node ◽  
Papillary Urothelial Carcinoma

Abstract BACKGROUNDMalignancy after transplantation is a leading cause of death in kidney transplant recipients. However, donor-derived malignancies are rarely reported. We herein report a high grade papillary urothelial carcinoma of the graft kidney, involving the graft ureter and native urinary bladder, invading one left obturator lymph node, and sparing the two native kidneys and ureters.CASE PRESENTATION62-year-old female with history of kidney transplantation more than 30 years ago, who presented with urinary tract infection, acute renal failure, and hydronephrosis of the transplant kidney. Anterograde nephrostogram showed a large filling defect in the lower pole of the transplant kidney and a filling defect in the proximal 3-4 cm of ureter. Biopsy taken from the renal pelvic mass showed a high grade urothelial carcinoma. She underwent hysterectomy, bilateral salpingo-oophorectomy, nephrectomy of native kidneys and transplant kidney, cystectomy and bilateral pelvic lymph node dissections. Histology showed a high grade papillary urothelial carcinoma of the graft kidney, involving the graft ureter, native urinary bladder and one left obturator lymph node and sparing the two native kidneys and ureters. Short tandem repeat (STR) analysis confirmed the tumor was of donor origin. The next-generation sequencing identified amplification of TERT and loss of CDKN2A/CDKN2B in the primary tumor.CONCLUSIONWhile it is known that transplant recipients have an increased risk of urothelial carcinoma compared to the general population, the lack of the well-documented risk factors, such as older age at transplantation, BK polyomavirus infection, and prolonged post-transplantation history and dissemination of the tumor in this case shed light on the de novo tumorigenesis of the graft kidney within the host microenvironment. Amplification of Telomerase reverse transcriptase (TERT) and loss of cyclin dependent kinase inhibitor 2A/2B (CDKN2A/CDKN2B) detected in the tumor by next gene sequencing suggests that they may play an important role in this case.

Papillary Urothelial Carcinoma of the Urinary Bladder Demonstrating Prominent Signet-Ring Cells in a Smear

1998 ◽  
Vol 42 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Toshihito Shinagawa ◽  
Mamoru Tadokoro ◽  
Mitsubumi Abe ◽  
Yutaka Koshitaka ◽  
Shoujiroh Kouno ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Signet Ring Cells ◽  
Signet Ring ◽  
Papillary Urothelial Carcinoma

Carcinomas in the bladder with papillary and pseudopapillary morphology - not always urothelial

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Daniel Abensur Athanazio ◽  
Maiara Ferreira de Souza ◽  
Maria Estela Pompeu do Amaral
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Final Diagnosis ◽  
Prostate Adenocarcinoma ◽  
High Grade ◽  
Case Presentation ◽  
Carcinoma Prostate ◽  
Papillary Urothelial Carcinoma ◽  
Primary Bladder ◽  
Bladder Adenocarcinoma

Abstract Background Urothelial carcinoma shows wide plasticity and broad morphologic spectrum. In many instances, the presence of papillary morphology is reassuring of the urothelial histogenesis of a high-grade invasive lesion but is not pathognomonic. Case presentation We reported herein four cases of carcinomas in the bladder with papillary morphology that had a final diagnosis different from urothelial carcinoma (3% of cases in a 42-month period). In high-grade tumors involving the urinary tract, the presence of papillary/pseudopapillary morphology is not sufficient to render a diagnosis of papillary urothelial carcinoma. Prostate adenocarcinoma, primary bladder adenocarcinoma or metastasis must be excluded in selected case scenarios.

scholarly journals Somatically derived Yolk Sac tumor of the urinary bladder: A case report and differential diagnosis

2020 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Enric Condom Mundó
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Final Diagnosis ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
High Grade ◽  
Yolk Sac Tumors ◽  
Urinary Bladder Tumor

Abstract Background: Yolk sac tumor is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These cases have been denominated recently as “somatically derived Yolk sac tumors”, and have been documented in several locations, although reports from the urinary tract are scarce. To our knowledge, this is the first report of a Yolk sac tumor derived from urothelial carcinoma. Case presentation: We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negativity for CK7 and EMA. Fluorescent in situ hybridization study showed a polysomic pattern of chromosome 12. All these findings led to the final diagnosis of a Yolk sac tumor derived from urothelial carcinoma. Conclusions: Somatically derived Yolk Sac tumors should be considered in the differential diagnosis of a high grade urothelial carcinoma, particularly when glandular and other unusual patterns are observed. Key words: Yolk sac tumor, somatically derived, urothelial carcinoma, urinary bladder, case report.

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