Protective effects of Artemisia campestris extract against gastric acid reflux-induced esophageal mucosa injuries

2018 ◽  
Vol 25 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Mohamed-Amine Jabri ◽  
Haifa Tounsi ◽  
Afifa Abdellaoui ◽  
Lamjed Marzouki ◽  
Hichem Sebai
Keyword(s):  
Gastric Acid ◽  
Acid Reflux ◽  
Esophageal Mucosa ◽  
Protective Effects ◽  
Artemisia Campestris

Gastric acid reflux triggers activation of epidermal growth factor receptor gene and proliferation in injured esophageal mucosa in rats

2000 ◽  
Vol 118 (4) ◽  
pp. A1235
Author(s):  
Yasuhiro Fujiwara ◽  
Kazuhide Higuchi ◽  
Takashi Takashima ◽  
Toshiyuki Uchida ◽  
Toshio Watanabe ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Gastric Acid ◽  
Receptor Gene ◽  
Growth Factor Receptor ◽  
Acid Reflux ◽  
Esophageal Mucosa ◽  
Epidermal Growth

Effect of Curculigo orchioides on Reflux Esophagitis by Suppressing Proinflammatory Cytokines

2012 ◽  
Vol 40 (06) ◽  
pp. 1241-1255 ◽  
Author(s):  
Sae-Kang Ku ◽  
Jae-Soo Kim ◽  
Young-Bae Seo ◽  
Yong-Ung Kim ◽  
Seung-Lark Hwang ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Group Treatment ◽  
Control Group ◽  
Esophageal Mucosa ◽  
Dependent Manner ◽  
Protective Effects ◽  
Model Group ◽  
Curculigo Orchioides ◽  
Intact Group ◽  
Tnf Α

This study was performed to investigate effects of Curculigo orchioides rhizome (curculiginis rhizome) on acute reflux esophigitis (RE) in rats that are induced by pylorus and forestomach ligation operation. Proinflammatory cytokine, as well as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were all assayed and the expression of TNF-α and COX2 analyzed by RT-PCR. The esophagic tissue damage of reflux esophagitis rat was increased compared to that of normal intact group. However, the esophagic damage percentage from the extract of curculiginis rhizoma (ECR) 600 mg/kg and ECR 300 mg/kg were significantly lower than that of the RE control group. Administration of α-tocopherol (30 mg/kg) and ECR (600 mg/kg, 300 mg/kg, and 150 mg/kg) had a significant effect on the gastric acid pH in rats with induced reflux esophagitis (p < 0.05). The treatment with ECR significantly reduced the production of cytokines TNF-α, IL-1β and IL-6 levels compared to the model group (p < 0.05). The expression of TNF-α and COX2 in the intact esophageal mucosa was low while those of the RE control group were significantly higher due to an inflammatory reaction in the esophagus. Compare to the model group, treatment with α-tocopherol or ECR significantly inhibited the expression levels of COX2 and TNF-α in a dose-dependent manner. These results suggest that anti-inflammatory and protective effects of ECR could attenuate the severity of reflux esophagitis and prevent esophageal mucosal damage.

scholarly journals Dichloromethane Extracts of Geranium Koreanum Kom. Alleviates Esophagus Damage in Acute Reflux Esophagitis-Induced Rats by Anti-Inflammatory Activities

2018 ◽  
Vol 19 (11) ◽  
pp. 3622 ◽  
Author(s):  
Hyeon Nam ◽  
Li Nan ◽  
Byung Choo
Keyword(s):  
Tight Junction ◽  
Reflux Esophagitis ◽  
Mucosal Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
No Production ◽  
Esophageal Mucosa ◽  
Protective Effects ◽  
Junction Protein ◽  
Inflammatory Proteins ◽  
Anti Inflammatory

Reflux esophagitis (RE) is a gastrointestinal disease caused by the reflux of gastric acid and stomach contents, and it leads to esophageal damage. Therefore, it is necessary to study the improvement of esophageal damage on a RE-induced model. The present study was accomplished to demonstrate the protective effects of a dichloromethane fraction of Geranium koreanum (DGK) plant on esophageal damage in an acute RE rat model. First, we examined the potential of anti-inflammatory effects of various fractions measured by cell cytotoxicity, morphological changes and nitric oxide (NO) production on lipopolysaccharide (LPS)-induced Raw 264.7 macrophage cells. Then, to evaluate the protective effects on RE, rats were partitioned into the following groups: normal control, RE-induced control and RE rats pre-treated with DGK 100 and 200 mg/kg body weight. The esophageal mucosal ulcer ratio was measured by the Image J program and histological changes were examined using a hematoxylin and eosin staining of the esophageal mucosa. The expression of pro-inflammatory proteins, cytokines and tight junction proteins involved in the esophageal mucosal damage were investigated using Western blotting and an enzyme-linked immunosorbent assay (ELISA) kit with esophagus tissue. DGK chemical profile and phenolic contents were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). The results showed that DGK exhibited anti-inflammatory effects against LPS-stimulated cells by significantly inhibiting NO production. Additionally, the results in vivo showed that improvement effects of DGK on esophageal mucosal damage. The expression of inflammatory proteins involved in nuclear factor κB (NF-κB) signaling pathways and tight junction protein (claudin-4 and -5) were significantly decreased in esophageal mucosa. We found the potential of DGK as source of replacement therapy products for inflammatory and RE disease.

scholarly journals Antioxidant and Protective Effects of Artemisia campestris Essential Oil Against Chlorpyrifos-Induced Kidney and Liver Injuries in Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Mongi Saoudi ◽  
Riadh Badraoui ◽  
Fatma Rahmouni ◽  
Kamel Jamoussi ◽  
Abdelfattah El Feki
Keyword(s):  
Essential Oil ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Protective Effects ◽  
Liver Injuries ◽  
Liver And Kidney ◽  
Artemisia Campestris ◽  
Morphologic Changes ◽  
Histopathologic Features

This study is aimed to elucidate the possible antioxidant and protective effects of Artemisia campestris essential oil (ACEO) against the deleterious effects of chlorpyrifos (CPF) in rats. The in vivo study revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) activities and the serum contents of creatinine, urea, uric acid, cholesterol, triglycerides, low density lipoproteins (LDL), and glucose in rats treated with CPF as compared to controls. Meanwhile, hepatic and renal activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and kidney decreased and the content of malondialdehyde (MDA) increased. Some histopathologic features were noticed in liver and kidney of the CPF group. Interestingly, ACEO alleviated the biochemical disruptions and reduced these hepato-renal morphologic changes.

Prior Sensitization of Esophageal Mucosa by Acid Reflux Predisposes to Reflux-induced Chest Pain

2000 ◽  
Vol 31 (2) ◽  
pp. 121-124 ◽  
Author(s):  
Ashok Beedassy ◽  
Philip O. Katz ◽  
Antonio Gruber ◽  
Paolo L. Peghini ◽  
Donald O. Castell
Keyword(s):  
Chest Pain ◽  
Acid Reflux ◽  
Esophageal Mucosa

scholarly journals Protective effects of Artemisia campestris upon fenthion-induced nephrotoxicity in adult rats and their progeny

2013 ◽  
Vol 32 (04) ◽  
pp. 577-588 ◽  
Author(s):  
Mediha Sefi ◽  
Afef Troudi ◽  
Fatma Ben Hamida ◽  
Nejla Soudani ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Protective Effects ◽  
Adult Rats ◽  
Artemisia Campestris

PREDICTING EFFICACY OF PROTON PUMP INHIBITORS IN REGULATING GASTRIC ACID SECRETION

2004 ◽  
Vol 12 (01) ◽  
pp. 1-34 ◽  
Author(s):  
DHRUV SUD ◽  
IAN M. P. JOSEPH ◽  
DENISE KIRSCHNER
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Acid Reflux ◽  
Published Data ◽  
Turnover Rates ◽  
Long Term Effects ◽  
Dosing Regimens

Developing drugs to treat gastric acid related illnesses such as ulcers and acid reflux disease is the leading focus of pharmaceutical companies. In fact, expenditure for treating these disorders is highest among all illnesses in the US. Over the last few decades, a class of drugs known as a proton pump inhibitors (PPIs) appeared on the market and are highly effective at abating gastric illnesses by raising stomach pH (reducing gastric acid levels). While much is known about the action of PPIs , there are still open questions regarding their efficacy, dosing and long-term effects. Here we extend a previous gastric acid secretion model developed by our group to incorporate a pharmacodynamic/pharmacokinetic model to study proton pump inhibitor (PPI) action. Model-relevant parameters for specific drugs such as omeprazole (OPZ) , lansoprazole (LPZ) and pantoprazole (PPZ) were used from published data, and we conducted simulations to study various aspects of PPI treatment. Clinical data suggests that duration of acid suppression is dependent on proton pump turnover rates and this is supported by our model. We found the order of efficacy of the different PPIs to be OPZ>PPZ>LPZ for clinically recommended dose values, and OPZ>PPZ=LPZ for equal doses. Our results indicate that a breakfast dose for once-daily dosing regimens and a breakfast-lunch dose for twice-daily dosing regimens is recommended. Simulation of other gastric disorders using our model provides atypical applications for the study of drug treatment on homeostatic systems and identification of potential side-effects.

scholarly journals Effect of Evodiae Fructus and Arecae Semen Mixture on Esophageal Mucosa in Chronic Acid Reflux Esophagitis

2021 ◽  
Vol 27 (2) ◽  
pp. 77-87
Author(s):  
Jin A Lee ◽  
Mi-Rae Shin ◽  
Hae-Jin Park ◽  
Seong-Soo Roh
Keyword(s):  
Reflux Esophagitis ◽  
Acid Reflux ◽  
Esophageal Mucosa
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