scholarly journals Effect of Evodiae Fructus and Arecae Semen Mixture on Esophageal Mucosa in Chronic Acid Reflux Esophagitis

2021 ◽  
Vol 27 (2) ◽  
pp. 77-87
Author(s):  
Jin A Lee ◽  
Mi-Rae Shin ◽  
Hae-Jin Park ◽  
Seong-Soo Roh
Keyword(s):  
Reflux Esophagitis ◽  
Acid Reflux ◽  
Esophageal Mucosa

scholarly journals Scutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPARγ/RXR Signaling in Reflux Esophagitis

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Jin A. Lee ◽  
Mi-Rae Shin ◽  
Hae-Jin Park ◽  
Seong-Soo Roh
Keyword(s):  
Body Weight ◽  
Reflux Esophagitis ◽  
Gastrointestinal Disorder ◽  
Acid Reflux ◽  
Mucosal Damage ◽  
Common Disease ◽  
Esophageal Mucosa ◽  
Water Control ◽  
Scutellariae Radix ◽  
The Impact

Objective. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder in which stomach contents reflux into the esophagus, causing complications such as mucosal damage. GERD is a very common disease and is on the rise worldwide. The aim of this study was to assess the impact of a Scutellariae Radix and Citri Reticulatae Pericarpium mixture (SC) on esophageal mucosal injury in rats with chronic acid reflux esophagitis (CARE). Methods. After inducing reflux esophagitis through surgery, the group was separated and the drug was administered for 2 weeks: normal rats (Normal, n = 8), CARE-induced rats were treated with distilled water (Control, n = 8), CARE-induced rats were treated with vitamin E 30 mg/kg body weight (VitE, n = 8), CARE-induced rats were treated with SC 100 mg/kg body weight (SC100, n = 8), and CARE-induced rats were treated with SC 200 mg/kg body weight (SC200, n = 8). Results. SC treatment significantly reduced the degree of esophageal mucosal damage, significantly reduced levels of MDA and MPO, and inhibited the activation of the NF-κB inflammatory pathway by activating the PPARγ/RXR pathway. In addition, SC treatment significantly regulated the expression of arachidonic acid-related proteins (COX-1, COX-2, and PGE2) and modulated the MMP/TIMP proteins in reflux esophagitis. Conclusion. Consequently, SC improved the damage to the esophageal mucosa. Also, the anti-inflammatory effects of the SC suggested the inhibition of NF-κB pathway through the activation of the PPARγ/RXR pathway, thereby reducing the expression of inflammation-related cytokines.

Effect of Curculigo orchioides on Reflux Esophagitis by Suppressing Proinflammatory Cytokines

2012 ◽  
Vol 40 (06) ◽  
pp. 1241-1255 ◽  
Author(s):  
Sae-Kang Ku ◽  
Jae-Soo Kim ◽  
Young-Bae Seo ◽  
Yong-Ung Kim ◽  
Seung-Lark Hwang ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Group Treatment ◽  
Control Group ◽  
Esophageal Mucosa ◽  
Dependent Manner ◽  
Protective Effects ◽  
Model Group ◽  
Curculigo Orchioides ◽  
Intact Group ◽  
Tnf Α

This study was performed to investigate effects of Curculigo orchioides rhizome (curculiginis rhizome) on acute reflux esophigitis (RE) in rats that are induced by pylorus and forestomach ligation operation. Proinflammatory cytokine, as well as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were all assayed and the expression of TNF-α and COX2 analyzed by RT-PCR. The esophagic tissue damage of reflux esophagitis rat was increased compared to that of normal intact group. However, the esophagic damage percentage from the extract of curculiginis rhizoma (ECR) 600 mg/kg and ECR 300 mg/kg were significantly lower than that of the RE control group. Administration of α-tocopherol (30 mg/kg) and ECR (600 mg/kg, 300 mg/kg, and 150 mg/kg) had a significant effect on the gastric acid pH in rats with induced reflux esophagitis (p < 0.05). The treatment with ECR significantly reduced the production of cytokines TNF-α, IL-1β and IL-6 levels compared to the model group (p < 0.05). The expression of TNF-α and COX2 in the intact esophageal mucosa was low while those of the RE control group were significantly higher due to an inflammatory reaction in the esophagus. Compare to the model group, treatment with α-tocopherol or ECR significantly inhibited the expression levels of COX2 and TNF-α in a dose-dependent manner. These results suggest that anti-inflammatory and protective effects of ECR could attenuate the severity of reflux esophagitis and prevent esophageal mucosal damage.

GERD an ayurvedic management : A review article

2019 ◽  
Vol 7 (05) ◽  
Author(s):  
Ramesh Pawar ◽  
Gadve N. B.
Keyword(s):  
Present Article ◽  
Reflux Esophagitis ◽  
Acid Reflux ◽  
Review Article ◽  
Satisfactory Treatment ◽  
Spicy Food

GERD correlated with the disease Amlapitta, described in ayurveda. GERD occurs when digestive juices moves upward from the stomach in to the esophagus  causing Acid reflux. Lifestyle eating too late at night , spicy food , alcohol , smoking tobacco,  coffee , tea ,causes GERD. heartburn , regurgitation and difficulty swallowing are common symptoms seen in GERD. till date no satisfactory treatment is available for GERD with reflux esophagitis. In the present article an attempt has been made to emphasis on herbal option for GERD.

scholarly journals Dichloromethane Extracts of Geranium Koreanum Kom. Alleviates Esophagus Damage in Acute Reflux Esophagitis-Induced Rats by Anti-Inflammatory Activities

2018 ◽  
Vol 19 (11) ◽  
pp. 3622 ◽  
Author(s):  
Hyeon Nam ◽  
Li Nan ◽  
Byung Choo
Keyword(s):  
Tight Junction ◽  
Reflux Esophagitis ◽  
Mucosal Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
No Production ◽  
Esophageal Mucosa ◽  
Protective Effects ◽  
Junction Protein ◽  
Inflammatory Proteins ◽  
Anti Inflammatory

Reflux esophagitis (RE) is a gastrointestinal disease caused by the reflux of gastric acid and stomach contents, and it leads to esophageal damage. Therefore, it is necessary to study the improvement of esophageal damage on a RE-induced model. The present study was accomplished to demonstrate the protective effects of a dichloromethane fraction of Geranium koreanum (DGK) plant on esophageal damage in an acute RE rat model. First, we examined the potential of anti-inflammatory effects of various fractions measured by cell cytotoxicity, morphological changes and nitric oxide (NO) production on lipopolysaccharide (LPS)-induced Raw 264.7 macrophage cells. Then, to evaluate the protective effects on RE, rats were partitioned into the following groups: normal control, RE-induced control and RE rats pre-treated with DGK 100 and 200 mg/kg body weight. The esophageal mucosal ulcer ratio was measured by the Image J program and histological changes were examined using a hematoxylin and eosin staining of the esophageal mucosa. The expression of pro-inflammatory proteins, cytokines and tight junction proteins involved in the esophageal mucosal damage were investigated using Western blotting and an enzyme-linked immunosorbent assay (ELISA) kit with esophagus tissue. DGK chemical profile and phenolic contents were analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). The results showed that DGK exhibited anti-inflammatory effects against LPS-stimulated cells by significantly inhibiting NO production. Additionally, the results in vivo showed that improvement effects of DGK on esophageal mucosal damage. The expression of inflammatory proteins involved in nuclear factor κB (NF-κB) signaling pathways and tight junction protein (claudin-4 and -5) were significantly decreased in esophageal mucosa. We found the potential of DGK as source of replacement therapy products for inflammatory and RE disease.

Prior Sensitization of Esophageal Mucosa by Acid Reflux Predisposes to Reflux-induced Chest Pain

2000 ◽  
Vol 31 (2) ◽  
pp. 121-124 ◽  
Author(s):  
Ashok Beedassy ◽  
Philip O. Katz ◽  
Antonio Gruber ◽  
Paolo L. Peghini ◽  
Donald O. Castell
Keyword(s):  
Chest Pain ◽  
Acid Reflux ◽  
Esophageal Mucosa

scholarly journals Increased Immunoreactivity of Cathepsins in the Rat Esophagus under Chronic Acid Reflux Esophagitis

2014 ◽  
Vol 62 (9) ◽  
pp. 645-660 ◽  
Author(s):  
Masayuki Suyama ◽  
Masato Koike ◽  
Daisuke Asaoka ◽  
Hiroki Mori ◽  
Masako Oguro ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Acid Reflux

PS01.142: THE IMPACT OF CERVICAL LYMPH NODE DISSECTION ON ACID AND DUODENOGASTROESOPHAGEAL REFLUX AFTER INTRATHORACIC ESOPHAGOGASTROSTOMY FOLLOWING TRANSTHORACIC ESOPHAGECTOMY

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 90-90
Author(s):  
Masahide Fukaya ◽  
Kazushi Miyata ◽  
Keita Itatsu ◽  
Soichiro Asai ◽  
Kimitoshi Yamazaki ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Reflux Esophagitis ◽  
Cervical Lymph Node ◽  
Acid Reflux ◽  
Transthoracic Esophagectomy ◽  
Node Dissection ◽  
Cervical Lymph Node Dissection ◽  
Duodenogastroesophageal Reflux ◽  
The Impact

Abstract Background The aim of this study was to evaluate the impact of cervical lymph node dissection on acid and duodenogastroesophageal reflux (DGER) in patients undergoing transthoracic esophagectomy with gastric tube reconstruction and intrathoracic esophagogastrostomy. Methods Thirty one patients receiving transthoracic esophagectomy gastric tube reconstruction by intrathoracic esophagogastrostomy were subjected and divided into two groups: two field lymph node dissection group (the 2F group) and three field lymph node dissection group (the 3F group). All patients underwent 24h pH and bilirubin monitoring and gastrointestinal endoscopy one year after surgery. The results of 24h pH and bilirubin monitoring, endoscopic findings, and reflux symptoms, were compared between two groups. Results No acid reflux was observed in the 2F group, whereas it was observed in 6 (40%) of the 3F group (P = 0.023). DGER was observed in 2 patients (13%) of the 2F groups, whereas it was observed in 8 (53%) of the 3F group (P = 0.007). The percentage time of acid reflux in the 3F group was significant higher than that in the 2F group (median 0.8 vs 0%, P = 0.008). The percentage time of bile reflux in the 3F group was also significantly higher than that in the 2F group (median 2.600 vs 0%, P = 0.027). Four patients (25%) had reflux esophagitis in the 2F group, and nine patients (60%) had reflux esophagitis in the 3F group (P = 0.048). Conclusion Cervical lymph node dissection increases acid reflux and duodenogastroesophageal reflux, and can lead to the increase of the incidence of reflux esophagitis in patient with intrathoracic esophagogastrostomy. Disclosure All authors have declared no conflicts of interest.

Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis

2005 ◽  
Vol 40 (8) ◽  
pp. 781-790 ◽  
Author(s):  
Daisuke Asaoka ◽  
Hiroto Miwa ◽  
Shu Hirai ◽  
Akimitsu Ohkawa ◽  
Akihiko Kurosawa ◽  
...  
Keyword(s):  
Tight Junction ◽  
Reflux Esophagitis ◽  
Rat Model ◽  
Acid Reflux ◽  
Tight Junction Proteins ◽  
Junction Proteins
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