Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review

2021 ◽  
pp. 105841
Author(s):  
Omid Yazarlu ◽  
Mehrdad Iranshahi ◽  
Hamid Reza Khayat Kashani ◽  
Sara Reshadat ◽  
Solomon Habtemariam ◽  
...  

Author(s):  
Christian Agyare ◽  
Emelia Oppong Bekoe ◽  
Yaw Duah Boakye ◽  
Susanna Oteng Dapaah ◽  
Theresa Appiah ◽  
...  


Author(s):  
Kamal Solati ◽  
Mehrdad Karimi ◽  
Mahmoud Rafieian-Kopaei ◽  
Naser Abbasi ◽  
Saber Abbaszadeh ◽  
...  

: Wound healing is a process which starts with inflammatory response after damage occurrence. This process happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound. However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.





2021 ◽  
Vol 22 ◽  
Author(s):  
Harsha Negi ◽  
Meenakshi Gupta ◽  
Ramanpreet Walia ◽  
Moayad Khataibeh ◽  
Maryam Sarwat

: Obesity is a major lifestyle disorder and it is correlated with several ailments. The prevalence of obesity has elevated over the years and it has become a global health problem. The drugs presently used for managing obesity have several side-effects associated with them such as diarrhoea, leakage of oily stools, etc. On the contrary, herbal plants and natural products are considered safe for use because they have lesser side effects. New compounds isolated from medicinal plants are screened and identified to determine their effectiveness and potential in preventing abnormal weight gain. In this review, the medicinal plants and natural materials were surveyed across the literature to cover those that have potential for managing and controlling weight gain, and their mechanism of action, active component, and experimental methodologies are also included. These herbal products can be developed as formulations for therapeutic use in obesity. The herbal plants mentioned in the review are classified based on their mechanism of action: inhibition of pancreatic lipase and appetite suppression activities. The ability to inhibit pancreatic lipase enzyme has been used to determine the effectiveness of herbal products for the prevention of abnormal weight gain because of its action on dietary fat and suppression of appetite. This review is an attempt to summarize the herbal plants and natural products that can be used to develop formulations effective in controlling weight gain and obesity.



2021 ◽  
Vol 20 ◽  
Author(s):  
Choy Ker Woon ◽  
Wong Kah Hui ◽  
Razif Abas ◽  
Muhammad Huzaimi Haron ◽  
Srijit Das ◽  
...  

: Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and its severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano- sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material’s bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicine-based approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future.



2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Shixin Deng ◽  
Shao-Nong Chen ◽  
Jian Yang


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