Combined in utero hypoxia-ischemia and lipopolysaccharide administration in rats induces chorioamnionitis and a fetal inflammatory response syndrome

Placenta ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 1378-1384 ◽  
Author(s):  
Jessie R. Maxwell ◽  
Jesse L. Denson ◽  
Nancy E. Joste ◽  
Shenandoah Robinson ◽  
Lauren L. Jantzie
Keyword(s):  
Inflammatory Response ◽  
In Utero ◽  
Hypoxia Ischemia ◽  
Fetal Inflammatory Response

scholarly journals Fetal Inflammatory Response Syndrome Associated With SARS-CoV-2 Exposure In Utero

2022 ◽  
Vol 19 (4) ◽  
Author(s):  
Mahesh D Shinde ◽  
Anilkumar M Khamkar ◽  
Pralhad D Pote ◽  
Pradeep B Suryawanshi
Keyword(s):  
Inflammatory Response ◽  
In Utero ◽  
Fetal Inflammatory Response

Fetal Inflammatory Response Syndrom: Leidet die zerebrale Sauerstoffversorgung?

2020 ◽  
Vol 224 (05) ◽  
pp. 243-243
Keyword(s):  
Inflammatory Response ◽  
Interleukin 6 ◽  
Fetal Inflammatory Response

Ein sogenanntes FIRS (fetal inflammatory response syndrome) liegt per Definition vor, wenn in Folge einer systemischen Aktivierung des fetalen Immunsystems im Nabelschnurblut erhöhte Interleukin-6(IL-6)-Spiegel gemessen werden. Die betroffenen Kinder haben ein erhöhtes Komplikations- und Sterberisiko. Beeinträchtigt das FIRS die zerebrale Sauerstoffversorgung von Frühgeborenen innerhalb der ersten Lebensminuten?

scholarly journals Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lívia Helena M. Pereira ◽  
Juliana R. Machado ◽  
Janaínna G. P. Olegário ◽  
Laura P. Rocha ◽  
Marcos V. Silva ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Stress ◽  
University Hospital ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Ascending Infection ◽  
Term Births ◽  
Liver Fragments ◽  
Fetal Inflammatory Response

Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death. Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus. IL-6, TNF-α, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody. Cases with congenital malformation, ascending infection, and perinatal anoxia showed increased IL-6, CRP, and TNF-α, respectively. Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP. Cases classified as acute stress presented higher expression of IL-6 and TNF-αand cases with chronic stress presented higher expression of CRP. GA correlated negatively with IL-6 and positively with CRP and TNF-α. Body weight correlated negatively with IL-6 and positively with CRP and TNF-α. Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current study allow the inference of FIRS diagnosis in the autopsied infants, based on anin situliver analysis of these markers.

scholarly journals Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
T. Nakamura ◽  
D. Hatanaka ◽  
T. Yoshioka ◽  
S. Yamada ◽  
H. Goto
Keyword(s):  
Inflammatory Response ◽  
Proinflammatory Cytokines ◽  
Proinflammatory Cytokine ◽  
Clinical Laboratory ◽  
Diagnosis And Treatment ◽  
Antibiotic Administration ◽  
Acute Phase Reactants ◽  
Group I ◽  
Cytokine Levels ◽  
Fetal Inflammatory Response

Background. Delayed diagnosis and treatment of newborn infection adversely impact outcomes. Clinical laboratory parameters have aimed to obtain the most correct and prompt diagnosis and treatment of this disease. This study simultaneously observed changes over time in APR as well as proinflammatory cytokines and anti-proinflammatory cytokines and aims to clarify usefulness of APR scores.Methods. We evaluated the usefulness of acute phase reactants (APR) in 46 newborns whose serum up to age 7 days had been stored, with comparison of three types (Group I: infection 15, Group F: fetal inflammatory response syndrome 17, and Group C: control 14) of APR-based scores, those of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), and haptoglobin (Hp), with proinflammatory cytokine levels. APR scores for CRP, AGP, and Hp and the levels of the proinflammatory cytokines IL-1β, IL-6, IL-8, IL-10, and TNFαwere determined.Results. The cytokine levels started to increase from age 0 days and then decreased rapidly. The three APR scores, CRP, AG, and Hp, were elevated at age 0 days and then gradually decreased in infection (Group I) and fetal inflammatory response syndrome (Group F). The duration of antibiotic administration according to APR scores was significantly shorter in Group F than in Group I.Conclusion. This study demonstrated APR scores to be more useful for deciding whether antibiotics should be discontinued than proinflammatory cytokine levels.

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