scholarly journals Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest

2019 ◽  
Vol 147 ◽  
pp. 6-14 ◽  
Author(s):  
Reggie Hui-Chao Lee ◽  
Alexandre Couto e Silva ◽  
HarLee E. Possoit ◽  
Francesca M. Lerner ◽  
Po-Yi Chen ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Acid Methyl Ester ◽  
Neuroprotective Agent ◽  
Acid Methyl ◽  
Palmitic Acid Methyl Ester

scholarly journals Palmitic Acid Methyl Ester Inhibits Cardiac Arrest-Induced Neuroinflammation and Mitochondrial Dysfunction

2020 ◽  
pp. 102227
Author(s):  
Celeste Yin-Chieh Wu ◽  
Alexandre Couto e Silva ◽  
Cristiane T. Citadin ◽  
Garrett A. Clemons ◽  
Christina H Acosta ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Mitochondrial Dysfunction ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Palmitic Acid Methyl Ester

Separation and characterization of 61- and 57-kDa lipases from Geotrichum candidum ATCC 66592

1992 ◽  
Vol 38 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Tomas Jacobsen ◽  
Otto M. Poulsen
Keyword(s):  
Oleic Acid ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Initial Velocity ◽  
Acid Methyl Ester ◽  
Geotrichum Candidum ◽  
Acid Methyl ◽  
Oleic Acid Methyl Ester ◽  
Palmitic Acid Methyl Ester ◽  
Hydrolysis Of

Two lipolytic proteins (61 and 57 kDa) present in a Sephadex G-100 fraction of extracellular lipase from Geotrichum candidum ATCC 66592 were separated using high-performance liquid chromatography. Crossed electrofocusing immunoelectrophoresis was used to demonstrate that the 61-kDa lipase fraction contained two forms of lipase with pI 4.5 and 4.7. However, when deglycosylated with endoglycosidase H, the two forms gained an identical pI, 4.6. The 57-kDa lipase fraction contained one form of lipase with pI close to 4.5. Although the 61- and 57-kDa lipases were immunologically identical, the substrate specificity differed. Thus, the 61-kDa lipase hydrolysed palmitic acid methyl ester at an initial velocity of hydrolysis that was 60% of the initial velocity of hydrolysis of oleic acid methyl ester, whereas the 57-kDa lipase hydrolysed palmitic acid methyl ester at an initial velocity of hydrolysis that was only7% of the initial velocity of hydrolysis of oleic acid methyl ester. Key words: Geotrichum candidum, lipases, multiple forms, deglycosylation, substrate specificity.

UJI FITOKIMIA DAN GC-MS DAUN UROKEP (SENNA ALATA) SEBAGAI BAHAN OBAT PELANGSING TRADISIONAL ASAL NYAPA INDAH, BERAU

2020 ◽  
Vol 10 (1) ◽  
pp. 48
Author(s):  
Andrian Fernandes
Keyword(s):  
Methyl Ester ◽  
Palmitic Acid ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Benzenedicarboxylic Acid ◽  
Palmitic Acid Methyl Ester ◽  
Senna Alata

Daun Senna alata telah dikenal sebagai obat penyakit kulit akibat parasit. Namun, di Dusun Nyapa Indah, Kabupaten Berau, Kalimantan Timur, daun Senna alata yang dikenal sebagai Urokep, secara tradisional rebusan daun keringnya digunakan sebagai obat pelangsing. Untuk meningkatkan kegunaan herbal menjadi produk obat herbal yang aman dikonsumsi khalayak umum, harus dilakukan proses pengilmiahan melalui uji fitokimia dan GC-MS, demikian pula dengan daun Urokep. Hasil uji fitokimia ekstrak etanol daun Urokep menunjukkan bahwa daun Urokep mengandung tannin, alkaloid, flavonoid, steroid dan triterpenoid. Kandungan tannin dan flavanoid dalam buah atau sayur yang dikonsumsi sehari sekali sudah cukup untuk digunakan sebagai program diet. Hasil uji GC-MS, diduga ekstrak etanol Urokep mengandung dua puluh komponen bahan kimia aktif, diantaranya 18,11% 1,2-Benzenedicarboxylic acid, mono(2-ethylhexyl) ester, 15,7% Palmitic acid, methyl ester dan 7,75% Beta-sitosterol yang dapat digunakan sebagai bahan untuk obat-obatan aktif dalam industri farmasi.Kata kunci : Urokep, Senna alata, pelangsing, fitokimia, GC-MS

Phase Diagram of α-Sulfonated Palmitic Acid Methyl Ester Sodium Salt−Water System

Langmuir ◽  
1997 ◽  
Vol 13 (13) ◽  
pp. 3345-3348 ◽  
Author(s):  
M. Fujiwara ◽  
T. Okano ◽  
H. Amano ◽  
H. Asano ◽  
K. Ohbu
Keyword(s):  
Phase Diagram ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Sodium Salt ◽  
Salt Water ◽  
Water System ◽  
Acid Methyl Ester ◽  
Acid Methyl ◽  
Palmitic Acid Methyl Ester

scholarly journals Isoprenoids and Fatty Acids Derivatives from the Chloroform Fraction of the Antimycobacterial Methanol Extract Ximeniaamericana Lam. (Olacaceae) Stem Bark

2019 ◽  
Vol 6 (2) ◽  
pp. 101-106
Author(s):  
Ozadheoghene Eriarie Afieroho ◽  
L. Lawson ◽  
Nnamdi Emenyonu
Keyword(s):  
Fatty Acids ◽  
Mycobacterium Tuberculosis ◽  
Methyl Ester ◽  
Palmitic Acid ◽  
Methanol Extract ◽  
Octadecenoic Acid ◽  
Acid Methyl Ester ◽  
Stem Bark ◽  
Clinical Strains ◽  
Acid Methyl

This study investigated the triterpenoids and fatty acid derivatives, and the in vitro growth inhibitory effect against clinical strains of Mycobacteria tuberculosis of the stem bark of Ximenia Americanaa plant widely used in ethno-medicine for the treatment of bacterial and skin infections, poison, post-partum hemorrhage, anaemia, and dysentery. The macerated methanol extract (XAM) of the stem bark was evaluated for anti-tuberculosis activity using the Lowensten Jensen method against de-contaminated clinical strains of Mycobacterium tuberculosis. The XAM was fractionated by open column chromatography on a normal phase silica gel column with a 25 % stepwise gradient of chloroform-methanol as mobile phase. The constituents of the non-polar column fractions eluted with 100% chloroform were characterized using Gas Chromatography-Mass spectroscopic (GC-MS) techniques and by comparison with reference NIST library compound. The XAM (5 mg/mL) inhibited the growth of the Mycobacterium tuberculosis. GC-MS analysis of the non-polar column fractions afforded Two lupane-type triterpenoids: Lup-20-(29)-en-3-one (15) and lupeol (16), three phytosteroids: campesterol (11), stigmasterol (12) and gamma-sitosterol (14), one fridelane-type triterpenoid: Friedelan-3-one (8), one oleanane-type triterpenoid: 12-oleanen-3-one (13), and the fatty acids: Palmitic acid methyl ester (1), Palmitic acid (2), 11-octadecenoic acid methyl ester (3), Octadecanoic acid methyl ester (4), Cis-13-Octadecenoic acid (5), 10,13-octadecadiynoic acid methyl ester (6), Docosanoic acid (7), Tetracosanoic acid (9), and Hexacosanoic acid methyl ester (10). The presence of these bioactive triterpenoids and fatty acids could offer an explanation for the ethno-medicinal uses of this plant. Further work is on-going to isolate in pure form, and characterized the bioactive constituents in the XAM with the view of discovery lead compounds for the treatment of tuberculosis and associated opportunistic bacterial infections.  

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