Carrier-free nanomedicines for cancer treatment

2022 ◽  
pp. 100919
Author(s):  
Li-Han Liu ◽  
Xian-Zheng Zhang
Keyword(s):  
Cancer Treatment ◽  
Carrier Free

Enhanced Photothermal Heating and Combination Therapy of NIR Dye via Conversion to Self-Assembled Ionic Nanomaterials

2022 ◽  
Author(s):  
Samantha P Macchi ◽  
Amanda Jalihal ◽  
Nasrin Hooshmand ◽  
Mohd Zubair ◽  
Nabeel Alwan ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Tumor Site ◽  
New Class ◽  
Photothermal Heating ◽  
Carrier Free ◽  
Self Assembled ◽  
Nir Dye

Combination nanodrugs are promising therapeutic agents for cancer treatment. However, they often require the use of complex nanovehicles for transportation into the tumor site. Herein, a new class of carrier-free...

scholarly journals Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

2018 ◽  
Vol 19 (10) ◽  
pp. 2963 ◽  
Author(s):  
Ying Wang ◽  
Pengfei Yang ◽  
Xinrui Zhao ◽  
Di Gao ◽  
Na Sun ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Clinical Applications ◽  
Self Monitoring ◽  
Promising Strategy ◽  
Carrier Free ◽  
Future Challenges

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.

scholarly journals Carrier-free nanodrugs for safe and effective cancer treatment

2020 ◽  
Author(s):  
Sena Karaosmanoglu ◽  
Mengjiao Zhou ◽  
Bingyang Shi ◽  
Xiujuan Zhang ◽  
Gareth R. Williams ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Carrier Free

Nano-rods of doxorubicin with poly(l-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment

2016 ◽  
Vol 4 (45) ◽  
pp. 7283-7292 ◽  
Author(s):  
Saina Yang ◽  
Feiyan Zhu ◽  
Qian Wang ◽  
Fuxin Liang ◽  
Xiaozhong Qu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Cancer Treatment ◽  
Survival Time ◽  
Release Profile ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Carrier Free ◽  
Nano Rods

Nano-rods of doxorubicin (DOX) were prepared by co-assembly with poly(l-glutamic acid) (PGA) and demonstrated a desired release profile for intratumoral administration that significantly prolonged the survival time of tumor-bearing mice.

A carrier-free nanoparticle with dual NIR/acid responsiveness by co-assembly of enediyne and IR820 for combined PTT/chemo therapy

2021 ◽  
Author(s):  
Haotian Lu ◽  
Wenbo Wang ◽  
Xiaoxuan Li ◽  
Mengsi Zhang ◽  
Xiaoyu Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Chemotherapeutic Drug ◽  
Carrier Free ◽  
Traditional Drug

Combined photothermal therapy/chemotherapy by co-delivery of photosensitizer (PS) and chemotherapeutic drug has demonstrated great potential for cancer treatment. The intrinsic drawbacks of traditional drug delivery systems (DDS), such as tedious...

1077: A Novel Apoptosis-Inducing Gene and its Application in Prostate Cancer Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 284-284
Author(s):  
Yi Lu ◽  
Jun Zhang ◽  
Ben Beheshti ◽  
Ximing J. Yang ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment
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