Enhanced Photothermal Heating and Combination Therapy of NIR Dye via Conversion to Self-Assembled Ionic Nanomaterials

Combination nanodrugs are promising therapeutic agents for cancer treatment. However, they often require the use of complex nanovehicles for transportation into the tumor site. Herein, a new class of carrier-free...

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Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Nanoscale ◽

10.1039/c7nr03129g ◽

2017 ◽

Vol 9 (38) ◽

pp. 14347-14356 ◽

Cited By ~ 49

Author(s):

Yan Wen ◽

Wei Zhang ◽

Ningqiang Gong ◽

Yi-Feng Wang ◽

Hong-Bo Guo ◽

...

Keyword(s):

Combination Therapy ◽

Self Assembly ◽

Chlorin E6 ◽

Antitumor Therapy ◽

Carrier Free ◽

Pure Drug ◽

Self Assembled

Carrier-free nanodrug HCPT/Ce6 NRs were prepared through a simple self-assembly approach for chemo-photodynamic combination therapy of tumors in vivo.

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Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

International Journal of Molecular Sciences ◽

10.3390/ijms19102963 ◽

2018 ◽

Vol 19 (10) ◽

pp. 2963 ◽

Cited By ~ 2

Author(s):

Ying Wang ◽

Pengfei Yang ◽

Xinrui Zhao ◽

Di Gao ◽

Na Sun ◽

...

Keyword(s):

Clinical Trials ◽

Cancer Therapy ◽

Drug Release ◽

Combination Therapy ◽

Cancer Treatment ◽

Clinical Applications ◽

Self Monitoring ◽

Promising Strategy ◽

Carrier Free ◽

Future Challenges

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.

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Identification of 2-Fluoropalmitic Acid as a Potential Therapeutic Agent Against Glioblastoma

Current Pharmaceutical Design ◽

10.2174/1381612826666200429092742 ◽

2020 ◽

Vol 26 (36) ◽

pp. 4675-4684 ◽

Cited By ~ 1

Author(s):

Shabierjiang Jiapaer ◽

Takuya Furuta ◽

Yu Dong ◽

Tomohiro Kitabayashi ◽

Hemragul Sabit ◽

...

Keyword(s):

Combination Therapy ◽

Drug Screening ◽

Therapeutic Agent ◽

Gelatin Zymography ◽

Therapeutic Agents ◽

Drug Candidate ◽

Potential Therapeutic Agent ◽

Sphere Formation ◽

Improve Patient

Background: Glioblastomas (GBMs) are aggressive malignant brain tumors. Although chemotherapy with temozolomide (TMZ) can extend patient survival, most patients eventually demonstrate resistance. Therefore, novel therapeutic agents that overcome TMZ chemoresistance are required to improve patient outcomes. Purpose: Drug screening is an efficient method to find new therapeutic agents from existing drugs. In this study, we explored a novel anti-glioma agent by drug screening and analyzed its function with respect to GBM treatment for future clinical applications. Methods: Drug libraries containing 1,301 diverse chemical compounds were screened against two glioma stem cell (GSC) lines for drug candidate selection. The effect of selected agents on GSCs and glioma was estimated through viability, proliferation, sphere formation, and invasion assays. Combination therapy was performed to assess its ability to enhance TMZ cytotoxicity against GBM. To clarify the mechanism of action, we performed methylation-specific polymerase chain reaction, gelatin zymography, and western blot analysis. Results: The acyl-CoA synthetase inhibitor 2-fluoropalmitic acid (2-FPA) was selected as a candidate anti-glioma agent. 2-FPA suppressed the viability and stem-like phenotype of GSCs. It also inhibited proliferation and invasion of glioma cell lines. Combination therapy of 2-FPA with TMZ synergistically enhanced the efficacy of TMZ. 2-FPA suppressed the expression of phosphor-ERK, CD133, and SOX-2; reduced MMP-2 activity; and increased methylation of the MGMT promoter. Conclusion: 2-FPA was identified as a potential therapeutic agent against GBM. To extend these findings, physiological studies are required to examine the efficacy of 2-FPA against GBM in vivo.

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In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽

10.1039/d1nr01155c ◽

2021 ◽

Author(s):

Jianqin Yan ◽

Zhuangzhuang Zhang ◽

xiaohui Zhan ◽

Keqi Chen ◽

Yuji Pu ◽

...

Keyword(s):

Combination Therapy ◽

Cancer Treatment ◽

Deep Penetration ◽

Tumor Penetration ◽

Dna Nanostructure ◽

Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

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Development of carrier-free self-assembled nanoparticles based on fenhexamid and polyhexamethylene biguanide for sustainable plant disease management

Green Chemistry ◽

10.1039/d1gc00006c ◽

2021 ◽

Vol 23 (6) ◽

pp. 2531-2540

Author(s):

Gang Tang ◽

Yuyang Tian ◽

Junfan Niu ◽

Jingyue Tang ◽

Jiale Yang ◽

...

Keyword(s):

Disease Management ◽

Plant Disease ◽

Polyhexamethylene Biguanide ◽

Adverse Impacts ◽

Pesticide Formulations ◽

Carrier Free ◽

Self Assembled ◽

Plant Disease Management

The utilization of nanotechnology for the design of pesticide formulations has enormous potential to enhance the efficiency of pesticides and reduce their adverse impacts on the environment

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