Relationship between powder properties and uniformity of ribbon property using feeding guider designs with thermography (PAT) in roller compaction

2022 ◽  
pp. 117134
Author(s):  
Mingzhe Yu ◽  
Chalak Omar ◽  
Marcus Weidemann ◽  
Alexander Schmidt ◽  
James D. Litster ◽  
...  
Keyword(s):  
Roller Compaction ◽  
Powder Properties

scholarly journals Impact of Powder Properties on the Rheological Behavior of Excipients

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1198
Author(s):  
Pauline H. M. Janssen ◽  
Sébastien Depaifve ◽  
Aurélien Neveu ◽  
Filip Francqui ◽  
Bastiaan H. J. Dickhoff
Keyword(s):  
Flow Field ◽  
Rheological Behavior ◽  
Quality By Design ◽  
Filling Process ◽  
Dynamic Flow ◽  
Die Filling ◽  
Flow Characterization ◽  
Wide Range ◽  
Powder Properties ◽  
The Impact

With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. Particle size distribution was identified as a main contributing factor to the rheological behavior of powders. The presence of fines between larger particles turned out to reduce the rheological index, which the authors explain by improved particle separation at more dynamic flow fields. This study also revealed that obtained insights on rheological behavior can be used to optimize agitator settings in a tableting machine.

Combustion synthesis of nanocrystalline Zr0.80Ce0.20O2: Detailed investigations of the powder properties

2008 ◽  
Vol 457 (1-2) ◽  
pp. 498-505 ◽  
Author(s):  
V. Grover ◽  
S.V. Chavan ◽  
P.U. Sastry ◽  
A.K. Tyagi
Keyword(s):  
Combustion Synthesis ◽  
Powder Properties

Modeling and Control of Roller Compaction for Pharmaceutical Manufacturing

2010 ◽  
Vol 5 (1-2) ◽  
pp. 24-36 ◽  
Author(s):  
Shuo-Huan Hsu ◽  
Gintaras V. Reklaitis ◽  
Venkat Venkatasubramania
Keyword(s):  
Pharmaceutical Manufacturing ◽  
Roller Compaction ◽  
Modeling And Control ◽  
And Control

Highly sinter-active nanocrystalline RE2O3 (RE = Gd, Eu, Dy) by a combustion process, and role of oxidant-to-fuel ratio in preparing their different crystallographic modifications

2007 ◽  
Vol 22 (3) ◽  
pp. 587-594 ◽  
Author(s):  
V. Bedekar ◽  
S.V. Chavan ◽  
A.K. Tyagi
Keyword(s):  
Combustion Process ◽  
Sintering Behavior ◽  
Stoichiometric Ratio ◽  
Monoclinic Modification ◽  
Fuel Ratio ◽  
Metal Nitrates ◽  
Powder Properties ◽  
Very High ◽  
Scanning Electron

Highly sinter-active powders of RE2O3 [rare earth (RE) = Gd, Eu, Dy] have been prepared using the corresponding metal nitrates as the oxidants, and glycine and citric acid as the fuels. Two different oxidant-to-fuel ratios, namely stoichiometric ratio and fuel-deficient ratio were used to explore the possibility of preparing different crystallographic modifications. By a careful control of oxidant-to-fuel ratio, nanocrystalline Eu2O3 and Gd2O3 could be prepared in cubic (C-type) as well as monoclinic (B-type) modifications. However, the high-temperature monoclinic modification could not be obtained for Dy2O3 due to a very high C-to-B-type phase transition temperature. The crystallite size, surface area, and sintering behavior were also studied for powders prepared using different oxidant-to-fuel ratios, and the results showed a remarkable correlation between different fuel contents and powder properties. Some of these powders resulted in pellets of nearly theoretical density. The sintered microstructure was studied by scanning electron microscopy.

scholarly journals The influence of roller compaction processing variables on the rheological properties of granules

2016 ◽  
Vol 11 (4) ◽  
pp. 516-527 ◽  
Author(s):  
Tim Freeman ◽  
Harmut Vom Bey ◽  
Michael Hanish ◽  
Katrina Brockbank ◽  
Brian Armstrong
Keyword(s):  
Rheological Properties ◽  
Roller Compaction ◽  
Processing Variables
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