The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure

2010 ◽  
Vol 35 (3) ◽  
pp. 403-413 ◽  
Author(s):  
Cristina García-Cáceres ◽  
Yolanda Diz-Chaves ◽  
Natalia Lagunas ◽  
Isabel Calmarza-Font ◽  
Iñigo Azcoitia ◽  
...  
Keyword(s):  
Weight Gain ◽  
Prenatal Stress ◽  
Stress Exposure ◽  
Response To Stress

scholarly journals Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1026
Author(s):  
Kristina Holubova ◽  
Marketa Chvojkova ◽  
Barbora Hrcka Krausova ◽  
Vojtech Vyklicky ◽  
Eva Kudova ◽  
...  
Keyword(s):  
Animal Model ◽  
Nmda Receptor ◽  
Neuroactive Steroids ◽  
Stress Exposure ◽  
Mk 801 ◽  
Receptor Modulator ◽  
Receptor Modulation ◽  
Antipsychotic Effect ◽  
Response To Stress ◽  
Systemic Application

Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic application of MK-801. The neuroactive steroids differ in their mechanism of action at NMDARs. MS-249 is positive, while PA-Glu is a negative allosteric NMDAR modulator. We hypothesized that the positive NMDA receptor modulator would attenuate deficits caused by MK-801 co-application more effectively than PA-Glu. The rats were tested in a battery of tests assessing spontaneous locomotion, anxiety and cognition. Contrary to our expectations, PA-Glu exhibited a superior antipsychotic effect to MS-249. The performance of MS-249-treated rats in cognitive tests differed depending on the level of stress the rats were exposed to during test sessions. In particular, with the increasing severity of stress exposure, the performance of animals worsened. Our results demonstrate that enhancement of NMDAR function may result in unspecific behavioral responses. Positive NMDAR modulation can influence other neurobiological processes besides memory formation, such as anxiety and response to stress.

scholarly journals Prenatal stress exposure is associated with increased dyspnoea perception in adulthood

2017 ◽  
Vol 50 (2) ◽  
pp. 1700642 ◽  
Author(s):  
Andreas von Leupoldt ◽  
Eline Mangelschots ◽  
Nils Georg Niederstrasser ◽  
Marijke Braeken ◽  
Thibo Billiet ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Stress Exposure

scholarly journals Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Livio Provenzi ◽  
Fabiana Mambretti ◽  
Marco Villa ◽  
Serena Grumi ◽  
Andrea Citterio ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Collective Trauma ◽  
Transporter Gene ◽  
Stress Exposure ◽  
Buccal Cells ◽  
Stress Effects ◽  
Cpg Sites ◽  
Stress Related Genes ◽  
Related Stress ◽  
Epigenetic Signatures

AbstractThe COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.

Prenatal stress exposure and early childhood BMI: Exploring associations in a New Zealand context

2018 ◽  
Vol 30 (4) ◽  
pp. e23116 ◽  
Author(s):  
Charlotte V. Farewell ◽  
Zaneta M. Thayer ◽  
David P. Tracer ◽  
Susan Morton
Keyword(s):  
Early Childhood ◽  
New Zealand ◽  
Prenatal Stress ◽  
Stress Exposure

A Nationwide Study on the Risk of Autism After Prenatal Stress Exposure to Maternal Bereavement

PEDIATRICS ◽  
2009 ◽  
Vol 123 (4) ◽  
pp. 1102-1107 ◽  
Author(s):  
J. Li ◽  
M. Vestergaard ◽  
C. Obel ◽  
J. Christensen ◽  
D. H. Precht ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Stress Exposure ◽  
Nationwide Study

scholarly journals Hidden Pandemic: COVID-19-Related Stress, SLC6A4 Methylation and Infants’ Temperament at 3 Months

2021 ◽  
Author(s):  
Livio Provenzi ◽  
Fabiana Mambretti ◽  
Marco Villa ◽  
Serena Grumi ◽  
Andrea Citterio ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Well Being ◽  
Stress Exposure ◽  
Buccal Cells ◽  
Stress Effects ◽  
Cpg Sites ◽  
Preventive Actions ◽  
Stress Related Genes ◽  
Related Stress ◽  
Epigenetic Signatures

Abstract The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months. Clinicians and policymakers should promote timely preventive actions to promote infant well-being during and after the present pandemic.

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