scholarly journals Hidden Pandemic: COVID-19-Related Stress, SLC6A4 Methylation and Infants’ Temperament at 3 Months

Author(s):  
Livio Provenzi ◽  
Fabiana Mambretti ◽  
Marco Villa ◽  
Serena Grumi ◽  
Andrea Citterio ◽  
...  

Abstract The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months. Clinicians and policymakers should promote timely preventive actions to promote infant well-being during and after the present pandemic.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Livio Provenzi ◽  
Fabiana Mambretti ◽  
Marco Villa ◽  
Serena Grumi ◽  
Andrea Citterio ◽  
...  

AbstractThe COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.


Author(s):  
Alexis R. Stefaniak ◽  
Jessica M. Blaxton ◽  
C. S. Bergeman

The present study explores differences in daily stress across individuals of varying ages. Specifically, we explore whether age group (young adult, midlife, late midlife, later life) relates to differences in types of stress (family, friends, partner, health, finances, work), total stress exposure, and perceptions of daily stress intensity. Participants from the Notre Dame Study of Health & Well-being (NDHWB; N = 891) completed daily questionnaires assessing negative small life events and perceived stress for 8 weeks. Findings indicated that young adults reported a higher average number of family, spouse, finance, and work-related stress. Additionally, total daily stress was highest among young adults, and perceived stress was lowest among later life adults. Because daily stress relates to long-term mental and physical stress, gaining a better understanding of how individuals at different points in the life span uniquely experience stress can inform intervention and preventative care techniques aimed at promoting optimal well-being.


Author(s):  
Paul Cullen ◽  
Joan Cahill ◽  
Keith Gaynor

Abstract. Increasing evidence suggests that commercial airline pilots can experience physical, mental, and social health difficulties. Qualitative interviews with commercial airline pilots explored the relationship between work-related stress and well-being. Participatory workshops involving pilots were conducted. The methodology of this action-based research involved a blend of person-centered design approaches; specifically, “stakeholder evaluation” and “participatory design.” The findings further support the hypothesis that pilot well-being is being negatively affected by the nature of their work. The biopsychosocial model of the lived experience of a pilot, as presented in this paper, provides a useful structure to examine pilot well-being, and to identify and scope potential coping strategies to self-manage health and well-being issues associated with the job of being a pilot.


2017 ◽  
Vol 50 (2) ◽  
pp. 1700642 ◽  
Author(s):  
Andreas von Leupoldt ◽  
Eline Mangelschots ◽  
Nils Georg Niederstrasser ◽  
Marijke Braeken ◽  
Thibo Billiet ◽  
...  

2021 ◽  
Author(s):  
Di Romano Benini

The months of a gradual exit from the pandemic show some significant data and phenomena regarding the phenomenon of accidents at work and occupational diseases. The Italian figure highlights a recovery in injuries and illnesses, but also in the impact of new risk factors deriving from the digitalization of work, which grew with smart working during the pandemic. At the same time, the new organizational models highlight the increased risk of work-related stress diseases. The Italian situation makes clear the need to intervene on the issue of organizational well-being and welfare, to limit the negative impact of risk factors associated with this economic system on society and the health system through a new work culture.


2018 ◽  
Vol 30 (4) ◽  
pp. e23116 ◽  
Author(s):  
Charlotte V. Farewell ◽  
Zaneta M. Thayer ◽  
David P. Tracer ◽  
Susan Morton

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